Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN‐derived networks and highlights causal links in Alzheimer's disease

Introduction This study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the amyloid/tau/neurodegeneration [AT(N)] framework, mild cognitive impairment (MCI) conversion to Alzheimer's disease (AD), and genetic risk for AD. Methods Us...

Celý popis

Podrobná bibliografia

Vydané v:	Alzheimer's & dementia Ročník 19; číslo 8; s. 3350 - 3364
Hlavní autori:	Shi, Liu, Xu, Jin, Green, Rebecca, Wretlind, Asger, Homann, Jan, Buckley, Noel J., Tijms, Betty M., Vos, Stephanie J. B., Lill, Christina M., Kate, Mara ten, Engelborghs, Sebastiaan, Sleegers, Kristel, Frisoni, Giovanni B., Wallin, Anders, Lleó, Alberto, Popp, Julius, Martinez‐Lage, Pablo, Streffer, Johannes, Barkhof, Frederik, Zetterberg, Henrik, Visser, Pieter Jelle, Lovestone, Simon, Bertram, Lars, Nevado‐Holgado, Alejo J., Proitsi, Petroula, Legido‐Quigley, Cristina
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.08.2023
Predmet:	Alzheimer's disease AT(N) framework Mendelian randomization multimodal biomarker multi‐omics polygenic risk score multi-omics Mendelian randomization AT(N) framework Alzheimer's disease multimodal biomarker polygenic risk score
ISSN:	1552-5260, 1552-5279, 1552-5279
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!