Colorectal Cancer Progression Is Potently Reduced by a Glucose-Free, High-Protein Diet: Comparison to Anti-EGFR Therapy

To enable rapid proliferation, colorectal tumor cells up-regulate epidermal growth factor receptor (EGFR) signaling and aerobic glycolysis, resulting in substantial lactate release into the tumor microenvironment and impaired anti-tumor immune responses. We hypothesized that a nutritional interventi...

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Vydáno v:	Cancers Ročník 13; číslo 22; s. 5817
Hlavní autoři:	Skibbe, Kerstin, Brethack, Ann-Kathrin, Sünderhauf, Annika, Ragab, Mohab, Raschdorf, Annika, Hicken, Maren, Schlichting, Heidi, Preira, Joyce, Brandt, Jennifer, Castven, Darko, Föh, Bandik, Pagel, René, Marquardt, Jens U., Sina, Christian, Derer, Stefanie
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Basel MDPI AG 19.11.2021 MDPI
Témata:	Amino acids Antibodies Azoxymethane Carbohydrates Cell culture Cell differentiation Cell division Cell proliferation Colitis Colorectal cancer Colorectal carcinoma Dextran Down-regulation Drinking water Epidermal growth factor Epidermal growth factor receptors Glucose Glucose metabolism Glycolysis High protein diet Immune response Immunotherapy Inflammation Inflammatory bowel disease Kinases Lactic acid Metabolism Monoclonal antibodies Nutrition therapy Oxidative metabolism Oxidative phosphorylation PD-1 protein PD-L1 protein Physical fitness Proteins Rodents Signal transduction Spleen Tumor cells Tumorigenesis Tumors
ISSN:	2072-6694, 2072-6694
On-line přístup:	Získat plný text
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