A novel approach to monitor skin permeation of metals in vitro
How metals permeate skin is poorly understood. Risk assessments tend to take default approaches to account for the dermal route, often using numbers of questionable relevance. Moreover, simultaneous exposure to multiple metals may affect the permeation of individual metals. To investigate this, we d...
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| Vydáno v: | Regulatory toxicology and pharmacology Ročník 115; s. 104693 |
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| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Netherlands
Elsevier Inc
01.08.2020
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| ISSN: | 0273-2300, 1096-0295, 1096-0295 |
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| Abstract | How metals permeate skin is poorly understood. Risk assessments tend to take default approaches to account for the dermal route, often using numbers of questionable relevance. Moreover, simultaneous exposure to multiple metals may affect the permeation of individual metals. To investigate this, we developed an experimental setup where receptor medium circulates directly from a conventional diffusion cell for in vitro skin absorption into an inductively coupled plasma mass spectrometer (ICP-MS), enabling continuous measurement of metal concentration. Full-thickness piglet skin was used as diffusion barrier, artificial sweat as donor medium and phosphate buffered saline as receptor medium. Percutaneous absorption from donor medium containing 2 mmol/L of nickel, cobalt, or chromium or all three combined was monitored for 2 h. Metals retained in skin were quantified post-exposure. Percutaneous absorption of nickel was faster in single than in combined exposure; for cobalt and chromium no such difference was apparent. Similar amounts of the three metals were retained in skin after single exposure, and retention was consistently higher for each metal after combined exposure. This study provides proof-of-concept for a method that reliably detects concentration changes in physiologically relevant medium. It may shed light on skin absorption and permeation kinetics of metals and risks associated with metal exposure.
[Display omitted]
•A method for measuring skin permeation of several metals during ongoing exposure.•Concentration changes in a physiologically relevant receptor medium were detectable.•Permeation rates and skin retention for single and combined exposures are compared. |
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| AbstractList | How metals permeate skin is poorly understood. Risk assessments tend to take default approaches to account for the dermal route, often using numbers of questionable relevance. Moreover, simultaneous exposure to multiple metals may affect the permeation of individual metals. To investigate this, we developed an experimental setup where receptor medium circulates directly from a conventional diffusion cell for in vitro skin absorption into an inductively coupled plasma mass spectrometer (ICP-MS), enabling continuous measurement of metal concentration. Full-thickness piglet skin was used as diffusion barrier, artificial sweat as donor medium and phosphate buffered saline as receptor medium. Percutaneous absorption from donor medium containing 2 mmol/L of nickel, cobalt, or chromium or all three combined was monitored for 2 h. Metals retained in skin were quantified post-exposure. Percutaneous absorption of nickel was faster in single than in combined exposure; for cobalt and chromium no such difference was apparent. Similar amounts of the three metals were retained in skin after single exposure, and retention was consistently higher for each metal after combined exposure. This study provides proof-of-concept for a method that reliably detects concentration changes in physiologically relevant medium. It may shed light on skin absorption and permeation kinetics of metals and risks associated with metal exposure.How metals permeate skin is poorly understood. Risk assessments tend to take default approaches to account for the dermal route, often using numbers of questionable relevance. Moreover, simultaneous exposure to multiple metals may affect the permeation of individual metals. To investigate this, we developed an experimental setup where receptor medium circulates directly from a conventional diffusion cell for in vitro skin absorption into an inductively coupled plasma mass spectrometer (ICP-MS), enabling continuous measurement of metal concentration. Full-thickness piglet skin was used as diffusion barrier, artificial sweat as donor medium and phosphate buffered saline as receptor medium. Percutaneous absorption from donor medium containing 2 mmol/L of nickel, cobalt, or chromium or all three combined was monitored for 2 h. Metals retained in skin were quantified post-exposure. Percutaneous absorption of nickel was faster in single than in combined exposure; for cobalt and chromium no such difference was apparent. Similar amounts of the three metals were retained in skin after single exposure, and retention was consistently higher for each metal after combined exposure. This study provides