The emerging importance of lymphangiogenesis in aging and aging-associated diseases

Lymphatic aging represented by cellular and functional changes, is involved in increased geriatric disorders, but the intersection between aging and lymphatic modulation is less clear. Lymphatic vessels play an essential role in maintaining tissue fluid homeostasis, regulating immune function, and p...

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Vydáno v:Mechanisms of ageing and development Ročník 221; s. 111975
Hlavní autor: Ji, Rui-Cheng
Médium: Journal Article
Jazyk:angličtina
Vydáno: Ireland Elsevier B.V 01.10.2024
Témata:
Aging
Lymphangiogenesis
Lymphatic-associated diseases
Macrophage
Senescence-associated secretory phenotype (SASP)
VEGF-C/VEGFR-3
Aging
Senescence-associated secretory phenotype (SASP)
Lymphatic-associated diseases
Lymphangiogenesis
VEGF-C/VEGFR-3
Macrophage
ISSN:0047-6374, 1872-6216, 1872-6216
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Abstract Lymphatic aging represented by cellular and functional changes, is involved in increased geriatric disorders, but the intersection between aging and lymphatic modulation is less clear. Lymphatic vessels play an essential role in maintaining tissue fluid homeostasis, regulating immune function, and promoting macromolecular transport. Lymphangiogenesis and lymphatic remodeling following cellular senescence and organ deterioration are crosslinked with the progression of some lymphatic-associated diseases, e.g., atherosclerosis, inflammation, lymphoedema, and cancer. Age-related detrimental tissue changes may occur in lymphatic vessels with diverse etiologies, and gradually shift towards chronic low-grade inflammation, so-called inflammaging, and lead to decreased immune response. The investigation of the relationship between advanced age and organ deterioration is becoming an area of rapidly increasing significance in lymphatic biology and medicine. Here we highlight the emerging importance of lymphangiogenesis and lymphatic remodeling in the regulation of aging-related pathological processes, which will help to find new avenues for effective intervention to promote healthy aging. •Lymphatic aging represented by cellular and functional changes is an increased risk factor for geriatric disorders.•Advanced age and organ deterioration are crosslinked with the progression of some lymphatic-associated diseases.•Lymphangiogenesis and lymphatic remodeling are involved in the regulation of aging-related pathological processes.•Targeting aging-induced lymphatic dysfunction will help to reduce the burden of age-related diseases.
AbstractList Lymphatic aging represented by cellular and functional changes, is involved in increased geriatric disorders, but the intersection between aging and lymphatic modulation is less clear. Lymphatic vessels play an essential role in maintaining tissue fluid homeostasis, regulating immune function, and promoting macromolecular transport. Lymphangiogenesis and lymphatic remodeling following cellular senescence and organ deterioration are crosslinked with the progression of some lymphatic-associated diseases, e.g., atherosclerosis, inflammation, lymphoedema, and cancer. Age-related detrimental tissue changes may occur in lymphatic vessels with diverse etiologies, and gradually shift towards chronic low-grade inflammation, so-called inflammaging, and lead to decreased immune response. The investigation of the relationship between advanced age and organ deterioration is becoming an area of rapidly increasing significance in lymphatic biology and medicine. Here we highlight the emerging importance of lymphangiogenesis and lymphatic remodeling in the regulation of aging-related pathological processes, which will help to find new avenues for effective intervention to promote healthy aging.
Lymphatic aging represented by cellular and functional changes, is involved in increased geriatric disorders, but the intersection between aging and lymphatic modulation is less clear. Lymphatic vessels play an essential role in maintaining tissue fluid homeostasis, regulating immune function, and promoting macromolecular transport. Lymphangiogenesis and lymphatic remodeling following cellular senescence and organ deterioration are crosslinked with the progression of some lymphatic-associated diseases, e.g., atherosclerosis, inflammation, lymphoedema, and cancer. Age-related detrimental tissue changes may occur in lymphatic vessels with diverse etiologies, and gradually shift towards chronic low-grade inflammation, so-called inflammaging, and lead to decreased immune response. The investigation of the relationship between advanced age and organ deterioration is becoming an area of rapidly increasing significance in lymphatic biology and medicine. Here we highlight the emerging importance of lymphangiogenesis and lymphatic remodeling in the regulation of aging-related pathological processes, which will help to find new avenues for effective intervention to promote healthy aging. •Lymphatic aging represented by cellular and functional changes is an increased risk factor for geriatric disorders.•Advanced age and organ deterioration are crosslinked with the progression of some lymphatic-associated diseases.•Lymphangiogenesis and lymphatic remodeling are involved in the regulation of aging-related pathological processes.•Targeting aging-induced lymphatic dysfunction will help to reduce the burden of age-related diseases.
Lymphatic aging represented by cellular and functional changes, is involved in increased geriatric disorders, but the intersection between aging and lymphatic modulation is less clear. Lymphatic vessels play an essential role in maintaining tissue fluid homeostasis, regulating immune function, and promoting macromolecular transport. Lymphangiogenesis and lymphatic remodeling following cellular senescence and organ deterioration are crosslinked with the progression of some lymphatic-associated diseases, e.g., atherosclerosis, inflammation, lymphoedema, and cancer. Age-related detrimental tissue changes may occur in lymphatic vessels with diverse etiologies, and gradually shift towards chronic low-grade inflammation, so-called inflammaging, and lead to decreased immune response. The investigation of the relationship between advanced age and organ deterioration is becoming an area of rapidly increasing significance in lymphatic biology and medicine. Here we highlight the emerging importance of lymphangiogenesis and lymphatic remodeling in the regulation of aging-related pathological processes, which will help to find new avenues for effective intervention to promote healthy aging.Lymphatic aging represented by cellular and functional changes, is involved in increased geriatric disorders, but the intersection between aging and lymphatic modulation is less clear. Lymphatic vessels play an essential role in maintaining tissue fluid homeostasis, regulating immune function, and promoting macromolecular transport. Lymphangiogenesis and lymphatic remodeling following cellular senescence and organ deterioration are crosslinked with the progression of some lymphatic-associated diseases, e.g., atherosclerosis, inflammation, lymphoedema, and cancer. Age-related detrimental tissue changes may occur in lymphatic vessels with diverse etiologies, and gradually shift towards chronic low-grade inflammation, so-called inflammaging, and lead to decreased immune response. The investigation of the relationship between advanced age and organ deterioration is becoming an area of rapidly increasing significance in lymphatic biology and medicine. Here we highlight the emerging importance of lymphangiogenesis and lymphatic remodeling in the regulation of aging-related pathological processes, which will help to find new avenues for effective intervention to promote healthy aging.
ArticleNumber 111975
Author Ji, Rui-Cheng
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  givenname: Rui-Cheng
  surname: Ji
  fullname: Ji, Rui-Cheng
  email: JI@oita-u.ac.jp
  organization: Faculty of Welfare and Health Science, Oita University, Oita 870-1192, Japan
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Cites_doi 10.1038/84651
10.1016/j.celrep.2016.09.083
10.1182/blood-2007-11-125203
10.1016/j.phymed.2023.154684
10.1002/eji.201546178
10.1111/j.0105-2896.2005.00260.x
10.1007/s10456-020-09718-w
10.1172/JCI64096
10.1016/j.jshs.2022.02.005
10.18632/aging.101113
10.1111/acel.12062
10.1007/s11033-023-08620-0
10.1146/annurev-physiol-020518-114310
10.2353/ajpath.2007.060018
10.1084/jem.20201776
10.1038/75997
10.1016/j.bbadis.2023.166815
10.1126/scitranslmed.3003748
10.1038/labinvest.2011.84
10.1002/art.42441
10.1038/s41574-018-0059-4
10.1111/acel.13136
10.1016/j.intimp.2020.106294
10.1007/s11064-015-1581-6
10.1016/j.celrep.2024.114020
10.1371/journal.pone.0091850
10.1016/j.atherosclerosis.2010.05.026
10.4049/jimmunol.1102188
10.1152/ajpheart.00538.2011
10.1111/j.1365-2362.2010.02431.x
10.1038/nature14432
10.1159/000504480
10.1126/scitranslmed.aal4712
10.1016/j.cell.2022.12.031
10.1016/j.atherosclerosis.2019.01.031
10.1016/j.ejmech.2021.113664
10.1152/ajpheart.00378.2012
10.1038/nrm3823
10.1111/j.1549-8719.2011.00107.x
10.1111/acel.12865
10.1371/journal.ppat.1005027
10.1002/ana.25670
10.1002/cphy.c180015
10.1038/s41598-020-67987-3
10.1152/ajpendo.00422.2018
10.1089/lrb.2011.0022
10.18632/aging.203567
10.1016/j.jid.2015.12.001
10.1172/JCI23874
10.1172/jci.insight.84095
10.1038/cr.2013.168
10.1038/nrc3773
10.1016/j.jid.2020.11.006
10.1038/s41586-023-06899-4
10.1152/ajpheart.00598.2014
10.1016/j.immuni.2017.05.008
10.1016/j.arr.2008.07.002
10.1016/j.trsl.2023.01.005
10.3390/cells11010160
10.1007/s10741-021-10188-5
10.1016/j.it.2009.05.004
10.1007/s00109-022-02193-4
10.3390/nu15132873
10.1161/CIRCRESAHA.109.197830
10.1152/physrev.00061.2017
10.1007/s10522-015-9578-8
10.7150/ijbs.66781
10.1016/j.molmed.2021.07.003
10.1016/j.ebiom.2019.10.034
10.1146/annurev-pathol-121808-102144
10.1038/s41392-023-01451-2
10.1590/0001-3765201720160487
10.1038/s41586-018-0368-8
10.1016/j.tcb.2015.10.005
10.1016/j.cmet.2022.11.001
10.1096/fasebj.10.9.8801171
10.1126/science.aax4063
10.1038/jid.2008.351
10.1126/science.273.5271.70
10.1152/physrev.00020.2018
10.1021/bi2011866
10.1038/nrneurol.2015.119
10.1007/s00018-011-0848-6
10.1038/s41580-018-0033-y
10.1038/s43587-021-00098-4
10.1038/s41467-023-36562-5
10.1002/jcsm.12166
10.1002/mus.27402
10.1016/j.cell.2008.03.039
10.1126/science.abc8059
10.1172/JCI140685
10.1172/JCI95148
10.1007/s10585-018-9940-8
10.1007/s00109-010-0667-5
10.1155/2014/615312
10.1093/ageing/afy169
10.1126/science.abg7292
10.1073/pnas.92.10.4337
10.1128/JVI.00801-17
10.1096/fj.99-1049com
10.1186/s12987-023-00412-9
10.1084/jem.20142290
10.1152/ajpheart.00133.2011
10.1084/jem.20211830
10.1177/0271678X18822921
10.18632/aging.203405
10.2353/ajpath.2010.100594
10.1161/ATVBAHA.114.302528
10.1080/15548627.2017.1380757
10.1084/jem.20170391
10.1016/j.cell.2013.05.039
10.1002/art.40047
10.1172/JCI15830
10.1007/s11033-014-3073-1
10.1007/s10456-015-9479-0
10.3389/fragi.2022.864860
10.1016/j.exer.2008.07.013
10.3390/ijms18050965
10.1016/j.arr.2021.101468
10.1002/art.24764
10.1158/0008-5472.CAN-04-0088
10.1172/JCI26354
10.3389/fmolb.2022.991612
10.1084/jem.20221929
10.1016/j.jamda.2013.05.009
10.1073/pnas.2121028119
10.1113/JP272088
10.1161/CIRCULATIONAHA.110.965384
10.3727/105221620X15960509906371
10.1371/journal.pone.0232356
10.3390/biology10040293
10.1038/s41467-021-27887-0
10.1016/j.lfs.2018.09.043
10.1089/jir.2011.0058
10.1016/S0531-5565(01)00205-4
10.1016/j.biopha.2023.116032
10.1172/JCI63685
10.1038/s41467-017-01484-6
10.15252/emmm.201505731
10.3389/fonc.2023.1140891
10.1161/CIRCRESAHA.121.318307
10.1002/(SICI)1097-0029(19970601)37:5/6<456::AID-JEMT9>3.0.CO;2-B
10.1016/j.molmed.2021.12.003
10.1161/CIRCULATIONAHA.123.064181
10.3389/fcell.2021.645593
10.1038/gt.2011.66
10.1161/CIRCRESAHA.123.322136
10.1038/s41577-020-0281-x
10.1126/sciadv.abe4601
10.1038/s41586-019-1912-x
10.1038/s41422-020-0287-8
10.1016/j.bbi.2022.04.005
10.3390/cells10113148
10.15252/embr.201846927
10.1111/febs.13545
