Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN‐derived networks and highlights causal links in Alzheimer's disease

Introduction This study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the amyloid/tau/neurodegeneration [AT(N)] framework, mild cognitive impairment (MCI) conversion to Alzheimer's disease (AD), and genetic risk for AD. Methods Us...

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Vydáno v:	Alzheimer's & dementia Ročník 19; číslo 8; s. 3350 - 3364
Hlavní autoři:	Shi, Liu, Xu, Jin, Green, Rebecca, Wretlind, Asger, Homann, Jan, Buckley, Noel J., Tijms, Betty M., Vos, Stephanie J. B., Lill, Christina M., Kate, Mara ten, Engelborghs, Sebastiaan, Sleegers, Kristel, Frisoni, Giovanni B., Wallin, Anders, Lleó, Alberto, Popp, Julius, Martinez‐Lage, Pablo, Streffer, Johannes, Barkhof, Frederik, Zetterberg, Henrik, Visser, Pieter Jelle, Lovestone, Simon, Bertram, Lars, Nevado‐Holgado, Alejo J., Proitsi, Petroula, Legido‐Quigley, Cristina
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.08.2023
Témata:	Alzheimer's disease AT(N) framework Mendelian randomization multimodal biomarker multi‐omics polygenic risk score multi-omics Mendelian randomization AT(N) framework Alzheimer's disease multimodal biomarker polygenic risk score
ISSN:	1552-5260, 1552-5279, 1552-5279
On-line přístup:	Získat plný text
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