GDF15 promotes EMT and metastasis in colorectal cancer

Metastasis is the major cause of cancer deaths, and the epithelial-mesenchymal transition (EMT) has been considered to be a fundamental event in cancer metastasis. However, the role of growth differentiation factor 15 (GDF15) in colorectal cancer (CRC) metastasis and EMT remains poorly understood. H...

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Bibliographic Details
Published in:	Oncotarget Vol. 7; no. 1; p. 860
Main Authors:	Li, Chen, Wang, Jingyu, Kong, Jianlu, Tang, Jinlong, Wu, Yihua, Xu, Enping, Zhang, Honghe, Lai, Maode
Format:	Journal Article
Language:	English
Published:	United States 05.01.2016
Subjects:	Animals Cell Line, Tumor Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Epithelial-Mesenchymal Transition - genetics Female Gene Expression Regulation, Neoplastic Growth Differentiation Factor 15 - blood Growth Differentiation Factor 15 - genetics Growth Differentiation Factor 15 - metabolism HEK293 Cells HT29 Cells Humans Immunoblotting Immunohistochemistry Male Mice, Inbred NOD Mice, SCID Middle Aged Neoplasm Metastasis Proportional Hazards Models Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Reverse Transcriptase Polymerase Chain Reaction - statistics & numerical data RNA Interference Smad2 Protein - genetics Smad2 Protein - metabolism Smad3 Protein - genetics Smad3 Protein - metabolism Survival Analysis Transplantation, Heterologous colorectal cancer GDF15 metastasis EMT
ISSN:	1949-2553, 1949-2553
Online Access:	Get more information
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