Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN‐derived networks and highlights causal links in Alzheimer's disease

Introduction This study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the amyloid/tau/neurodegeneration [AT(N)] framework, mild cognitive impairment (MCI) conversion to Alzheimer's disease (AD), and genetic risk for AD. Methods Us...

Full description

Bibliographic Details

Published in:	Alzheimer's & dementia Vol. 19; no. 8; pp. 3350 - 3364
Main Authors:	Shi, Liu, Xu, Jin, Green, Rebecca, Wretlind, Asger, Homann, Jan, Buckley, Noel J., Tijms, Betty M., Vos, Stephanie J. B., Lill, Christina M., Kate, Mara ten, Engelborghs, Sebastiaan, Sleegers, Kristel, Frisoni, Giovanni B., Wallin, Anders, Lleó, Alberto, Popp, Julius, Martinez‐Lage, Pablo, Streffer, Johannes, Barkhof, Frederik, Zetterberg, Henrik, Visser, Pieter Jelle, Lovestone, Simon, Bertram, Lars, Nevado‐Holgado, Alejo J., Proitsi, Petroula, Legido‐Quigley, Cristina
Format:	Journal Article
Language:	English
Published:	United States 01.08.2023
Subjects:	Alzheimer's disease AT(N) framework Mendelian randomization multimodal biomarker multi‐omics polygenic risk score multi-omics Mendelian randomization AT(N) framework Alzheimer's disease multimodal biomarker polygenic risk score
ISSN:	1552-5260, 1552-5279, 1552-5279
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!