Colorectal Cancer Progression Is Potently Reduced by a Glucose-Free, High-Protein Diet: Comparison to Anti-EGFR Therapy

To enable rapid proliferation, colorectal tumor cells up-regulate epidermal growth factor receptor (EGFR) signaling and aerobic glycolysis, resulting in substantial lactate release into the tumor microenvironment and impaired anti-tumor immune responses. We hypothesized that a nutritional interventi...

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Bibliographic Details
Published in:	Cancers Vol. 13; no. 22; p. 5817
Main Authors:	Skibbe, Kerstin, Brethack, Ann-Kathrin, Sünderhauf, Annika, Ragab, Mohab, Raschdorf, Annika, Hicken, Maren, Schlichting, Heidi, Preira, Joyce, Brandt, Jennifer, Castven, Darko, Föh, Bandik, Pagel, René, Marquardt, Jens U., Sina, Christian, Derer, Stefanie
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 19.11.2021 MDPI
Subjects:	Amino acids Antibodies Azoxymethane Carbohydrates Cell culture Cell differentiation Cell division Cell proliferation Colitis Colorectal cancer Colorectal carcinoma Dextran Down-regulation Drinking water Epidermal growth factor Epidermal growth factor receptors Glucose Glucose metabolism Glycolysis High protein diet Immune response Immunotherapy Inflammation Inflammatory bowel disease Kinases Lactic acid Metabolism Monoclonal antibodies Nutrition therapy Oxidative metabolism Oxidative phosphorylation PD-1 protein PD-L1 protein Physical fitness Proteins Rodents Signal transduction Spleen Tumor cells Tumorigenesis Tumors
ISSN:	2072-6694, 2072-6694
Online Access:	Get full text
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