10.1096/fj.02-1049fje
10.3389/fimmu.2022.943159
10.18632/aging.102213
10.1038/s43587-023-00442-w
10.3389/fimmu.2019.00470
10.1038/s43587-022-00268-y
10.1046/j.1532-5415.2002.50216.x
10.1172/JCI60113
10.3390/cells10051054
10.1089/ars.2013.5371
10.1038/s41580-019-0101-y
10.1159/000508459
10.1002/jemt.20082
10.1038/s41419-020-03385-x
10.3389/fcvm.2021.763930
10.1167/iovs.62.13.17
10.1038/nri978
10.1159/000490349
10.1038/s41467-018-08163-0
10.3389/fimmu.2020.01234
10.4103/1673-5374.230299
10.1111/acel.12330
10.1182/blood-2007-10-120337
10.1016/j.mucimm.2024.05.003
10.1172/JCI72189
10.1038/s41586-019-1419-5
10.1038/s41586-023-06373-1
10.1016/j.stem.2022.04.017
10.2174/1871528113666140522112003
10.1089/lrb.2012.0025
10.3390/cells11071249
10.1016/j.exger.2020.111200
10.1152/japplphysiol.00495.2019
10.3390/jcm10215129
10.1161/01.RES.0000073584.46059.E3
10.1016/j.jid.2020.11.010
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Keywords Aging
Senescence-associated secretory phenotype (SASP)
Lymphatic-associated diseases
Lymphangiogenesis
VEGF-C/VEGFR-3
Macrophage
Language English
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References Yoon, Jin, Kim, Hong, Yang, Ahn, Kim, Seo, Lee, McDonald, Davis, Koh (bib187) 2024; 625
Yoshimatsu, Kimuro, Pauty, Takagaki, Nomiyama, Inagawa, Maeda, Podyma-Inoue, Kajiya, Matsunaga, Watabe (bib190) 2020; 15
Delval, Hantute-Ghesquier, Sencio, Flaman, Robil, Angulo, Lipskaia, Çobanoğlu, Lacoste, Machelart, Danneels, Corbin, Deruyter, Heumel, Idziorek, Séron, Sauve, Bongiovanni, Prévot, Wolowczuk, Belouzard, Saliou, Gosset, Bernard, Rouillé, Adnot, Duterque-Coquillaud, Trottein (bib38) 2023; 3
Dube, Ong, Wemyss, Krishnan, Tan, Janela, Grainger, Ronshaugen, Mace, Lim (bib40) 2022; 13
Franceschi, Garagnani, Parini, Giuliani, Santoro (bib46) 2018; 14
He, Rajantie, Ilmonen, Makinen, Karkkainen, Haiko, Salven, Alitalo (bib62) 2004; 64
Houbaert, Nikolakopoulos, Jacobs, Meçe, Roles, Shankar, Agrawal, More, Ganne, Rillaerts, Boon, Swoboda, Nobis, Mourao, Bosisio, Vandamme, Bergers, Scheele, Agostinis (bib69) 2024; 43
Yoon, Hong, Moon, Lim, Suh, Kim, Chae, Gho (bib186) 2008; 112
Suh, Choe, Hong, Jeong, Mäkinen, Kim, Alitalo, Surh, Koh, Song (bib167) 2019; 20
Hansen, Rubinsztein, Walker (bib59) 2018; 19
Ma, Wang, Ye, Ren, Chen, Li, Li, Zhao, Zhao, Sun, Jing, Zuo, Xiong, Yang, Wang, Lei, Sun, Long, Song, Yu, Chan, Wang, Zhou, Belmonte, Qu, Zhang, Liu (bib113) 2022; 29
Gardenier, Hespe, Kataru, Savetsky, Torrisi, Nores, Dayan, Chang, Zampell, Martínez-Corral, Ortega, Mehrara (bib50) 2016; 1
Herrero, Sebastián, Marqués, Comalada, Xaus, Valledor, Lloberas, Celada (bib65) 2002; 37
Sonar, Uhrlaub, Coplen, Sempowski, Dudakov, van den Brink, LaFleur, Jergović, Nikolich-Žugich (bib162) 2022; 119
Karaman, Buschle, Luciani, Leroux, Detmar, Proulx (bib87) 2015; 18
Guo, Zhou, Proulx, Wood, Ji, Ritchlin, Pytowski, Zhu, Wang, Schwarz, Xing (bib57) 2009; 60
Yang, Kalantari, Ruan, Sun, Bian, Guan (bib184) 2023; 14
O'Morchoe (bib138) 1997; 37
Rustenhoven, Pavlou, Storck, Dykstra, Du, Wan, Quintero, Scallan, Smirnov, Kamm, Kipnis (bib156) 2023; 220
Stout, Suttles (bib165) 2005; 205
Reidy, McKenzie, Mahmassani, Petrocelli, Nelson, Lindsay, Gardner, Morrow, Keefe, Huffaker, Stoddard, Kardon, O'Connell, Drummond (bib152) 2019; 317
Bei, Huang, Feng, Li, Wei, Zhu, Liu, Chen, Yin, Jiang, Xiao (bib12) 2022; 11
Zhang, Zhang, Li, Liang, Cheng, Li, Chang, Wang, Huang, Li, Liu, Xu (bib193) 2021; 12
Chung, Cesari, Anton, Marzetti, Giovannini, Seo, Carter, Yu, Leeuwenburgh (bib29) 2009; 8
Pal, Nath, Meininger, Gashev (bib142) 2020; 11
Ogata, Fujiu, Matsumoto, Nakayama, Shibata, Oike, Koshima, Watabe, Nagai, Manabe (bib136) 2016; 136
Herranz, Gil (bib64) 2018; 128
Tarasoff-Conway, Carare, Osorio, Glodzik, Butler, Fieremans, Axel, Rusinek, Nicholson, Zlokovic, Frangione, Blennow, Ménard, Zetterberg, Wisniewski, de Leon (bib168) 2015; 11
Biswas, Chen, De Angelis, Singh, Owen-Woods, Ding, Pujol, Kumar, Zeng, Ramasamy, Kusumbe (bib16) 2023; 186
Rockson (bib155) 2021; 128
Stritt, Koltowska, Mäkinen (bib166) 2021; 27
Bilski, Pierzchalski, Szczepanik, Bonior, Zoladz (bib15) 2022; 11
Hassan, van Klaveren, Håkansson, Diehl, Kovačič, Baussière, Sundin, Dernovšek, Walse, Zetterberg, Leffler, Anderluh, Tomašič, Jakopin, Nilsson (bib61) 2021; 223
Karvinen, Pasanen, Rissanen, Korpisalo, Vähäkangas, Jazwa, Giacca, Ylä-Herttuala (bib89) 2011; 18
Milasan, Smaani, Martel (bib122) 2019; 283
Ochi, Kohara, Tabara, Kido, Uetani, Ochi, Igase, Miki (bib134) 2010; 212
Rissanen, Markkanen, Gruchala, Heikura, Puranen, Kettunen, Kholová, Kauppinen, Achen, Stacker, Alitalo, Ylä-Herttuala (bib154) 2003; 92
Triolo, Hood (bib173) 2021; 10
Wen, Yang, Wang, Yao (bib179) 2018; 13
Kataru, Park, Shin, Baik, Sarker, Brown, Mehrara (bib92) 2022; 3
Zhuang, Lyga (bib196) 2014; 13
Churchill, du Bois, Heim, Mudianto, Steele, Nolz, Lund (bib30) 2022; 219
Wada, Nakao, Yamaguchi, Kaizu, Arima, Sawa, Sonoda (bib176) 2021; 62
Bridenbaugh, Nizamutdinova, Jupiter, Nagai, Thangaswamy, Chatterjee, Gashev (bib19) 2013; 11
Aspelund, Antila, Proulx, Karlsen, Karaman, Detmar, Wiig, Alitalo (bib9) 2015; 212
Jakic, Kerjaschki, Wick (bib76) 2020; 66
Mäkinen, Jussila, Veikkola, Karpanen, Kettunen, Pulkkanen, Kauppinen, Jackson, Kubo, Nishikawa, Ylä-Herttuala, Alitalo (bib116) 2001; 7
Budamagunta, Foster, Zhou (bib21) 2021; 13
Scallan, Zawieja, Castorena-Gonzalez, Davis (bib158) 2016; 594
Cao, Jin, Liu (bib24) 2020; 19
Larsson, Degens, Li, Salviati, Lee, Thompson, Kirkland, Sandri (bib103) 2019; 99
Maruyama, Ii, Cursiefen, Jackson, Keino, Tomita, Van Rooijen, Takenaka, D'Amore, Stein-Streilein, Losordo, Streilein (bib118) 2005; 115
Yoon, Murayama, Gravereaux, Tkebuchava, Silver, Curry, Wecker, Kirchmair, Hu, Kearney, Ashare, Jackson, Kubo, Isner, Losordo (bib188) 2003; 111
Zolla, Nizamutdinova, Scharf, Clement, Maejima, Akl, Nagai, Luciani, Leroux, Halin, Stukes, Tiwari, Casadevall, Jacobs, Entenberg, Zawieja, Condeelis, Fooksman, Gashev, Santambrogio (bib197) 2015; 14
Liu, Liang, Ren, Guo, Ge, Wang, Cheng, Luo, Zhang, Han (bib107) 2023; 8
Yoshida, Koshima, Imai, Roh, Mese, Uchiki, Sasaki, Nagamatsu (bib189) 2021; 10
Aman, Schmauck-Medina, Hansen, Morimoto, Simon, Bjedov, Palikaras, Simonsen, Johansen, Tavernarakis, Rubinsztein, Partridge, Kroemer, Labbadia, Fang (bib5) 2021; 1
Kumari, Jat (bib100) 2021; 9
Harlé, Kowalski, Dubrot, Brighouse, Clavel, Pick, Bessis, Niven, Scheiermann, Gannagé, Hugues (bib60) 2021; 218
Richner, Gmyrek, Govero, Tu, van der Windt, Metcalf, Haddad, Textor, Miller, Diamond (bib153) 2015; 11
Wei, Chen, Li, Liang, Wang, Zhang, Li, Liu, Xu (bib178) 2022; 18
Chen, Fischer, Reagan, Yan, Ames (bib26) 1995; 92
Nelke, Dziewas, Minnerup, Meuth, Ruck (bib129) 2019; 49
Ji (bib82) 2022; 27
Glinton, Ma, Lantz, Grigoryeva, DeBerge, Liu, Febbraio, Kahn, Oliver, Thorp (bib52) 2022; 132
Ahn, Cho, Kim, Kim, Ham, Park, Suh, Hong, Song, Hong, Jeong, Park, Koh (bib1) 2019; 572
Thompson, Smithey, Uhrlaub, Jeftić, Jergović, White, Currier, Lang, Okoye, Park, Picker, Surh, Nikolich-Žugich (bib170) 2019; 18
Salminen (bib157) 2022; 100
Kundu, Kennedy, Meadows, Baiocchi, Alpini, Francis (bib101) 2020; 20
Zhu, Li, Liu, Li (bib195) 2023; 13
Ma, Ineichen, Detmar, Proulx (bib112) 2017; 8
Kataru, Baik, Park, Wiser, Rehal, Shin, Mehrara (bib91) 2019; 10
Janssen, Heymsfield, Ross (bib78) 2002; 50
López-Otín, Pietrocola, Roiz-Valle, Galluzzi, Kroemer (bib109) 2023; 35
Brown, Nores, Sarker, Ly, Li, Park, Hespe, Gardenier, Kuonqui, Campbell, Shin, Kataru, Aras, Mehrara (bib20) 2023; 257
You, Liang (bib191) 2023; 1869
Cakala-Jakimowicz, Kolodziej-Wojnar, Puzianowska-Kuznicka (bib22) 2021; 10
Kim, Tian, Wu, Xiang, Vinh, Chang, Gu, Lee, Zhu, Guan, Schneider, Bao, Dixon, Kao, Pan, Rockson, Jiang, Nicolls (bib98) 2023; 148
Jessen, Munk, Lundgaard, Nedergaard (bib79) 2015; 40
Kawashima, Ji, Itoh, Agata, Sasai, Murakami, Sokabe, Hamada, Kawakami (bib94) 2021; 64
Gordon (bib55) 2003; 3
Yang, Wang, Wang (bib185) 2023
Ungvari, Sonntag, Csiszar (bib174) 2010; 88
Chatterjee, Gashev (bib25) 2012; 303
Lumeng, Liu, Geletka, Delaney, Delproposto, Desai, Oatmen, Martinez-Santibanez, Julius, Garg, Yung (bib111) 2011; 187
Mazzuca, Marsico, Schulze, Mitola, Pils, Giagulli, Guzman, Caruso, Caccuri (bib120) 2017; 91
Paavonen, Mandelin, Partanen, Jussila, Li, Ristimaki, Alitalo, Konttinen (bib140) 2002; 29
Onder, Mörbe, Pikor, Novkovic, Cheng, Hehlgans, Pfeffer, Becher, Waisman, Rülicke, Gommerman, Mueller, Sawa, Scandella, Ludewig (bib139) 2017; 47
Franco, Aveleira, Cavadas (bib47) 2022; 28
Khan, Awad, Oszwald, Mayr, Yin, Waltenberger, Stuppner, Lipovac, Uhrin, Breuss (bib96) 2017; 7
Besse, Nadaud, Balse, Pavoine (bib14) 2022; 11
Avraham, Daluvoy, Zampell, Yan, Haviv, Rockson, Mehrara (bib10) 2010; 177
Muñoz-Espín, Serrano (bib126) 2014; 15
Da Mesquita, Louveau, Vaccari, Smirnov, Cornelison, Kingsmore, Contarino, Onengut-Gumuscu, Farber, Raper, Viar, Powell, Baker, Dabhi, Bai, Cao, Hu, Rich, Munson, Lopes, Overall, Acton, Kipnis (bib34) 2018; 560
Nakamoto, Ito, Nishizawa, Goto, Kojo, Kumamoto, Watanabe, Majima (bib128) 2020; 23
Fankhauser, Broggi, Potin, Bordry, Jeanbart, Lund, Da Costa, Hauert, Rincon-Restrepo, Tremblay, Cabello, Homicsko, Michielin, Hanahan, Speiser, Swartz (bib41) 2017; 9
Nagai, Bridenbaugh, Gashev (bib127) 2011; 18
Petrova, Koh (bib148) 2020; 369
Feng, He, Yao, Klionsky (bib44) 2014; 24
Gulen, Samson, Keller, Schwabenland, Liu, Glück, Thacker, Favre, Mangeat, Kroese, Krimpenfort, Prinz, Ablasser (bib56) 2023; 620
Parzych, Klionsky (bib146) 2014; 20
Tidball, Flores, Welc, Wehling-Henricks, Ochi (bib171) 2021; 145
Karkkainen, Ferrell, Lawrence, Kimak, Levinson, McTigue, Alitalo, Finegold (bib88) 2000; 25
Wu, Xia, Kalionis, Wan, Sun (bib182) 2014; 2014
Huang, Caputo, Noordmans, Yazdani, Monteiro, van den Born, van Goor, Heeringa, Korstanje, Hillebrands (bib72) 2014; 9
Chevalier, Ferland, Tuchweber (bib28) 1996; 10
Iliff, Wang, Liao, Plogg, Peng, Gundersen, Benveniste, Vates, Deane, Goldman, Nagelhus, Nedergaard (bib73) 2012; 4
Hos, Bachmann, Bock, Onderka, Cursiefen (bib68) 2008; 87
Martel, Li, Fulp, Platt, Gautier, Westerterp, Bittman, Tall, Chen, Thomas, Kreisel, Swartz, Sorci-Thomas, Randolph (bib117) 2013; 123
Da Mesquita, Herz, Wall, Dykstra, de Lima, Norris, Dabhi, Kennedy, Baker, Kipnis (bib35) 2021; 7
Mahbub, Deburghgraeve, Kovacs (bib115) 2012; 32
Filelfi, Onorato, Brix, Goswami (bib45) 2021; 10
Inoue, Cheng, Huang, Hu, Kikuchi, Jiang, Piao, Sasaki, Itakura, Wu, Zhao, Lei, Yang, Zhu, Li, Sato, Koike, Kuzuya (bib74) 2017; 8
Ji (bib81) 2018; 211
Goldman, Dykstra, Smirnov, Blackburn, Da Mesquita, Kipnis, Herz (bib54) 2022; 2
Hsu, Rayasam, Kijak, Choi, Harding, Marcus, Karpus, Sandor, Fabry (bib70) 2019; 10
Akl, Nagai, Coté, Gashev (bib2) 2011; 301
Ni, Li, Chen, Bao, Wang, Li, Ruan, Wang, Sun (bib131) 2024
Lähteenvuo, Honkonen, Tervala, Tammela, Suominen, Lähteenvuo, Kholová, Alitalo, Ylä-Herttuala, Saaristo (bib102) 2011; 123
Hu, Deng, Ma, Li, Chen, Liao, Zhou, Zhang, Shao, Feng, He, Ning, Kong, Huo, He, Liu, Zhang, Adams, He, Tang, Bian, Luo (bib71) 2020; 30
Maes, Olmeda, Soengas, Agostinis (bib114) 2016; 283
Thangaswamy, Bridenbaugh, Gashev (bib169) 2012; 10
López-Otín, Blasco, Partridge, Serrano, Kroemer (bib108) 2013; 153
Smallwood, Lóp
Mazzuca (10.1016/j.mad.2024.111975_bib120) 2017; 91
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Hassan (10.1016/j.mad.2024.111975_bib61) 2021; 223
Ji (10.1016/j.mad.2024.111975_bib82) 2022; 27
Liu (10.1016/j.mad.2024.111975_bib107) 2023; 8
Huang (10.1016/j.mad.2024.111975_bib72) 2014; 9
Louveau (10.1016/j.mad.2024.111975_bib110) 2015; 523
Tarasoff-Conway (10.1016/j.mad.2024.111975_bib168) 2015; 11
Henry (10.1016/j.mad.2024.111975_bib63) 1999; 277
References_xml – volume: 11
  start-page: 1249
  year: 2022
  ident: bib14
  article-title: Early Protective Role of Inflammation in Cardiac Remodeling and Heart Failure: Focus on TNFα and Resident Macrophages
  publication-title: Cells
– volume: 8
  start-page: 200
  year: 2023
  ident: bib107
  article-title: Immunosenescence: molecular mechanisms and diseases
  publication-title: Signal Transduct. Target Ther.
