Regulation of the human HBA genes by KLF4 in erythroid cell lines

Summary KLF1/EKLF and related Krueppel‐like factors (KLFs) are variably implicated in the regulation of the HBB‐like globin genes. Prompted by the observation that four KLF sites are distributed in the human α‐globin gene (HBA) promoter, we investigated if KLFs could also act to modulate the express...

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Vydané v:	British journal of haematology Ročník 149; číslo 5; s. 748 - 758
Hlavní autori:	Marini, M. Giuseppina, Porcu, Loredana, Asunis, Isadora, Loi, M. Giuseppina, Ristaldi, M. Serafina, Porcu, Susanna, Ikuta, Tohru, Cao, Antonio, Moi, Paolo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Oxford, UK Blackwell Publishing Ltd 01.06.2010 Blackwell
Predmet:	Animals Biological and medical sciences Chromatin Immunoprecipitation - methods Down-Regulation - genetics Electrophoretic Mobility Shift Assay - methods Erythroid Cells - metabolism erythroid regulation Gene Expression Regulation Gene Knockdown Techniques - methods GKLF HBA gene expression Hematologic and hematopoietic diseases Hemoglobin A - genetics Humans K562 Cells KLF4 Krueppel‐like factors Kruppel-Like Factor 4 Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Kruppel-Like Transcription Factors - physiology Medical sciences Mice Promoter Regions, Genetic shRNA Transcriptional Activation α‐globin gene Human Erythroid cell Hematology α-globin gene Red blood cell HBA gene expression Gene expression KLF4 erythroid regulation Krppel-like factor 4 Blood cell shRNA Krueppel-like factors Established cell line Alpha globin Alpha-Peptide chain Genetics Short hairpin RNA GKLF
ISSN:	0007-1048, 1365-2141, 1365-2141
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