Gene Polymorphisms and the Prevalence of Key Periodontal Pathogens

Growing evidence suggests that individual genetic susceptibility may influence the host’s response to infections. The aim of this project was to study whether gene polymorphisms of inflammatory markers are associated with the presence of viable periodontopathogenic bacteria. We extracted genomic DNA...

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Bibliographic Details
Published in:Journal of dental research Vol. 86; no. 5; pp. 416 - 420
Main Authors: Nibali, L., Ready, D.R., Parkar, M., Brett, P.M., Wilson, M., Tonetti, M.S., Griffiths, G.S.
Format: Journal Article
Language:English
Published: United States SAGE Publications 01.05.2007
SAGE PUBLICATIONS, INC
Subjects:
Adult
Aggregatibacter actinomycetemcomitans - isolation & purification
aggressive periodontitis
Analysis of Variance
Antigens, CD - genetics
bacteria
Bacteroides - isolation & purification
Fcγ receptors
Female
genetic polymorphisms
Genetic Predisposition to Disease
Humans
Inflammation Mediators
interleukin-6
Interleukin-6 - genetics
Logistic Models
Male
Periodontitis - genetics
Periodontitis - immunology
Periodontitis - microbiology
Polymorphism, Genetic
Porphyromonas gingivalis - isolation & purification
Receptors, Calcitriol - genetics
Receptors, Fc - genetics
Receptors, Formyl Peptide - genetics
Receptors, IgG - genetics
Tumor Necrosis Factor-alpha - genetics
aggressive periodontitis
bacteria
Fcγ receptors
genetic polymorphisms
interleukin-6
ISSN:0022-0345, 1544-0591
Online Access:Get full text
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Summary:Growing evidence suggests that individual genetic susceptibility may influence the host’s response to infections. The aim of this project was to study whether gene polymorphisms of inflammatory markers are associated with the presence of viable periodontopathogenic bacteria. We extracted genomic DNA from 45 young adults diagnosed with generalized aggressive periodontitis to study Fc receptors, formyl peptide receptor, Interleukin-6, tumor necrosis factor-α, and vitamin D receptor polymorphisms. The presence and viable numbers of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis were determined by culture, and their identities confirmed by PCR. Multiple logistic regressions revealed that both Fcγ receptor and IL-6 -174 polymorphisms were associated with increased odds of detecting A. actinomycetemcomitans, P. gingivalis, and T. forsythensis after adjustment for age, ethnicity, smoking, and periodontitis extent. These findings support the hypothesis that complex interactions between the microbiota and host genome may be at the basis of susceptibility to aggressive periodontitis.
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ISSN:0022-0345
1544-0591
DOI:10.1177/154405910708600505