– volume: 13
  year: 2023
  ident: bib195
  article-title: A novel signature of aging-related genes associated with lymphatic metastasis for survival prediction in patients with bladder cancer
  publication-title: Front. Oncol.
– volume: 49
  start-page: 381
  year: 2019
  end-page: 388
  ident: bib129
  article-title: Skeletal muscle as potential central link between sarcopenia and immune senescence
  publication-title: EBioMedicine
– volume: 20
  start-page: 12
  year: 2023
  ident: bib130
  article-title: Impact of aging on meningeal gene expression
  publication-title: Fluids Barriers CNS
– volume: 103
  start-page: 85
  year: 2022
  end-page: 96
  ident: bib105
  article-title: Drainage of senescent astrocytes from brain via meningeal lymphatic routes
  publication-title: Brain Behav. Immun.
– volume: 308
  start-page: H1065
  year: 2015
  end-page: H1077
  ident: bib51
  article-title: Regulation of inflammation and fibrosis by macrophages in lymphedema
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
– volume: 34
  start-page: 1162
  year: 2014
  end-page: 1170
  ident: bib175
  article-title: Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis
  publication-title: Arterioscler. Thromb. Vasc. Biol.
– volume: 11
  start-page: 160
  year: 2022
  ident: bib15
  article-title: Multifactorial mechanism of sarcopenia and sarcopenic obesity. Role of physical exercise, microbiota and myokines
  publication-title: Cells
– volume: 123
  start-page: 613
  year: 2011
  end-page: 620
  ident: bib102
  article-title: Growth factor therapy and autologous lymph node transfer in lymphedema
  publication-title: Circulation
– volume: 1
  year: 2016
  ident: bib50
  article-title: Diphtheria toxin-mediated ablation of lymphatic endothelial cells results in progressive lymphedema
  publication-title: JCI Insight
– volume: 9
  year: 2017
  ident: bib41
  article-title: Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma
  publication-title: Sci. Transl. Med.
– volume: 10
  start-page: 229
  year: 2019
  ident: bib70
  article-title: Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells
  publication-title: Nat. Commun.
– volume: 303
  start-page: H693
  year: 2012
  end-page: H702
  ident: bib25
  article-title: Aging-associated shifts in functional status of mast cells located by adult and aged mesenteric lymphatic vessels
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
– volume: 75
  start-page: 923
  year: 2023
  end-page: 936
  ident: bib106
  article-title: Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice
  publication-title: Arthritis Rheuma
– volume: 13
  year: 2022
  ident: bib40
  article-title: Age-related alterations in macrophage distribution and function are associated with delayed cutaneous wound healing
  publication-title: Front. Immunol.
– volume: 11
  start-page: 1234
  year: 2020
  ident: bib142
  article-title: Emerging roles of mast cells in the regulation of lymphatic immuno-physiology
  publication-title: Front. Immunol.
– volume: 20
  year: 2019
  ident: bib167
  article-title: Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages
  publication-title: EMBO Rep.
– volume: 18
  start-page: 1171
  year: 2022
  end-page: 1187
  ident: bib178
  article-title: CD137L-macrophage induce lymphatic endothelial cells autophagy to promote lymphangiogenesis in renal fibrosis
  publication-title: Int. J. Biol. Sci.
– volume: 14
  start-page: 582
  year: 2015
  end-page: 594
  ident: bib197
  article-title: Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance
  publication-title: Aging Cell
– volume: 128
  start-page: 2003
  year: 2021
  end-page: 2016
  ident: bib155
  article-title: Advances in lymphedema
  publication-title: Circ. Res.
– volume: 9
  year: 2022
  ident: bib172
  article-title: Transforming growth factor-β in tumour development
  publication-title: Front. Mol. Biosci.
– volume: 11
  year: 2015
  ident: bib153
  article-title: Age-dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of west nile virus infection
  publication-title: PLoS Pathog.
– volume: 1869
  year: 2023
  ident: bib191
  article-title: SIRT1 and SIRT6: The role in aging-related diseases
  publication-title: Biochim. Biophys. Acta Mol. Basis Dis.
– volume: 91
  year: 2017
  ident: bib120
  article-title: Role of autophagy in HIV-1 matrix protein p17-driven lymphangiogenesis
  publication-title: J. Virol.
– volume: 43
  year: 2024
  ident: bib69
  article-title: An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade
  publication-title: Cell Rep.
– volume: 218
  year: 2021
  ident: bib60
  article-title: Macroautophagy in lymphatic endothelial cells inhibits T cell-mediated autoimmunity
  publication-title: J. Exp. Med.
– volume: 20
  start-page: 421
  year: 2019
  end-page: 435
  ident: bib66
  article-title: The proteostasis network and its decline in ageing
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 153
  start-page: 1194
  year: 2013
  end-page: 1217
  ident: bib108
  article-title: The hallmarks of aging
  publication-title: Cell
– volume: 214
  start-page: 3645
  year: 2017
  end-page: 3667
  ident: bib7
  article-title: Development and plasticity of meningeal lymphatic vessels
  publication-title: J. Exp. Med.
– volume: 10
  year: 2020
  ident: bib42
  article-title: Increased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology
  publication-title: Sci. Rep.
– volume: 8
  start-page: 1434
  year: 2017
  ident: bib112
  article-title: Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
  publication-title: Nat. Commun.
– volume: 170
  year: 2024
  ident: bib135
  article-title: CCBE1 regulates the development and prevents the age-dependent regression of meningeal lymphatics
  publication-title: Biomed. Pharmacother.
– volume: 14
  start-page: 547
  year: 2014
  end-page: 558
  ident: bib147
  article-title: Inside and out: the activities of senescence in cancer
  publication-title: Nat. Rev. Cancer
– volume: 29
  start-page: 990
  year: 2022
  end-page: 1005.e10
  ident: bib113
  article-title: Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues
  publication-title: Cell Stem Cell
– volume: 560
  start-page: 185
  year: 2018
  end-page: 191
  ident: bib34
  article-title: Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease
  publication-title: Nature
– volume: 112
  year: 2023
  ident: bib43
  article-title: Hydroxysafflor yellow A regulates lymphangiogenesis and inflammation via the inhibition of PI3K on regulating AKT/mTOR and NF-κB pathway in macrophages to reduce atherosclerosis in ApoE-/- mice
  publication-title: Phytomedicine
– volume: 50
  start-page: 7981
  year: 2023
  end-page: 7993
  ident: bib124
  article-title: Thromboxane prostanoid signaling in macrophages attenuates lymphedema and facilitates lymphangiogenesis in mice: TP signaling and lymphangiogenesis
  publication-title: Mol. Biol. Rep.
– volume: 14
  start-page: 978
  year: 2023
  ident: bib184
  article-title: Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling
  publication-title: Nat. Commun
– volume: 14
  start-page: 877
  year: 2013
  end-page: 882
  ident: bib121
  article-title: Proinflammatory cytokines, aging, and age-related diseases
  publication-title: J. Am. Med. Dir. Assoc.
– volume: 20
  start-page: 566
  year: 2020
  end-page: 578
  ident: bib77
  article-title: Lymphatic endothelial cells of the lymph node
  publication-title: Nat. Rev. Immunol.
– volume: 187
  start-page: 6208
  year: 2011
  end-page: 6216
  ident: bib111
  article-title: Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue
  publication-title: J. Immunol.
– volume: 219
  year: 2022
  ident: bib30
  article-title: Infection-induced lymphatic zippering restricts fluid transport and viral dissemination from skin
  publication-title: J. Exp. Med.
– volume: 123
  start-page: 1571
  year: 2013
  end-page: 1579
  ident: bib117
  article-title: Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice
  publication-title: J. Clin. Invest.
– volume: 8
  start-page: 3065
  year: 2016
  end-page: 3090
  ident: bib132
  article-title: Mast cells and histamine are triggering the NF-κB-mediated reactions of adult and aged perilymphatic mesenteric tissues to acute inflammation
  publication-title: Aging (Albany NY)
– volume: 11
  start-page: 457
  year: 2015
  end-page: 470
  ident: bib168
  article-title: Clearance systems in the brain-implications for Alzheimer disease
  publication-title: Nat. Rev. Neurol.
– volume: 50
  start-page: 889
  year: 2002
  end-page: 896
  ident: bib78
  article-title: Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
  publication-title: J. Am. Geriatr. Soc.
– volume: 37
  start-page: 389
  year: 2002
  end-page: 394
  ident: bib65
  article-title: Immunosenescence of macrophages: reduced MHC class II gene expression
  publication-title: Exp. Gerontol.
– volume: 64
  start-page: 3737
  year: 2004
  end-page: 3740
  ident: bib62
  article-title: Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis
  publication-title: Cancer Res
– volume: 625
  start-page: 768
  year: 2024
  end-page: 777
  ident: bib187
  article-title: Nasopharyngeal lymphatic plexus is a hub for cerebrospinal fluid drainage
  publication-title: Nature
– volume: 7
  year: 2017
  ident: bib96
  article-title: Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin
  publication-title: Sci. Rep.
– volume: 10
  start-page: 1085
  year: 1996
  end-page: 1090
  ident: bib28
  article-title: Lymphatic absorption of retinol in young, mature, and old rats: influence of dietary restriction
  publication-title: FASEB J.
– volume: 523
  start-page: 337
  year: 2015
  end-page: 341
  ident: bib110
  article-title: Structural and functional features of central nervous system lymphatic vessels
  publication-title: Nature
– volume: 115
  start-page: 2316
  year: 2005
  end-page: 2319
  ident: bib95
  article-title: The crucial role of macrophages in lymphangiogenesis
  publication-title: J. Clin. Invest.
– volume: 37
  start-page: 456
  year: 1997
  end-page: 477
  ident: bib138
  article-title: Lymphatic system of the pancreas
  publication-title: Microsc. Res. Tech.
– volume: 257
  start-page: 43
  year: 2023
  end-page: 53
  ident: bib20
  article-title: Topical captopril: a promising treatment for secondary lymphedema
  publication-title: Transl. Res.
