A wearable hemofilter for continuous ambulatory ultrafiltration

Ultrafiltration is effective for treating fluid overload, but there are no suitable machines for ambulatory treatment. This study summarizes the use of a light-weight wearable continuous ambulatory ultrafiltration device consisting of a hollow fiber hemofilter, a battery operated pulsatile pump, and...

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Vydáno v:Kidney international Ročník 73; číslo 4; s. 497 - 502
Hlavní autoři: Gura, V., Ronco, C., Nalesso, F., Brendolan, A., Beizai, M., Ezon, C., Davenport, A., Rambod, E.
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York, NY Elsevier Inc 01.02.2008
Nature Publishing
Elsevier Limited
Témata:
Adult
Aged
Aged, 80 and over
Ambulatory Care
Biological and medical sciences
Cardiology. Vascular system
congestive cardiac failure
CRRT
Female
fluid overload
Heart
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hemofiltration - instrumentation
Humans
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Renal Replacement Therapy - instrumentation
ultrafiltration
Ultrafiltration - instrumentation
wearable hemofiltration device
wearable hemofiltration device
congestive cardiac failure
fluid overload
ultrafiltration
CRRT
Heart failure
Nephrology
Continuous
Device
Fluid
Cardiovascular disease
Urology
Extrarenal dialysis
Ultrafiltration
Overload
Heart disease
Hemofiltration
Ambulatory
ISSN:0085-2538, 1523-1755, 1523-1755
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Shrnutí:Ultrafiltration is effective for treating fluid overload, but there are no suitable machines for ambulatory treatment. This study summarizes the use of a light-weight wearable continuous ambulatory ultrafiltration device consisting of a hollow fiber hemofilter, a battery operated pulsatile pump, and two micropumps to control heparin administration and ultrafiltration. Six volume-overloaded patients underwent ultrafiltration for 6 h with treatment discontinued in one patient due to a clotted catheter. Blood flow averaged 116 ml min−1, the ultrafiltration rate ranged from 120–288 ml h−1 with about 150 mmol of sodium removed. Blood pressure, pulse, and biochemical parameters remained stable with no significant hemolysis or complications. Our data show that the wearable hemofilter appears to be safe, effective, and practical for patients. This device could have a major impact on the quality of life of fluid-overloaded patients with heart failure. Additional studies will be needed to confirm these initial promising results.
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ISSN:0085-2538
1523-1755
1523-1755
DOI:10.1038/sj.ki.5002711