proof-of-concept for a method that reliably detects concentration changes in physiologically relevant medium. It may shed light on skin absorption and permeation kinetics of metals and risks associated with metal exposure. How metals permeate skin is poorly understood. Risk assessments tend to take default approaches to account for the dermal route, often using numbers of questionable relevance. Moreover, simultaneous exposure to multiple metals may affect the permeation of individual metals. To investigate this, we developed an experimental setup where receptor medium circulates directly from a conventional diffusion cell for in vitro skin absorption into an inductively coupled plasma mass spectrometer (ICP-MS), enabling continuous measurement of metal concentration. Full-thickness piglet skin was used as diffusion barrier, artificial sweat as donor medium and phosphate buffered saline as receptor medium. Percutaneous absorption from donor medium containing 2 mmol/L of nickel, cobalt, or chromium or all three combined was monitored for 2 h. Metals retained in skin were quantified post-exposure. Percutaneous absorption of nickel was faster in single than in combined exposure; for cobalt and chromium no such difference was apparent. Similar amounts of the three metals were retained in skin after single exposure, and retention was consistently higher for each metal after combined exposure. This study provides proof-of-concept for a method that reliably detects concentration changes in physiologically relevant medium. It may shed light on skin absorption and permeation kinetics of metals and risks associated with metal exposure. [Display omitted] •A method for measuring skin permeation of several metals during ongoing exposure.•Concentration changes in a physiologically relevant receptor medium were detectable.•Permeation rates and skin retention for single and combined exposures are compared. How metals permeate skin is poorly understood. Risk assessments tend to take default approaches to account for the dermal route, often using numbers of questionable relevance. Moreover, simultaneous exposure to multiple metals may affect the permeation of individual metals. To investigate this, we developed an experimental setup where receptor medium circulates directly from a conventional diffusion cell for in vitro skin absorption into an inductively coupled plasma mass spectrometer (ICP-MS), enabling continuous measurement of metal concentration. Full-thickness piglet skin was used as diffusion barrier, artificial sweat as donor medium and phosphate buffered saline as receptor medium. Percutaneous absorption from donor medium containing 2 mmol/L of nickel, cobalt, or chromium or all three combined was monitored for 2 h. Metals retained in skin were quantified post-exposure. Percutaneous absorption of nickel was faster in single than in combined exposure; for cobalt and chromium no such difference was apparent. Similar amounts of the three metals were retained in skin after single exposure, and retention was consistently higher for each metal after combined exposure. This study provides proof-of-concept for a method that reliably detects concentration changes in physiologically relevant medium. It may shed light on skin absorption and permeation kinetics of metals and risks associated with metal exposure. |
| ArticleNumber | 104693 |
| Author | Julander, Anneli Schenk, Linda Midander, Klara |
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| CitedBy_id | crossref_primary_10_1016_j_tiv_2020_105062 crossref_primary_10_1186_s12995_024_00442_5 crossref_primary_10_1016_j_envpol_2021_118353 crossref_primary_10_1016_j_tiv_2021_105232 crossref_primary_10_1016_j_yrtph_2020_104752 crossref_primary_10_1080_10408444_2022_2097052 crossref_primary_10_1016_j_ijbiomac_2024_134168 crossref_primary_10_1111_cod_14137 |
| Cites_doi | 10.1016/S0378-5173(00)00665-7 10.1016/j.chemosphere.2015.11.076 10.1016/j.tiv.2012.09.007 10.1136/oemed-2018-105099 10.1111/j.1600-0536.1990.tb01553.x 10.1111/bjd.16935 10.1016/j.tiv.2008.10.008 10.1111/srt.12098 10.1021/acs.chemrestox.5b00421 10.1159/000076805 10.1080/000155501753279596 10.1016/j.tiv.2018.04.009 10.1371/journal.pone.0205458 10.1016/0048-9697(94)90141-4 10.1208/pt0804094 10.1111/cod.12790 10.1111/cod.12426 10.1016/j.ijheh.2018.05.016 10.1111/j.1600-0536.2008.01326.x 10.1080/15428110208984751 10.3390/ijerph120708263 10.1111/cod.12092 10.1016/j.toxlet.2007.02.009 10.1111/j.1600-0536.1986.tb01320.x 10.1111/cod.13136 |
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| Keywords | Skin penetration Sensitizing metals Risk assessment Chromium Mixed exposure Mixtures of metals Dermal exposure Nickel ICP-MS Cobalt Diffusion cell |
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| SubjectTerms | Animals Chromium Cobalt Dermal exposure Diffusion Diffusion cell ICP-MS In Vitro Techniques Metals, Heavy - analysis Metals, Heavy - metabolism Mixed exposure Mixtures of metals Nickel Risk assessment Sensitizing metals Skin - chemistry Skin - metabolism Skin Absorption Skin penetration Swine |
| Title | A novel approach to monitor skin permeation of metals in vitro |
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