– volume: 50
  start-page: 9911
  year: 2011
  end-page: 9922
  ident: bib161
  article-title: Aging enhances the production of reactive oxygen species and bactericidal activity in peritoneal macrophages by upregulating classical activation pathways
  publication-title: Biochemistry
– volume: 572
  start-page: 62
  year: 2019
  end-page: 66
  ident: bib1
  article-title: Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
  publication-title: Nature
– volume: 3
  year: 2022
  ident: bib92
  article-title: Structural and functional changes in aged skin lymphatic vessels
  publication-title: Front. Aging
– volume: 69
  start-page: 1187
  year: 2017
  end-page: 1193
  ident: bib17
  article-title: Brief report: treatment of tumor necrosis factor-transgenic mice with anti-tumor necrosis factor restores lymphatic contractions, repairs lymphatic vessels, and may increase monocyte/macrophage egress
  publication-title: Arthritis Rheuma
– volume: 13
  start-page: 2086
  year: 2017
  end-page: 2103
  ident: bib151
  article-title: Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
  publication-title: Autophagy
– volume: 26
  year: 2016
  ident: bib39
  article-title: Non-cell-autonomous regulation of cellular senescence in cancer
  publication-title: Trends Cell Biol.
– volume: 2014
  year: 2014
  ident: bib182
  article-title: The role of oxidative stress and inflammation in cardiovascular aging
  publication-title: Biomed. Res. Int.
– volume: 40
  start-page: 2583
  year: 2015
  end-page: 2599
  ident: bib79
  article-title: The glymphatic system: a beginner's guide
  publication-title: Neurochem. Res.
– volume: 145
  year: 2021
  ident: bib171
  article-title: Aging of the immune system and impaired muscle regeneration: a failure of immunomodulation of adult myogenesis
  publication-title: Exp. Gerontol.
– volume: 148
  start-page: 1231
  year: 2023
  end-page: 1249
  ident: bib98
  article-title: Lymphatic sphingosine-1-phosphate signaling aggravates lymphatic dysfunction and tissue inflammation
  publication-title: Circulation
– volume: 12
  start-page: 109
  year: 2021
  ident: bib193
  article-title: Lymphangiogenesis in renal fibrosis arises from macrophages via VEGF-C/VEGFR3-dependent autophagy and polarization
  publication-title: Cell Death Dis.
– volume: 283
  start-page: 106
  year: 2019
  end-page: 119
  ident: bib122
  article-title: Early rescue of lymphatic function limits atherosclerosis progression in Ldlr-/- mice
  publication-title: Atherosclerosis
– volume: 41
  start-page: 487
  year: 2011
  end-page: 497
  ident: bib97
  article-title: Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol-rich and calcified atherosclerotic lesions
  publication-title: Eur. J. Clin. Invest.
– volume: 141
  start-page: 985
  year: 2021
  end-page: 992
  ident: bib181
  article-title: Connective tissue and fibroblast senescence in skin aging
  publication-title: J. Invest. Dermatol.
– volume: 301
  start-page: H1828
  year: 2011
  end-page: H1840
  ident: bib2
  article-title: Mesenteric lymph flow in adult and aged rats
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
– volume: 88
  start-page: 1021
  year: 2010
  end-page: 1027
  ident: bib174
  article-title: Mitochondria and aging in the vascular system
  publication-title: J. Mol. Med. (Berl. )
– volume: 211
  start-page: 261
  year: 2018
  end-page: 269
  ident: bib81
  article-title: Recent advances and new insights into muscular lymphangiogenesis in health and disease
  publication-title: Life Sci.
– volume: 18
  start-page: 1166
  year: 2011
  end-page: 1172
  ident: bib89
  article-title: Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle
  publication-title: Gene Ther.
– volume: 32
  start-page: 18
  year: 2012
  end-page: 26
  ident: bib115
  article-title: Advanced age impairs macrophage polarization
  publication-title: J. Interferon Cytokine Res.
– volume: 19
  year: 2020
  ident: bib24
  article-title: The involvement of stress granules in aging and aging-associated diseases
  publication-title: Aging Cell
– year: 2024
  ident: bib131
  article-title: LECs regulate neutrophil clearance through IL-17RC/CMTM4/NF-kappaB axis at sites of inflammation or infection.
  publication-title: Mucosal Immunol.
– volume: 17
  start-page: 7
  year: 2016
  end-page: 19
  ident: bib48
  article-title: Inflammaging decreases adaptive and innate immune responses in mice and humans
  publication-title: Biogerontology
– volume: 28
  start-page: 97
  year: 2022
  end-page: 109
  ident: bib47
  article-title: Skin senescence: mechanisms and impact on whole-body aging
  publication-title: Trends Mol. Med.
– volume: 577
  start-page: 689
  year: 2020
  end-page: 694
  ident: bib163
  article-title: VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours
  publication-title: Nature
– volume: 212
  start-page: 327
  year: 2010
  end-page: 332
  ident: bib134
  article-title: Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men
  publication-title: Atherosclerosis
– volume: 18
  start-page: 965
  year: 2017
  ident: bib141
  article-title: Aged Lymphatic Vessels and Mast Cells in Perilymphatic Tissues
  publication-title: Int. J. Mol. Sci.
– volume: 124
  start-page: 3863
  year: 2014
  end-page: 3878
  ident: bib36
  article-title: VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease
  publication-title: J. Clin. Invest.
– volume: 10
  start-page: 1054
  year: 2021
  ident: bib173
  article-title: Manifestations of age on autophagy, mitophagy and lysosomes in skeletal muscle
  publication-title: Cells
– volume: 186
  start-page: 382
  year: 2023
  end-page: 397.e24
  ident: bib16
  article-title: Lymphatic vessels in bone support regeneration after injury
  publication-title: Cell
– volume: 205
  start-page: 60
  year: 2005
  end-page: 71
  ident: bib165
  article-title: Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes
  publication-title: Immunol. Rev.
– volume: 9
  year: 2014
  ident: bib72
  article-title: Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice
  publication-title: PLoS One
– volume: 69
  start-page: 897
  year: 2012
  end-page: 914
  ident: bib80
  article-title: Macrophages are important mediators of either tumor- or inflammation-induced lymphangiogenesis
  publication-title: Cell Mol. Life Sci.
– volume: 30
  start-page: 325
  year: 2009
  end-page: 333
  ident: bib144
  article-title: Human innate immunosenescence: causes and consequences for immunity in old age
  publication-title: Trends Immunol.
– volume: 7
  start-page: 199
  year: 2001
  end-page: 205
  ident: bib116
  article-title: Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
  publication-title: Nat. Med.
– volume: 111
  start-page: 4571
  year: 2008
  end-page: 4579
  ident: bib137
  article-title: Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis.
  publication-title: Blood
– volume: 87
  start-page: 357
  year: 2020
  end-page: 369
  ident: bib194
  article-title: Impairment of the glymphatic pathway and putative meningeal lymphatic vessels in the aging human
  publication-title: Ann. Neurol.
– volume: 17
  start-page: 1344
  year: 2016
  end-page: 1356
  ident: bib4
  article-title: Macrophage-induced lymphangiogenesis and metastasis following paclitaxel chemotherapy is regulated by VEGFR3
  publication-title: Cell Rep.
– volume: 104
  start-page: 1302
  year: 2009
  end-page: 1312
  ident: bib6
  article-title: Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle
  publication-title: Circ. Res.
– volume: 8
  year: 2021
  ident: bib11
  article-title: Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer
  publication-title: Front. Cardiovasc. Med.
– volume: 8
  start-page: 370
  year: 2017
  end-page: 385
  ident: bib74
  article-title: Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice
  publication-title: J. Cachex-.-. Sarcopenia Muscle
– volume: 129
  start-page: 1292
  year: 2009
  end-page: 1298
  ident: bib86
  article-title: Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis
  publication-title: J. Invest. Dermatol.
– volume: 92
  start-page: 1098
  year: 2003
  end-page: 1106
  ident: bib154
  article-title: VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses
  publication-title: Circ. Res.
– volume: 41
  start-page: 2217
  year: 2014
  end-page: 2228
  ident: bib83
  article-title: Rapamycin inhibition of CFA-induced lymphangiogenesis in PLN is independent of mast cells
  publication-title: Mol. Biol. Rep.
– volume: 277
  start-page: H508
  year: 1999
  end-page: H514
  ident: bib63
  article-title: Permeation of the luminal capillary glycocalyx is determined by hyaluronan
  publication-title: Am. J. Physiol.
– volume: 7
  year: 2016
  ident: bib27
  article-title: Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
  publication-title: Nat. Commun.
– volume: 283
  start-page: 25
  year: 2016
  end-page: 38
  ident: bib114
  article-title: Vesicular trafficking mechanisms in endothelial cells as modulators of the tumor vasculature and targets of antiangiogenic therapies
  publication-title: FEBS J.
– volume: 128
  start-page: 1238
  year: 2018
  end-page: 1246
  ident: bib64
  article-title: Mechanisms and functions of cellular senescence
  publication-title: J. Clin. Invest.
– volume: 7
  start-page: 1418
  year: 2015
  end-page: 1425
  ident: bib133
  article-title: VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption
  publication-title: EMBO Mol. Med.
– volume: 111
  start-page: 717
  year: 2003
  end-page: 725
  ident: bib188
  article-title: VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema
  publication-title: J. Clin. Invest.
– volume: 7
  year: 2021
  ident: bib35
  article-title: Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology
  publication-title: Sci. Adv.
– volume: 25
  start-page: 153
  year: 2000
  end-page: 159
  ident: bib88
  article-title: Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
  publication-title: Nat. Genet.
– volume: 20
  start-page: 460
  year: 2014
  end-page: 473
  ident: bib146
  article-title: An overview of autophagy: morphology, mechanism, and regulation
  publication-title: Antioxid. Redox Signal
– volume: 115
  start-page: 2363
  year: 2005
  end-page: 2372
  ident: bib118
  article-title: Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
  publication-title: J. Clin. Invest.
– volume: 99
  start-page: 427
  year: 2019
  end-page: 511
  ident: bib103
  article-title: Sarcopenia: aging-related loss of muscle mass and function
  publication-title: Physiol. Rev.
– volume: 19
  start-page: 579
  year: 2018
  end-page: 593
  ident: bib59
  article-title: Autophagy as a promoter of longevity: insights from model organisms
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 23
  start-page: 395
  year: 2020
  end-page: 410
  ident: bib128
  article-title: Lymphangiogenesis and accumulation of reparative macrophages contribute to liver repair after hepatic ischemia-reperfusion injury
  publication-title: Angiogenesis
– volume: 141
  start-page: 1087
  year: 2021
  end-page: 1095
  ident: bib149
  article-title: Inflammaging and the skin
  publication-title: J. Invest. Dermatol.
– volume: 13
  start-page: 203
  year: 2022
  ident: bib3
  article-title: Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes
  publication-title: Nat. Commun.
– volume: 5
  start-page: 99
  year: 2010
  end-page: 118
  ident: bib31
  article-title: The senescence-associated secretory phenotype: the dark side of tumor suppression
  publication-title: Annu. Rev. Pathol.
– volume: 64
  start-page: 279
  year: 2004
  end-page: 286
  ident: bib84
  article-title: Expression of VEGFR-3 and 5′-nase in regenerating lymphatic vessels of the cutaneous wound healing
  publication-title: Microsc. Res. Tech.
– volume: 9
  start-page: 207
  year: 2018
  end-page: 299
  ident: bib18
  article-title: Lymphatic vessel network structure and physiology
  publication-title: Compr. Physiol.
– volume: 12
  start-page: 345
  year: 2013
  end-page: 357
  ident: bib75
  article-title: Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice
  publication-title: Aging Cell
– volume: 3
  start-page: 23
  year: 2003
  end-page: 35
  ident: bib55
  article-title: Alternative activation of macrophages
  publication-title: Nat. Rev. Immunol.
– volume: 594
  start-page: 5749
  year: 2016
  end-page: 5768
  ident: bib158
  article-title: Lymphatic pumping: mechanics, mechanisms and malfunction
  publication-title: J. Physiol.
– volume: 2
  start-page: 704
  year: 2022
  end-page: 713
  ident: bib54
  article-title: Age-associated suppression of exploratory activity during sickness is linked to meningeal lymphatic dysfunction and microglia activation
  publication-title: Nat. Aging
– volume: 220
  year: 2023
  ident: bib156
  article-title: Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage
  publication-title: J. Exp. Med.
– volume: 46
  start-page: 2286
  year: 2016
  end-page: 2301
  ident: bib150
  article-title: Aging of the immune system: Focus on inflammation and vaccination
  publication-title: Eur. J. Immunol.
– volume: 13
  start-page: 19920
  year: 2021
  end-page: 19941
  ident: bib21
  article-title: Cellular senescence in lymphoid organs and immunosenescence
  publication-title: Aging (Albany NY)
– volume: 177
  start-page: 3202
  year: 2010
  end-page: 3214
  ident: bib10
  article-title: Blockade of transforming growth factor-beta1 accelerates lymphatic regeneration during wound repair
  publication-title: Am. J. Pathol.
– volume: 10
  start-page: 470
  year: 2019
  ident: bib91
  article-title: Regulation of Immune Function by the Lymphatic System in Lymphedema
  publication-title: Front. Immunol.
– volume: 223
  year: 2021
  ident: bib61
  article-title: Benzimidazole-galactosides bind selectively to the Galectin-8 N-Terminal domain: structure-based design and optimisation
  publication-title: Eur. J. Med. Chem.
– volume: 112
  start-page: 1129
  year: 2008
  end-page: 1138
  ident: bib186
  article-title: Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways
  publication-title: Blood
– volume: 35
  start-page: 12
  year: 2023
  end-page: 35
  ident: bib109
  article-title: Meta-hallmarks of aging and cancer
  publication-title: Cell Metab.
