Ferroptosis in Intrahepatic Cholangiocarcinoma: IDH1105GGT Single Nucleotide Polymorphism Is Associated With Its Activation and Better Prognosis

ObjectivesIntrahepatic cholangiocarcinoma (ICC) has a dismal prognosis and often demonstrates an anti-apoptotic landscape, which is a key step to chemotherapy resistance. Isocitrate dehydrogenase 1 or 2 ( IDH1-2 )-mutated ICCs have been described and associated with better prognosis. Ferroptosis is...

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Veröffentlicht in:	Frontiers in medicine Jg. 9; S. 886229
Hauptverfasser:	Sarcognato, Samantha, Sacchi, Diana, Fabris, Luca, Zanus, Giacomo, Gringeri, Enrico, Niero, Monia, Gallina, Giovanna, Guido, Maria
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Lausanne Frontiers Media SA 08.07.2022 Frontiers Media S.A
Schlagworte:	Apoptosis Biopsy Cancer therapies Chemotherapy Cholangiocarcinoma Cloning Ferroptosis Glutathione GPX4 IDH1105GGT single nucleotide polymorphism intrahepatic cholangiocarcinoma Liver Medical prognosis Medicine Mutation Software Stains & staining STAT3 Surgery Surgical outcomes Denmark United States > US Italy
ISSN:	2296-858X, 2296-858X
Online-Zugang:	Volltext
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