Oxidative stress and cardiovascular disease: new insights

The role of oxidative stress in the onset and progression of atherosclerosis and its impact on the development of cardiovascular events has been widely described. Thus, increased oxidative stress has been described in several atherosclerotic risk factors, such as hypertension, dyslipidaemia, periphe...

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Bibliographic Details
Published in:Kardiologia polska Vol. 76; no. 4; p. 713
Main Authors: Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Violi, Francesco
Format: Journal Article
Language:English
Published: Poland 10.04.2018
Subjects:
Atherosclerosis - metabolism
Humans
Nitric Oxide - metabolism
Oxidative Stress
Reactive Oxygen Species - metabolism
NADPH oxidase
oxidative stress
cardiovascular diseases
ISSN:1897-4279, 1897-4279
Online Access:Get more information
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Summary:The role of oxidative stress in the onset and progression of atherosclerosis and its impact on the development of cardiovascular events has been widely described. Thus, increased oxidative stress has been described in several atherosclerotic risk factors, such as hypertension, dyslipidaemia, peripheral artery disease, metabolic syndrome, diabetes, and obesity. Among others, specific oxidative pathways involving both pro-oxidant and antioxidant enzymes seem to play a major role in the production of reactive oxidant species (ROS), such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase. In this review, we will discuss: 1) the most relevant enzyme systems involved in the formation and detoxification of ROS, 2) the relationship between oxidative stress and cardiovascular risk, and 3) therapeutic implications to modulate oxidative stress.
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ISSN:1897-4279
1897-4279
DOI:10.5603/KP.a2018.0071