– volume: 8
  start-page: 18
  year: 2009
  end-page: 30
  ident: bib29
  article-title: Molecular inflammation: underpinnings of aging and age-related diseases
  publication-title: Ageing Res. Rev.
– volume: 119
  year: 2022
  ident: bib162
  article-title: Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 81
  year: 2020
  ident: bib192
  article-title: M1 macrophages accelerate renal glomerular endothelial cell senescence through reactive oxygen species accumulation in streptozotocin-induced diabetic mice
  publication-title: Int. Immunopharmacol.
– volume: 375
  start-page: 671
  year: 2022
  end-page: 677
  ident: bib164
  article-title: Caloric restriction in humans reveals immunometabolic regulators of health span
  publication-title: Science
– volume: 13
  start-page: 709
  year: 2018
  end-page: 716
  ident: bib179
  article-title: Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease
  publication-title: Neural Regen. Res.
– volume: 66
  start-page: 419
  year: 2020
  end-page: 426
  ident: bib76
  article-title: Lymphatic capillaries in aging
  publication-title: Gerontology
– volume: 64
  start-page: 620
  year: 2021
  end-page: 628
  ident: bib94
  article-title: Morphological and biochemical changes of lymphatic vessels in the soleus muscle of mice after hindlimb unloading
  publication-title: Muscle Nerve
– volume: 47
  start-page: 80
  year: 2017
  end-page: 92.e4
  ident: bib139
  article-title: Lymphatic endothelial cells control initiation of lymph node organogenesis
  publication-title: Immunity
– volume: 369
  year: 2020
  ident: bib148
  article-title: Biological functions of lymphatic vessels
  publication-title: Science
– volume: 65
  start-page: 106
  year: 2019
  end-page: 119
  ident: bib13
  article-title: The glymphatic system and waste clearance with brain aging: a review
  publication-title: Gerontology
– volume: 48
  start-page: 16
  year: 2019
  end-page: 31
  ident: bib32
  article-title: Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis
  publication-title: Age Ageing
– volume: 136
  start-page: 706
  year: 2016
  end-page: 714
  ident: bib136
  article-title: Excess lymphangiogenesis cooperatively induced by macrophages and CD4(+) T cells drives the pathogenesis of lymphedema
  publication-title: J. Invest. Dermatol.
– volume: 133
  start-page: 1019
  year: 2008
  end-page: 1031
  ident: bib99
  article-title: Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
  publication-title: Cell
– volume: 11
  start-page: 466
  year: 2022
  end-page: 478
  ident: bib12
  article-title: Lymphangiogenesis contributes to exercise-induced physiological cardiac growth
  publication-title: J. Sport Health Sci.
– volume: 9
  year: 2021
  ident: bib100
  article-title: Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
  publication-title: Front. Cell Dev. Biol.
– volume: 128
  start-page: 87
  year: 2020
  end-page: 99
  ident: bib104
  article-title: Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation
  publication-title: J. Appl. Physiol. (1985)
– volume: 92
  start-page: 4337
  year: 1995
  end-page: 4341
  ident: bib26
  article-title: Oxidative DNA damage and senescence of human diploid fibroblast cells
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 11
  start-page: 6602
  year: 2019
  end-page: 6613
  ident: bib160
  article-title: Pathophysiology of aged lymphatic vessels
  publication-title: Aging
– volume: 18
  year: 2019
  ident: bib170
  article-title: Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates
  publication-title: Aging Cell
– volume: 15
  year: 2020
  ident: bib190
  article-title: TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals
  publication-title: PLoS One
– volume: 1
  start-page: 634
  year: 2021
  end-page: 650
  ident: bib5
  article-title: Autophagy in healthy aging and disease
  publication-title: Nat. Aging
– volume: 89
  start-page: 285
  year: 2017
  end-page: 299
  ident: bib49
  article-title: Immune System Dysfunction in the Elderly
  publication-title: . Acad. Bras. Cienc.
– volume: 27
  start-page: 955
  year: 2021
  end-page: 970
  ident: bib166
  article-title: Homeostatic maintenance of the lymphatic vasculature
  publication-title: Trends Mol. Med.
– volume: 18
  start-page: 463
  year: 2011
  end-page: 473
  ident: bib127
  article-title: Aging-associated alterations in contractility of rat mesenteric lymphatic vessels
  publication-title: Microcirculation
– volume: 371
  year: 2021
  ident: bib143
  article-title: Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
  publication-title: Science
– volume: 10
  start-page: 5129
  year: 2021
  ident: bib189
  article-title: Lymphaticovenous anastomosis for age-related lymphedema
  publication-title: J. Clin. Med.
– volume: 273
  start-page: 70
  year: 1996
  end-page: 74
  ident: bib123
  article-title: The aging immune system: primer and prospectus
  publication-title: Science
– volume: 20
  start-page: 77
  year: 2020
  end-page: 88
  ident: bib101
  article-title: The dynamic interplay between mast cells, aging/cellular senescence, and liver disease
  publication-title: Gene Expr.
– volume: 123
  start-page: 2803
  year: 2013
  end-page: 2815
  ident: bib180
  article-title: Immune cells control skin lymphatic electrolyte homeostasis and blood pressure
  publication-title: J. Clin. Invest.
– volume: 4
  start-page: 147ra111
  year: 2012
  ident: bib73
  article-title: A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β
  publication-title: Sci. Transl. Med.
– volume: 15
  start-page: 2873
  year: 2023
  ident: bib159
  article-title: Glycocalyx-sodium interaction in vascular endothelium
  publication-title: Nutrients
– volume: 132
  year: 2022
  ident: bib52
  article-title: Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation
  publication-title: J. Clin. Invest.
– volume: 3
  start-page: 829
  year: 2023
  end-page: 845
  ident: bib38
  article-title: Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters
  publication-title: Nat. Aging
– start-page: 724
  year: 2023
  end-page: 740
  ident: bib185
  article-title: Signaling mechanisms underlying lymphatic vessel dysfunction in skin aging and possible anti-aging strategies
  publication-title: Biogerontology
– volume: 17
  start-page: 1183
  year: 2003
  end-page: 1185
  ident: bib33
  article-title: Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries
  publication-title: FASEB J.
– volume: 301
  start-page: H48
  year: 2011
  end-page: H60
  ident: bib37
  article-title: Determinants of valve gating in collecting lymphatic vessels from rat mesentery
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
– volume: 10
  start-page: 293
  year: 2021
  ident: bib45
  article-title: Lymphatic senescence: current updates and perspectives
  publication-title: Biology
– volume: 91
  start-page: 1314
  year: 2011
  end-page: 1325
  ident: bib90
  article-title: Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema
  publication-title: Lab. Invest.
– volume: 11
  start-page: 35
  year: 2013
  end-page: 42
  ident: bib19
  article-title: Lymphatic muscle cells in rat mesenteric lymphatic vessels of various ages
  publication-title: Lymphat. Res. Biol.
– volume: 13
  start-page: 153
  year: 2014
  end-page: 161
  ident: bib196
  article-title: Inflammaging in skin and other tissues - the roles of complement system and macrophage
  publication-title: Inflamm. Allergy Drug Targets
– volume: 60
  start-page: 2666
  year: 2009
  end-page: 2676
  ident: bib57
  article-title: Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis
  publication-title: Arthritis Rheum.
– volume: 10
  start-page: 53
  year: 2012
  end-page: 62
  ident: bib169
  article-title: Evidence of increased oxidative stress in aged mesenteric lymphatic vessels
  publication-title: Lymphat. Res. Biol.
– volume: 100
  start-page: 697
  year: 2022
  end-page: 712
  ident: bib157
  article-title: Clinical perspectives on the age-related increase of immunosuppressive activity
  publication-title: J. Mol. Med.
– volume: 29
  start-page: 39
  year: 2002
  end-page: 45
  ident: bib140
  article-title: Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium
  publication-title: J. Rheumatol.
– volume: 13
  year: 2022
  ident: bib177
  article-title: Immunosenescence, aging and successful aging
  publication-title: Front. Immunol.
– volume: 132
  start-page: 1203
  year: 2023
  end-page: 1225
  ident: bib8
  article-title: Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells
  publication-title: Circ. Res.
– volume: 35
  start-page: 785
  year: 2018
  end-page: 796
  ident: bib85
  article-title: Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis
  publication-title: Clin. Exp. Metastas-.-.
– volume: 18
  start-page: 489
  year: 2015
  end-page: 498
  ident: bib87
  article-title: Decline of lymphatic vessel density and function in murine skin during aging
  publication-title: Angiogenesis
– volume: 43
  start-page: 1
  year: 2020
  end-page: 17
  ident: bib53
  article-title: How inflammation blunts innate immunity in aging
  publication-title: Interdiscip. Top. Gerontol. Geriatr.
– volume: 13
  start-page: 22544
  year: 2021
  end-page: 22555
  ident: bib58
  article-title: Glaucocalyxin B inhibits cartilage inflammatory injury in rheumatoid arthritis by regulating M1 polarization of synovial macrophages through NF-κB pathway
  publication-title: Aging (Albany NY)
– volume: 62
  start-page: 17
  year: 2021
  ident: bib176
  article-title: Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1+ macrophage infiltration
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 81
  start-page: 19
  year: 2019
  end-page: 41
  ident: bib67
  article-title: Maintenance of skeletal muscle mitochondria in health, exercise, and aging
  publication-title: Annu. Rev. Physiol.
– volume: 14
  start-page: 2087
  year: 2000
  end-page: 2096
  ident: bib145
  article-title: VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues
  publication-title: FASEB J.
– volume: 170
  start-page: 1178
  year: 2007
  end-page: 1191
  ident: bib119
  article-title: Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
  publication-title: Am. J. Pathol.
– volume: 24
  start-page: 24
  year: 2014
  end-page: 41
  ident: bib44
  article-title: The machinery of macroautophagy
  publication-title: Cell Res
– volume: 87
  start-page: 427
  year: 2008
  end-page: 432
  ident: bib68
  article-title: Age-related changes in murine limbal lymphatic vessels and corneal lymphangiogenesis
  publication-title: Exp. Eye Res.
– volume: 123
  start-page: 958
  year: 2013
  end-page: 965
  ident: bib125
  article-title: Causes, consequences, and reversal of immune system aging
  publication-title: J. Clin. Invest.
– volume: 212
  start-page: 991
  year: 2015
  end-page: 999
  ident: bib9
  article-title: A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
  publication-title: J. Exp. Med.
– volume: 620
  start-page: 374
  year: 2023
  end-page: 380
  ident: bib56
  article-title: cGAS-STING drives ageing-related inflammation and neurodegeneration
  publication-title: Nature
– volume: 99
  start-page: 1047
  year: 2019
  end-page: 1078
  ident: bib23
  article-title: Cellular senescence: aging, cancer, and injury
  publication-title: Physiol. Rev.
– volume: 27
  start-page: 1837
  year: 2022
  end-page: 1856
  ident: bib82
  article-title: The role of lymphangiogenesis in cardiovascular diseases and heart transplantation
  publication-title: Heart Fail. Rev.
– volume: 14
  start-page: 576
  year: 2018
  end-page: 590
  ident: bib46
  article-title: Inflammaging: a new immune-metabolic viewpoint for age-related diseases
  publication-title: Nat. Rev. Endocrinol.
– volume: 15
  start-page: 482
  year: 2014
  end-page: 496
  ident: bib126
  article-title: Cellular senescence: from physiology to pathology
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 10
  start-page: 3148
  year: 2021
  ident: bib22
  article-title: Aging-related cellular, structural and functional changes in the lymph nodes: a significant component of immunosenescence? An overview
  publication-title: Cells
– volume: 72
  year: 2021
  ident: bib93
  article-title: Autophagy and the hallmarks of aging
  publication-title: Ageing Res. Rev.
– volume: 40
  start-page: 263
  year: 2020
  end-page: 275
  ident: bib183
  article-title: Impaired meningeal lymphatic vessel development worsens stroke outcome
  publication-title: J. Cereb. Blood Flow. Metab.
– volume: 317
  start-page: E85
  year: 2019
  end-page: E98
  ident: bib152
  article-title: Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse
  publication-title: Am. J. Physiol. Endocrinol. Metab.
– volume: 30
  start-page: 229
  year: 2020
  end-page: 243
  ident: bib71
  article-title: Meningeal lymphatic vessels regulate brain tumor drainage and immunity
  publication-title: Cell Res
– volume: 7
  start-page: 199
  issue: 2
  year: 2001
  ident: 10.1016/j.mad.2024.111975_bib116
  article-title: Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
  publication-title: Nat. Med.
  doi: 10.1038/84651
– volume: 7
  year: 2017
  ident: 10.1016/j.mad.2024.111975_bib96
  article-title: Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin
  publication-title: Sci. Rep.
– volume: 17
  start-page: 1344
  issue: 5
  year: 2016
  ident: 10.1016/j.mad.2024.111975_bib4
  article-title: Macrophage-induced lymphangiogenesis and metastasis following paclitaxel chemotherapy is regulated by VEGFR3
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.09.083
– volume: 112
  start-page: 1129
  issue: 4
  year: 2008
  ident: 10.1016/j.mad.2024.111975_bib186
  article-title: Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways
  publication-title: Blood
  doi: 10.1182/blood-2007-11-125203
– volume: 112
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib43
  article-title: Hydroxysafflor yellow A regulates lymphangiogenesis and inflammation via the inhibition of PI3K on regulating AKT/mTOR and NF-κB pathway in macrophages to reduce atherosclerosis in ApoE-/- mice
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2023.154684
– volume: 46
  start-page: 2286
  issue: 10
  year: 2016
  ident: 10.1016/j.mad.2024.111975_bib150
  article-title: Aging of the immune system: Focus on inflammation and vaccination
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201546178
– volume: 205
  start-page: 60
  year: 2005
  ident: 10.1016/j.mad.2024.111975_bib165
  article-title: Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes
  publication-title: Immunol. Rev.
  doi: 10.1111/j.0105-2896.2005.00260.x
– volume: 23
  start-page: 395
  issue: 3
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib128
  article-title: Lymphangiogenesis and accumulation of reparative macrophages contribute to liver repair after hepatic ischemia-reperfusion injury
  publication-title: Angiogenesis
  doi: 10.1007/s10456-020-09718-w
– volume: 123
  start-page: 958
  issue: 3
  year: 2013
  ident: 10.1016/j.mad.2024.111975_bib125
  article-title: Causes, consequences, and reversal of immune system aging
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI64096
– volume: 11
  start-page: 466
  issue: 4
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib12
  article-title: Lymphangiogenesis contributes to exercise-induced physiological cardiac growth
  publication-title: J. Sport Health Sci.
  doi: 10.1016/j.jshs.2022.02.005
– volume: 8
  start-page: 3065
  issue: 11
  year: 2016
  ident: 10.1016/j.mad.2024.111975_bib132
  article-title: Mast cells and histamine are triggering the NF-κB-mediated reactions of adult and aged perilymphatic mesenteric tissues to acute inflammation
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.101113
– volume: 12
  start-page: 345
  issue: 3
  year: 2013
  ident: 10.1016/j.mad.2024.111975_bib75
  article-title: Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice
  publication-title: Aging Cell
  doi: 10.1111/acel.12062
– volume: 50
  start-page: 7981
  issue: 10
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib124
  article-title: Thromboxane prostanoid signaling in macrophages attenuates lymphedema and facilitates lymphangiogenesis in mice: TP signaling and lymphangiogenesis
  publication-title: Mol. Biol. Rep.
  doi: 10.1007/s11033-023-08620-0
– volume: 81
  start-page: 19
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib67
  article-title: Maintenance of skeletal muscle mitochondria in health, exercise, and aging
  publication-title: Annu. Rev. Physiol.
  doi: 10.1146/annurev-physiol-020518-114310
– volume: 170
  start-page: 1178
  issue: 4
  year: 2007
  ident: 10.1016/j.mad.2024.111975_bib119
  article-title: Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
  publication-title: Am. J. Pathol.
  doi: 10.2353/ajpath.2007.060018
– volume: 218
  issue: 6
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib60
  article-title: Macroautophagy in lymphatic endothelial cells inhibits T cell-mediated autoimmunity
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20201776
– volume: 25
  start-page: 153
  issue: 2
  year: 2000
  ident: 10.1016/j.mad.2024.111975_bib88
  article-title: Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
  publication-title: Nat. Genet.
  doi: 10.1038/75997
– volume: 1869
  issue: 7
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib191
  article-title: SIRT1 and SIRT6: The role in aging-related diseases
  publication-title: Biochim. Biophys. Acta Mol. Basis Dis.
  doi: 10.1016/j.bbadis.2023.166815
– volume: 4
  start-page: 147ra111
  issue: 147
  year: 2012
  ident: 10.1016/j.mad.2024.111975_bib73
  article-title: A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3003748
– volume: 91
  start-page: 1314
  issue: 9
  year: 2011
  ident: 10.1016/j.mad.2024.111975_bib90
  article-title: Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema
  publication-title: Lab. Invest.
  doi: 10.1038/labinvest.2011.84
– volume: 75
  start-page: 923
  issue: 6
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib106
  article-title: Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice
  publication-title: Arthritis Rheuma
  doi: 10.1002/art.42441
– volume: 14
  start-page: 576
  issue: 10
  year: 2018
  ident: 10.1016/j.mad.2024.111975_bib46
  article-title: Inflammaging: a new immune-metabolic viewpoint for age-related diseases
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/s41574-018-0059-4
– volume: 13
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib177
  article-title: Immunosenescence, aging and successful aging
  publication-title: Front. Immunol.
– volume: 19
  issue: 4
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib24
  article-title: The involvement of stress granules in aging and aging-associated diseases
  publication-title: Aging Cell
  doi: 10.1111/acel.13136
– volume: 81
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib192
  article-title: M1 macrophages accelerate renal glomerular endothelial cell senescence through reactive oxygen species accumulation in streptozotocin-induced diabetic mice
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2020.106294
– volume: 40
  start-page: 2583
  issue: 12
  year: 2015
  ident: 10.1016/j.mad.2024.111975_bib79
  article-title: The glymphatic system: a beginner's guide
  publication-title: Neurochem. Res.
  doi: 10.1007/s11064-015-1581-6
– volume: 43
  issue: 4
  year: 2024
  ident: 10.1016/j.mad.2024.111975_bib69
  article-title: An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2024.114020
– volume: 9
  issue: 3
  year: 2014
  ident: 10.1016/j.mad.2024.111975_bib72
  article-title: Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0091850
– volume: 212
  start-page: 327
  issue: 1
  year: 2010
  ident: 10.1016/j.mad.2024.111975_bib134
  article-title: Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2010.05.026
– volume: 187
  start-page: 6208
  issue: 12
  year: 2011
  ident: 10.1016/j.mad.2024.111975_bib111
  article-title: Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1102188
– volume: 301
  start-page: H1828
  issue: 5
  year: 2011
  ident: 10.1016/j.mad.2024.111975_bib2
  article-title: Mesenteric lymph flow in adult and aged rats
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00538.2011
– volume: 41
  start-page: 487
  issue: 5
  year: 2011
  ident: 10.1016/j.mad.2024.111975_bib97
  article-title: Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol-rich and calcified atherosclerotic lesions
  publication-title: Eur. J. Clin. Invest.
  doi: 10.1111/j.1365-2362.2010.02431.x
– volume: 523
  start-page: 337
  issue: 7560
  year: 2015
  ident: 10.1016/j.mad.2024.111975_bib110
  article-title: Structural and functional features of central nervous system lymphatic vessels
  publication-title: Nature
  doi: 10.1038/nature14432
– volume: 43
  start-page: 1
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib53
  article-title: How inflammation blunts innate immunity in aging
  publication-title: Interdiscip. Top. Gerontol. Geriatr.
  doi: 10.1159/000504480
– volume: 277
  start-page: H508
  issue: 2
  year: 1999
  ident: 10.1016/j.mad.2024.111975_bib63
  article-title: Permeation of the luminal capillary glycocalyx is determined by hyaluronan
  publication-title: Am. J. Physiol.
– volume: 9
  issue: 407
  year: 2017
  ident: 10.1016/j.mad.2024.111975_bib41
  article-title: Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aal4712
– volume: 186
  start-page: 382
  issue: 2
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib16
  article-title: Lymphatic vessels in bone support regeneration after injury
  publication-title: Cell
  doi: 10.1016/j.cell.2022.12.031
– volume: 283
  start-page: 106
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib122
  article-title: Early rescue of lymphatic function limits atherosclerosis progression in Ldlr-/- mice
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2019.01.031
– volume: 223
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib61
  article-title: Benzimidazole-galactosides bind selectively to the Galectin-8 N-Terminal domain: structure-based design and optimisation
  publication-title: Eur. J. Med. Chem.
  doi: 10.1016/j.ejmech.2021.113664
– volume: 303
  start-page: H693
  issue: 6
  year: 2012
  ident: 10.1016/j.mad.2024.111975_bib25
  article-title: Aging-associated shifts in functional status of mast cells located by adult and aged mesenteric lymphatic vessels
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00378.2012
– volume: 15
  start-page: 482
  issue: 7
  year: 2014
  ident: 10.1016/j.mad.2024.111975_bib126
  article-title: Cellular senescence: from physiology to pathology
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3823
– volume: 18
  start-page: 463
  issue: 6
  year: 2011
  ident: 10.1016/j.mad.2024.111975_bib127
  article-title: Aging-associated alterations in contractility of rat mesenteric lymphatic vessels
  publication-title: Microcirculation
  doi: 10.1111/j.1549-8719.2011.00107.x
– volume: 18
  issue: 1
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib170
  article-title: Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates
  publication-title: Aging Cell
  doi: 10.1111/acel.12865
– volume: 11
  issue: 7
  year: 2015
  ident: 10.1016/j.mad.2024.111975_bib153
  article-title: Age-dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of west nile virus infection
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1005027
– volume: 87
  start-page: 357
  issue: 3
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib194
  article-title: Impairment of the glymphatic pathway and putative meningeal lymphatic vessels in the aging human
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.25670
– volume: 9
  start-page: 207
  issue: 1
  year: 2018
  ident: 10.1016/j.mad.2024.111975_bib18
  article-title: Lymphatic vessel network structure and physiology
  publication-title: Compr. Physiol.
  doi: 10.1002/cphy.c180015
– volume: 10
  issue: 1
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib42
  article-title: Increased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-67987-3
– volume: 317
  start-page: E85
  issue: 1
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib152
  article-title: Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00422.2018
– volume: 10
  start-page: 53
  issue: 2
  year: 2012
  ident: 10.1016/j.mad.2024.111975_bib169
  article-title: Evidence of increased oxidative stress in aged mesenteric lymphatic vessels
  publication-title: Lymphat. Res. Biol.
  doi: 10.1089/lrb.2011.0022
– volume: 13
  start-page: 22544
  issue: 18
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib58
  article-title: Glaucocalyxin B inhibits cartilage inflammatory injury in rheumatoid arthritis by regulating M1 polarization of synovial macrophages through NF-κB pathway
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.203567
– volume: 136
  start-page: 706
  issue: 3
  year: 2016
  ident: 10.1016/j.mad.2024.111975_bib136
  article-title: Excess lymphangiogenesis cooperatively induced by macrophages and CD4(+) T cells drives the pathogenesis of lymphedema
  publication-title: J. Invest. Dermatol.
  doi: 10.1016/j.jid.2015.12.001
– volume: 115
  start-page: 2363
  issue: 9
  year: 2005
  ident: 10.1016/j.mad.2024.111975_bib118
  article-title: Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI23874
– volume: 1
  issue: 15
  year: 2016
  ident: 10.1016/j.mad.2024.111975_bib50
  article-title: Diphtheria toxin-mediated ablation of lymphatic endothelial cells results in progressive lymphedema
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.84095
– volume: 24
  start-page: 24
  issue: 1
  year: 2014
  ident: 10.1016/j.mad.2024.111975_bib44
  article-title: The machinery of macroautophagy
  publication-title: Cell Res
  doi: 10.1038/cr.2013.168
– volume: 14
  start-page: 547
  issue: 8
  year: 2014
  ident: 10.1016/j.mad.2024.111975_bib147
  article-title: Inside and out: the activities of senescence in cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3773
– volume: 141
  start-page: 1087
  issue: 4S
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib149
  article-title: Inflammaging and the skin
  publication-title: J. Invest. Dermatol.
  doi: 10.1016/j.jid.2020.11.006
– volume: 625
  start-page: 768
  issue: 7996
  year: 2024
  ident: 10.1016/j.mad.2024.111975_bib187
  article-title: Nasopharyngeal lymphatic plexus is a hub for cerebrospinal fluid drainage
  publication-title: Nature
  doi: 10.1038/s41586-023-06899-4
– volume: 308
  start-page: H1065
  issue: 9
  year: 2015
  ident: 10.1016/j.mad.2024.111975_bib51
  article-title: Regulation of inflammation and fibrosis by macrophages in lymphedema
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00598.2014
– volume: 47
  start-page: 80
  issue: 1
  year: 2017
  ident: 10.1016/j.mad.2024.111975_bib139
  article-title: Lymphatic endothelial cells control initiation of lymph node organogenesis
  publication-title: Immunity
  doi: 10.1016/j.immuni.2017.05.008
– volume: 8
  start-page: 18
  issue: 1
  year: 2009
  ident: 10.1016/j.mad.2024.111975_bib29
  article-title: Molecular inflammation: underpinnings of aging and age-related diseases
  publication-title: Ageing Res. Rev.
  doi: 10.1016/j.arr.2008.07.002
– volume: 257
  start-page: 43
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib20
  article-title: Topical captopril: a promising treatment for secondary lymphedema
  publication-title: Transl. Res.
  doi: 10.1016/j.trsl.2023.01.005
– volume: 11
  start-page: 160
  issue: 1
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib15
  article-title: Multifactorial mechanism of sarcopenia and sarcopenic obesity. Role of physical exercise, microbiota and myokines
  publication-title: Cells
  doi: 10.3390/cells11010160
– volume: 27
  start-page: 1837
  issue: 5
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib82
  article-title: The role of lymphangiogenesis in cardiovascular diseases and heart transplantation
  publication-title: Heart Fail. Rev.
  doi: 10.1007/s10741-021-10188-5
– volume: 30
  start-page: 325
  issue: 7
  year: 2009
  ident: 10.1016/j.mad.2024.111975_bib144
  article-title: Human innate immunosenescence: causes and consequences for immunity in old age
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2009.05.004
– volume: 100
  start-page: 697
  issue: 5
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib157
  article-title: Clinical perspectives on the age-related increase of immunosuppressive activity
  publication-title: J. Mol. Med.
  doi: 10.1007/s00109-022-02193-4
– volume: 15
  start-page: 2873
  issue: 13
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib159
  article-title: Glycocalyx-sodium interaction in vascular endothelium
  publication-title: Nutrients
  doi: 10.3390/nu15132873
– volume: 104
  start-page: 1302
  issue: 11
  year: 2009
  ident: 10.1016/j.mad.2024.111975_bib6
  article-title: Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.109.197830
– volume: 99
  start-page: 427
  issue: 1
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib103
  article-title: Sarcopenia: aging-related loss of muscle mass and function
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00061.2017
– volume: 17
  start-page: 7
  issue: 1
  year: 2016
  ident: 10.1016/j.mad.2024.111975_bib48
  article-title: Inflammaging decreases adaptive and innate immune responses in mice and humans
  publication-title: Biogerontology
  doi: 10.1007/s10522-015-9578-8
– volume: 18
  start-page: 1171
  issue: 3
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib178
  article-title: CD137L-macrophage induce lymphatic endothelial cells autophagy to promote lymphangiogenesis in renal fibrosis
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.66781
– volume: 27
  start-page: 955
  issue: 10
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib166
  article-title: Homeostatic maintenance of the lymphatic vasculature
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2021.07.003
– volume: 49
  start-page: 381
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib129
  article-title: Skeletal muscle as potential central link between sarcopenia and immune senescence
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2019.10.034
– volume: 5
  start-page: 99
  year: 2010
  ident: 10.1016/j.mad.2024.111975_bib31
  article-title: The senescence-associated secretory phenotype: the dark side of tumor suppression
  publication-title: Annu. Rev. Pathol.
  doi: 10.1146/annurev-pathol-121808-102144
– volume: 29
  start-page: 39
  issue: 1
  year: 2002
  ident: 10.1016/j.mad.2024.111975_bib140
  article-title: Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium
  publication-title: J. Rheumatol.
– volume: 8
  start-page: 200
  issue: 1
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib107
  article-title: Immunosenescence: molecular mechanisms and diseases
  publication-title: Signal Transduct. Target Ther.
  doi: 10.1038/s41392-023-01451-2
– volume: 89
  start-page: 285
  issue: 1
  year: 2017
  ident: 10.1016/j.mad.2024.111975_bib49
  article-title: Immune System Dysfunction in the Elderly
  publication-title: . Acad. Bras. Cienc.
  doi: 10.1590/0001-3765201720160487
– volume: 560
  start-page: 185
  issue: 7717
  year: 2018
  ident: 10.1016/j.mad.2024.111975_bib34
  article-title: Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease
  publication-title: Nature
  doi: 10.1038/s41586-018-0368-8
– volume: 26
  issue: 3
  year: 2016
  ident: 10.1016/j.mad.2024.111975_bib39
  article-title: Non-cell-autonomous regulation of cellular senescence in cancer
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2015.10.005
– volume: 35
  start-page: 12
  issue: 1
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib109
  article-title: Meta-hallmarks of aging and cancer
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2022.11.001
– volume: 10
  start-page: 1085
  issue: 9
  year: 1996
  ident: 10.1016/j.mad.2024.111975_bib28
  article-title: Lymphatic absorption of retinol in young, mature, and old rats: influence of dietary restriction
  publication-title: FASEB J.
  doi: 10.1096/fasebj.10.9.8801171
– volume: 369
  issue: 6500
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib148
  article-title: Biological functions of lymphatic vessels
  publication-title: Science
  doi: 10.1126/science.aax4063
– volume: 129
  start-page: 1292
  issue: 5
  year: 2009
  ident: 10.1016/j.mad.2024.111975_bib86
  article-title: Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2008.351
– volume: 273
  start-page: 70
  issue: 5271
  year: 1996
  ident: 10.1016/j.mad.2024.111975_bib123
  article-title: The aging immune system: primer and prospectus
  publication-title: Science
  doi: 10.1126/science.273.5271.70
– volume: 99
  start-page: 1047
  issue: 2
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib23
  article-title: Cellular senescence: aging, cancer, and injury
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00020.2018
– volume: 50
  start-page: 9911
  issue: 45
  year: 2011
  ident: 10.1016/j.mad.2024.111975_bib161
  article-title: Aging enhances the production of reactive oxygen species and bactericidal activity in peritoneal macrophages by upregulating classical activation pathways
  publication-title: Biochemistry
  doi: 10.1021/bi2011866
– volume: 11
  start-page: 457
  issue: 8
  year: 2015
  ident: 10.1016/j.mad.2024.111975_bib168
  article-title: Clearance systems in the brain-implications for Alzheimer disease
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/nrneurol.2015.119
– volume: 69
  start-page: 897
  issue: 6
  year: 2012
  ident: 10.1016/j.mad.2024.111975_bib80
  article-title: Macrophages are important mediators of either tumor- or inflammation-induced lymphangiogenesis
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-011-0848-6
– volume: 19
  start-page: 579
  issue: 9
  year: 2018
  ident: 10.1016/j.mad.2024.111975_bib59
  article-title: Autophagy as a promoter of longevity: insights from model organisms
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-018-0033-y
– volume: 1
  start-page: 634
  issue: 8
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib5
  article-title: Autophagy in healthy aging and disease
  publication-title: Nat. Aging
  doi: 10.1038/s43587-021-00098-4
– volume: 14
  start-page: 978
  issue: 1
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib184
  article-title: Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling
  publication-title: Nat. Commun
  doi: 10.1038/s41467-023-36562-5
– volume: 8
  start-page: 370
  issue: 3
  year: 2017
  ident: 10.1016/j.mad.2024.111975_bib74
  article-title: Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice
  publication-title: J. Cachex-.-. Sarcopenia Muscle
  doi: 10.1002/jcsm.12166
– volume: 64
  start-page: 620
  issue: 5
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib94
  article-title: Morphological and biochemical changes of lymphatic vessels in the soleus muscle of mice after hindlimb unloading
  publication-title: Muscle Nerve
  doi: 10.1002/mus.27402
– volume: 133
  start-page: 1019
  issue: 6
  year: 2008
  ident: 10.1016/j.mad.2024.111975_bib99
  article-title: Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
  publication-title: Cell
  doi: 10.1016/j.cell.2008.03.039
– volume: 371
  issue: 6528
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib143
  article-title: Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
  publication-title: Science
  doi: 10.1126/science.abc8059
– volume: 132
  issue: 9
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib52
  article-title: Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI140685
– volume: 128
  start-page: 1238
  issue: 4
  year: 2018
  ident: 10.1016/j.mad.2024.111975_bib64
  article-title: Mechanisms and functions of cellular senescence
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI95148
– volume: 35
  start-page: 785
  issue: 8
  year: 2018
  ident: 10.1016/j.mad.2024.111975_bib85
  article-title: Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis
  publication-title: Clin. Exp. Metastas-.-.
  doi: 10.1007/s10585-018-9940-8
– volume: 88
  start-page: 1021
  issue: 10
  year: 2010
  ident: 10.1016/j.mad.2024.111975_bib174
  article-title: Mitochondria and aging in the vascular system
  publication-title: J. Mol. Med. (Berl. )
  doi: 10.1007/s00109-010-0667-5
– volume: 2014
  year: 2014
  ident: 10.1016/j.mad.2024.111975_bib182
  article-title: The role of oxidative stress and inflammation in cardiovascular aging
  publication-title: Biomed. Res. Int.
  doi: 10.1155/2014/615312
– volume: 48
  start-page: 16
  issue: 1
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib32
  article-title: Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis
  publication-title: Age Ageing
  doi: 10.1093/ageing/afy169
– volume: 375
  start-page: 671
  issue: 6581
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib164
  article-title: Caloric restriction in humans reveals immunometabolic regulators of health span
  publication-title: Science
  doi: 10.1126/science.abg7292
– volume: 92
  start-page: 4337
  issue: 10
  year: 1995
  ident: 10.1016/j.mad.2024.111975_bib26
  article-title: Oxidative DNA damage and senescence of human diploid fibroblast cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.92.10.4337
– volume: 91
  issue: 16
  year: 2017
  ident: 10.1016/j.mad.2024.111975_bib120
  article-title: Role of autophagy in HIV-1 matrix protein p17-driven lymphangiogenesis
  publication-title: J. Virol.
  doi: 10.1128/JVI.00801-17
– volume: 14
  start-page: 2087
  issue: 13
  year: 2000
  ident: 10.1016/j.mad.2024.111975_bib145
  article-title: VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues
  publication-title: FASEB J.
  doi: 10.1096/fj.99-1049com
– volume: 20
  start-page: 12
  issue: 1
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib130
  article-title: Impact of aging on meningeal gene expression
  publication-title: Fluids Barriers CNS
  doi: 10.1186/s12987-023-00412-9
– volume: 212
  start-page: 991
  issue: 7
  year: 2015
  ident: 10.1016/j.mad.2024.111975_bib9
  article-title: A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20142290
– volume: 301
  start-page: H48
  issue: 1
  year: 2011
  ident: 10.1016/j.mad.2024.111975_bib37
  article-title: Determinants of valve gating in collecting lymphatic vessels from rat mesentery
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00133.2011
– volume: 219
  issue: 5
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib30
  article-title: Infection-induced lymphatic zippering restricts fluid transport and viral dissemination from skin
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20211830
– volume: 40
  start-page: 263
  issue: 2
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib183
  article-title: Impaired meningeal lymphatic vessel development worsens stroke outcome
  publication-title: J. Cereb. Blood Flow. Metab.
  doi: 10.1177/0271678X18822921
– volume: 13
  start-page: 19920
  issue: 15
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib21
  article-title: Cellular senescence in lymphoid organs and immunosenescence
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.203405
– volume: 177
  start-page: 3202
  issue: 6
  year: 2010
  ident: 10.1016/j.mad.2024.111975_bib10
  article-title: Blockade of transforming growth factor-beta1 accelerates lymphatic regeneration during wound repair
  publication-title: Am. J. Pathol.
  doi: 10.2353/ajpath.2010.100594
– volume: 34
  start-page: 1162
  issue: 6
  year: 2014
  ident: 10.1016/j.mad.2024.111975_bib175
  article-title: Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.114.302528
– volume: 13
  start-page: 2086
  issue: 12
  year: 2017
  ident: 10.1016/j.mad.2024.111975_bib151
  article-title: Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
  publication-title: Autophagy
  doi: 10.1080/15548627.2017.1380757
– volume: 214
  start-page: 3645
  issue: 12
  year: 2017
  ident: 10.1016/j.mad.2024.111975_bib7
  article-title: Development and plasticity of meningeal lymphatic vessels
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20170391
– volume: 153
  start-page: 1194
  issue: 6
  year: 2013
  ident: 10.1016/j.mad.2024.111975_bib108
  article-title: The hallmarks of aging
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.039
– volume: 69
  start-page: 1187
  issue: 6
  year: 2017
  ident: 10.1016/j.mad.2024.111975_bib17
  article-title: Brief report: treatment of tumor necrosis factor-transgenic mice with anti-tumor necrosis factor restores lymphatic contractions, repairs lymphatic vessels, and may increase monocyte/macrophage egress
  publication-title: Arthritis Rheuma
  doi: 10.1002/art.40047
– volume: 111
  start-page: 717
  issue: 5
  year: 2003
  ident: 10.1016/j.mad.2024.111975_bib188
  article-title: VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI15830
– volume: 41
  start-page: 2217
  issue: 4
  year: 2014
  ident: 10.1016/j.mad.2024.111975_bib83
  article-title: Rapamycin inhibition of CFA-induced lymphangiogenesis in PLN is independent of mast cells
  publication-title: Mol. Biol. Rep.
  doi: 10.1007/s11033-014-3073-1
– volume: 18
  start-page: 489
  issue: 4
  year: 2015
  ident: 10.1016/j.mad.2024.111975_bib87
  article-title: Decline of lymphatic vessel density and function in murine skin during aging
  publication-title: Angiogenesis
  doi: 10.1007/s10456-015-9479-0
– volume: 3
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib92
  article-title: Structural and functional changes in aged skin lymphatic vessels
  publication-title: Front. Aging
  doi: 10.3389/fragi.2022.864860
– volume: 87
  start-page: 427
  issue: 5
  year: 2008
  ident: 10.1016/j.mad.2024.111975_bib68
  article-title: Age-related changes in murine limbal lymphatic vessels and corneal lymphangiogenesis
  publication-title: Exp. Eye Res.
  doi: 10.1016/j.exer.2008.07.013
– volume: 18
  start-page: 965
  issue: 5
  year: 2017
  ident: 10.1016/j.mad.2024.111975_bib141
  article-title: Aged Lymphatic Vessels and Mast Cells in Perilymphatic Tissues
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms18050965
– volume: 72
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib93
  article-title: Autophagy and the hallmarks of aging
  publication-title: Ageing Res. Rev.
  doi: 10.1016/j.arr.2021.101468
– volume: 60
  start-page: 2666
  issue: 9
  year: 2009
  ident: 10.1016/j.mad.2024.111975_bib57
  article-title: Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.24764
– volume: 64
  start-page: 3737
  issue: 11
  year: 2004
  ident: 10.1016/j.mad.2024.111975_bib62
  article-title: Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-04-0088
– volume: 115
  start-page: 2316
  issue: 9
  year: 2005
  ident: 10.1016/j.mad.2024.111975_bib95
  article-title: The crucial role of macrophages in lymphangiogenesis
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI26354
– volume: 9
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib172
  article-title: Transforming growth factor-β in tumour development
  publication-title: Front. Mol. Biosci.
  doi: 10.3389/fmolb.2022.991612
– volume: 220
  issue: 7
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib156
  article-title: Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20221929
– volume: 14
  start-page: 877
  issue: 12
  year: 2013
  ident: 10.1016/j.mad.2024.111975_bib121
  article-title: Proinflammatory cytokines, aging, and age-related diseases
  publication-title: J. Am. Med. Dir. Assoc.
  doi: 10.1016/j.jamda.2013.05.009
– volume: 7
  year: 2016
  ident: 10.1016/j.mad.2024.111975_bib27
  article-title: Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
  publication-title: Nat. Commun.
– volume: 119
  issue: 17
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib162
  article-title: Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2121028119
– volume: 594
  start-page: 5749
  issue: 20
  year: 2016
  ident: 10.1016/j.mad.2024.111975_bib158
  article-title: Lymphatic pumping: mechanics, mechanisms and malfunction
  publication-title: J. Physiol.
  doi: 10.1113/JP272088
– volume: 123
  start-page: 613
  issue: 6
  year: 2011
  ident: 10.1016/j.mad.2024.111975_bib102
  article-title: Growth factor therapy and autologous lymph node transfer in lymphedema
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.110.965384
– volume: 20
  start-page: 77
  issue: 2
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib101
  article-title: The dynamic interplay between mast cells, aging/cellular senescence, and liver disease
  publication-title: Gene Expr.
  doi: 10.3727/105221620X15960509906371
– volume: 15
  issue: 5
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib190
  article-title: TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0232356
– volume: 10
  start-page: 293
  issue: 4
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib45
  article-title: Lymphatic senescence: current updates and perspectives
  publication-title: Biology
  doi: 10.3390/biology10040293
– volume: 13
  start-page: 203
  issue: 1
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib3
  article-title: Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-27887-0
– volume: 211
  start-page: 261
  year: 2018
  ident: 10.1016/j.mad.2024.111975_bib81
  article-title: Recent advances and new insights into muscular lymphangiogenesis in health and disease
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2018.09.043
– volume: 32
  start-page: 18
  issue: 1
  year: 2012
  ident: 10.1016/j.mad.2024.111975_bib115
  article-title: Advanced age impairs macrophage polarization
  publication-title: J. Interferon Cytokine Res.
  doi: 10.1089/jir.2011.0058
– volume: 37
  start-page: 389
  issue: 2-3
  year: 2002
  ident: 10.1016/j.mad.2024.111975_bib65
  article-title: Immunosenescence of macrophages: reduced MHC class II gene expression
  publication-title: Exp. Gerontol.
  doi: 10.1016/S0531-5565(01)00205-4
– volume: 170
  year: 2024
  ident: 10.1016/j.mad.2024.111975_bib135
  article-title: CCBE1 regulates the development and prevents the age-dependent regression of meningeal lymphatics
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2023.116032
– volume: 123
  start-page: 1571
  issue: 4
  year: 2013
  ident: 10.1016/j.mad.2024.111975_bib117
  article-title: Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI63685
– volume: 8
  start-page: 1434
  issue: 1
  year: 2017
  ident: 10.1016/j.mad.2024.111975_bib112
  article-title: Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01484-6
– volume: 7
  start-page: 1418
  issue: 11
  year: 2015
  ident: 10.1016/j.mad.2024.111975_bib133
  article-title: VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.201505731
– volume: 13
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib195
  article-title: A novel signature of aging-related genes associated with lymphatic metastasis for survival prediction in patients with bladder cancer
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2023.1140891
– volume: 128
  start-page: 2003
  issue: 12
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib155
  article-title: Advances in lymphedema
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.121.318307
– volume: 37
  start-page: 456
  issue: 5-6
  year: 1997
  ident: 10.1016/j.mad.2024.111975_bib138
  article-title: Lymphatic system of the pancreas
  publication-title: Microsc. Res. Tech.
  doi: 10.1002/(SICI)1097-0029(19970601)37:5/6<456::AID-JEMT9>3.0.CO;2-B
– volume: 28
  start-page: 97
  issue: 2
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib47
  article-title: Skin senescence: mechanisms and impact on whole-body aging
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2021.12.003
– volume: 148
  start-page: 1231
  issue: 16
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib98
  article-title: Lymphatic sphingosine-1-phosphate signaling aggravates lymphatic dysfunction and tissue inflammation
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.123.064181
– volume: 9
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib100
  article-title: Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
  publication-title: Front. Cell Dev. Biol.
  doi: 10.3389/fcell.2021.645593
– volume: 18
  start-page: 1166
  issue: 12
  year: 2011
  ident: 10.1016/j.mad.2024.111975_bib89
  article-title: Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle
  publication-title: Gene Ther.
  doi: 10.1038/gt.2011.66
– volume: 132
  start-page: 1203
  issue: 9
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib8
  article-title: Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.123.322136
– volume: 20
  start-page: 566
  issue: 9
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib77
  article-title: Lymphatic endothelial cells of the lymph node
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-020-0281-x
– volume: 7
  issue: 21
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib35
  article-title: Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abe4601
– volume: 577
  start-page: 689
  issue: 7792
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib163
  article-title: VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours
  publication-title: Nature
  doi: 10.1038/s41586-019-1912-x
– volume: 30
  start-page: 229
  issue: 3
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib71
  article-title: Meningeal lymphatic vessels regulate brain tumor drainage and immunity
  publication-title: Cell Res
  doi: 10.1038/s41422-020-0287-8
– volume: 103
  start-page: 85
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib105
  article-title: Drainage of senescent astrocytes from brain via meningeal lymphatic routes
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2022.04.005
– volume: 10
  start-page: 3148
  issue: 11
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib22
  article-title: Aging-related cellular, structural and functional changes in the lymph nodes: a significant component of immunosenescence? An overview
  publication-title: Cells
  doi: 10.3390/cells10113148
– volume: 20
  issue: 4
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib167
  article-title: Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages
  publication-title: EMBO Rep.
  doi: 10.15252/embr.201846927
– volume: 283
  start-page: 25
  issue: 1
  year: 2016
  ident: 10.1016/j.mad.2024.111975_bib114
  article-title: Vesicular trafficking mechanisms in endothelial cells as modulators of the tumor vasculature and targets of antiangiogenic therapies
  publication-title: FEBS J.
  doi: 10.1111/febs.13545
– volume: 17
  start-page: 1183
  issue: 9
  year: 2003
  ident: 10.1016/j.mad.2024.111975_bib33
  article-title: Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries
  publication-title: FASEB J.
  doi: 10.1096/fj.02-1049fje
– volume: 13
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib40
  article-title: Age-related alterations in macrophage distribution and function are associated with delayed cutaneous wound healing
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2022.943159
– volume: 11
  start-page: 6602
  issue: 16
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib160
  article-title: Pathophysiology of aged lymphatic vessels
  publication-title: Aging
  doi: 10.18632/aging.102213
– volume: 3
  start-page: 829
  issue: 7
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib38
  article-title: Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters
  publication-title: Nat. Aging
  doi: 10.1038/s43587-023-00442-w
– volume: 10
  start-page: 470
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib91
  article-title: Regulation of Immune Function by the Lymphatic System in Lymphedema
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.00470
– volume: 2
  start-page: 704
  issue: 8
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib54
  article-title: Age-associated suppression of exploratory activity during sickness is linked to meningeal lymphatic dysfunction and microglia activation
  publication-title: Nat. Aging
  doi: 10.1038/s43587-022-00268-y
– volume: 50
  start-page: 889
  issue: 5
  year: 2002
  ident: 10.1016/j.mad.2024.111975_bib78
  article-title: Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1046/j.1532-5415.2002.50216.x
– volume: 123
  start-page: 2803
  issue: 7
  year: 2013
  ident: 10.1016/j.mad.2024.111975_bib180
  article-title: Immune cells control skin lymphatic electrolyte homeostasis and blood pressure
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI60113
– volume: 10
  start-page: 1054
  issue: 5
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib173
  article-title: Manifestations of age on autophagy, mitophagy and lysosomes in skeletal muscle
  publication-title: Cells
  doi: 10.3390/cells10051054
– volume: 20
  start-page: 460
  issue: 3
  year: 2014
  ident: 10.1016/j.mad.2024.111975_bib146
  article-title: An overview of autophagy: morphology, mechanism, and regulation
  publication-title: Antioxid. Redox Signal
  doi: 10.1089/ars.2013.5371
– volume: 20
  start-page: 421
  issue: 7
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib66
  article-title: The proteostasis network and its decline in ageing
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-019-0101-y
– volume: 66
  start-page: 419
  issue: 5
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib76
  article-title: Lymphatic capillaries in aging
  publication-title: Gerontology
  doi: 10.1159/000508459
– volume: 64
  start-page: 279
  issue: 3
  year: 2004
  ident: 10.1016/j.mad.2024.111975_bib84
  article-title: Expression of VEGFR-3 and 5′-nase in regenerating lymphatic vessels of the cutaneous wound healing
  publication-title: Microsc. Res. Tech.
  doi: 10.1002/jemt.20082
– volume: 12
  start-page: 109
  issue: 1
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib193
  article-title: Lymphangiogenesis in renal fibrosis arises from macrophages via VEGF-C/VEGFR3-dependent autophagy and polarization
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-020-03385-x
– volume: 8
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib11
  article-title: Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2021.763930
– volume: 62
  start-page: 17
  issue: 13
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib176
  article-title: Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1+ macrophage infiltration
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.62.13.17
– volume: 3
  start-page: 23
  issue: 1
  year: 2003
  ident: 10.1016/j.mad.2024.111975_bib55
  article-title: Alternative activation of macrophages
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri978
– volume: 65
  start-page: 106
  issue: 2
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib13
  article-title: The glymphatic system and waste clearance with brain aging: a review
  publication-title: Gerontology
  doi: 10.1159/000490349
– volume: 10
  start-page: 229
  issue: 1
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib70
  article-title: Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-08163-0
– start-page: 724
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib185
  article-title: Signaling mechanisms underlying lymphatic vessel dysfunction in skin aging and possible anti-aging strategies
  publication-title: Biogerontology
– volume: 11
  start-page: 1234
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib142
  article-title: Emerging roles of mast cells in the regulation of lymphatic immuno-physiology
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.01234
– volume: 13
  start-page: 709
  issue: 4
  year: 2018
  ident: 10.1016/j.mad.2024.111975_bib179
  article-title: Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease
  publication-title: Neural Regen. Res.
  doi: 10.4103/1673-5374.230299
– volume: 14
  start-page: 582
  issue: 4
  year: 2015
  ident: 10.1016/j.mad.2024.111975_bib197
  article-title: Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance
  publication-title: Aging Cell
  doi: 10.1111/acel.12330
– volume: 111
  start-page: 4571
  issue: 9
  year: 2008
  ident: 10.1016/j.mad.2024.111975_bib137
  article-title: Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis.
  publication-title: Blood
  doi: 10.1182/blood-2007-10-120337
– year: 2024
  ident: 10.1016/j.mad.2024.111975_bib131
  article-title: LECs regulate neutrophil clearance through IL-17RC/CMTM4/NF-kappaB axis at sites of inflammation or infection.
  publication-title: Mucosal Immunol.
  doi: 10.1016/j.mucimm.2024.05.003
– volume: 124
  start-page: 3863
  issue: 9
  year: 2014
  ident: 10.1016/j.mad.2024.111975_bib36
  article-title: VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI72189
– volume: 572
  start-page: 62
  issue: 7767
  year: 2019
  ident: 10.1016/j.mad.2024.111975_bib1
  article-title: Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
  publication-title: Nature
  doi: 10.1038/s41586-019-1419-5
– volume: 620
  start-page: 374
  issue: 7973
  year: 2023
  ident: 10.1016/j.mad.2024.111975_bib56
  article-title: cGAS-STING drives ageing-related inflammation and neurodegeneration
  publication-title: Nature
  doi: 10.1038/s41586-023-06373-1
– volume: 29
  start-page: 990
  issue: 6
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib113
  article-title: Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2022.04.017
– volume: 13
  start-page: 153
  issue: 3
  year: 2014
  ident: 10.1016/j.mad.2024.111975_bib196
  article-title: Inflammaging in skin and other tissues - the roles of complement system and macrophage
  publication-title: Inflamm. Allergy Drug Targets
  doi: 10.2174/1871528113666140522112003
– volume: 11
  start-page: 35
  issue: 1
  year: 2013
  ident: 10.1016/j.mad.2024.111975_bib19
  article-title: Lymphatic muscle cells in rat mesenteric lymphatic vessels of various ages
  publication-title: Lymphat. Res. Biol.
  doi: 10.1089/lrb.2012.0025
– volume: 11
  start-page: 1249
  issue: 7
  year: 2022
  ident: 10.1016/j.mad.2024.111975_bib14
  article-title: Early Protective Role of Inflammation in Cardiac Remodeling and Heart Failure: Focus on TNFα and Resident Macrophages
  publication-title: Cells
  doi: 10.3390/cells11071249
– volume: 145
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib171
  article-title: Aging of the immune system and impaired muscle regeneration: a failure of immunomodulation of adult myogenesis
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2020.111200
– volume: 128
  start-page: 87
  issue: 1
  year: 2020
  ident: 10.1016/j.mad.2024.111975_bib104
  article-title: Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation
  publication-title: J. Appl. Physiol. (1985)
  doi: 10.1152/japplphysiol.00495.2019
– volume: 10
  start-page: 5129
  issue: 21
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib189
  article-title: Lymphaticovenous anastomosis for age-related lymphedema
  publication-title: J. Clin. Med.
  doi: 10.3390/jcm10215129
– volume: 92
  start-page: 1098
  issue: 10
  year: 2003
  ident: 10.1016/j.mad.2024.111975_bib154
  article-title: VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000073584.46059.E3
– volume: 141
  start-page: 985
  issue: 4S
  year: 2021
  ident: 10.1016/j.mad.2024.111975_bib181
  article-title: Connective tissue and fibroblast senescence in skin aging
  publication-title: J. Invest. Dermatol.
  doi: 10.1016/j.jid.2020.11.010
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Snippet Lymphatic aging represented by cellular and functional changes, is involved in increased geriatric disorders, but the intersection between aging and lymphatic...
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StartPage 111975
SubjectTerms Aging
Lymphangiogenesis
Lymphatic-associated diseases
Macrophage
Senescence-associated secretory phenotype (SASP)
VEGF-C/VEGFR-3
Title The emerging importance of lymphangiogenesis in aging and aging-associated diseases
URI https://dx.doi.org/10.1016/j.mad.2024.111975
https://www.ncbi.nlm.nih.gov/pubmed/39089499
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