GDF15 promotes EMT and metastasis in colorectal cancer
Metastasis is the major cause of cancer deaths, and the epithelial-mesenchymal transition (EMT) has been considered to be a fundamental event in cancer metastasis. However, the role of growth differentiation factor 15 (GDF15) in colorectal cancer (CRC) metastasis and EMT remains poorly understood. H...
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| Veröffentlicht in: | Oncotarget Jg. 7; H. 1; S. 860 |
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| Abstract | Metastasis is the major cause of cancer deaths, and the epithelial-mesenchymal transition (EMT) has been considered to be a fundamental event in cancer metastasis. However, the role of growth differentiation factor 15 (GDF15) in colorectal cancer (CRC) metastasis and EMT remains poorly understood. Here, we showed that GDF15 promoted CRC cell metastasis both in vitro and in vivo. In addition, the EMT process was enhanced by GDF15 through binding to TGF-β receptor to activate Smad2 and Smad3 pathways. Clinical data showed GDF15 level in tumor tissues, and the serum was significantly increased, in which high GDF15 level correlated with a reduced overall survival in CRC. Thus, GDF15 may promote colorectal cancer metastasis through activating EMT. Promisingly, GDF15 could be considered as a novel prognostic marker for CRC in the clinic. |
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| AbstractList | Metastasis is the major cause of cancer deaths, and the epithelial-mesenchymal transition (EMT) has been considered to be a fundamental event in cancer metastasis. However, the role of growth differentiation factor 15 (GDF15) in colorectal cancer (CRC) metastasis and EMT remains poorly understood. Here, we showed that GDF15 promoted CRC cell metastasis both in vitro and in vivo. In addition, the EMT process was enhanced by GDF15 through binding to TGF-β receptor to activate Smad2 and Smad3 pathways. Clinical data showed GDF15 level in tumor tissues, and the serum was significantly increased, in which high GDF15 level correlated with a reduced overall survival in CRC. Thus, GDF15 may promote colorectal cancer metastasis through activating EMT. Promisingly, GDF15 could be considered as a novel prognostic marker for CRC in the clinic.Metastasis is the major cause of cancer deaths, and the epithelial-mesenchymal transition (EMT) has been considered to be a fundamental event in cancer metastasis. However, the role of growth differentiation factor 15 (GDF15) in colorectal cancer (CRC) metastasis and EMT remains poorly understood. Here, we showed that GDF15 promoted CRC cell metastasis both in vitro and in vivo. In addition, the EMT process was enhanced by GDF15 through binding to TGF-β receptor to activate Smad2 and Smad3 pathways. Clinical data showed GDF15 level in tumor tissues, and the serum was significantly increased, in which high GDF15 level correlated with a reduced overall survival in CRC. Thus, GDF15 may promote colorectal cancer metastasis through activating EMT. Promisingly, GDF15 could be considered as a novel prognostic marker for CRC in the clinic. Metastasis is the major cause of cancer deaths, and the epithelial-mesenchymal transition (EMT) has been considered to be a fundamental event in cancer metastasis. However, the role of growth differentiation factor 15 (GDF15) in colorectal cancer (CRC) metastasis and EMT remains poorly understood. Here, we showed that GDF15 promoted CRC cell metastasis both in vitro and in vivo. In addition, the EMT process was enhanced by GDF15 through binding to TGF-β receptor to activate Smad2 and Smad3 pathways. Clinical data showed GDF15 level in tumor tissues, and the serum was significantly increased, in which high GDF15 level correlated with a reduced overall survival in CRC. Thus, GDF15 may promote colorectal cancer metastasis through activating EMT. Promisingly, GDF15 could be considered as a novel prognostic marker for CRC in the clinic. |
| Author | Li, Chen Wang, Jingyu Tang, Jinlong Kong, Jianlu Lai, Maode Wu, Yihua Xu, Enping Zhang, Honghe |
| Author_xml | – sequence: 1 givenname: Chen surname: Li fullname: Li, Chen organization: Key Laboratory of Disease Proteomics of Zhejiang Province, Zhejiang, PR China – sequence: 2 givenname: Jingyu surname: Wang fullname: Wang, Jingyu organization: Key Constructing Discipline by Zhejiang Province and Jiaxing City, Zhejiang, PR China – sequence: 3 givenname: Jianlu surname: Kong fullname: Kong, Jianlu organization: Key Laboratory of Disease Proteomics of Zhejiang Province, Zhejiang, PR China – sequence: 4 givenname: Jinlong surname: Tang fullname: Tang, Jinlong organization: Department of Pathology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, PR China – sequence: 5 givenname: Yihua surname: Wu fullname: Wu, Yihua organization: Department of Pathology, School of Medicine, Zhejiang University, Zhejiang, PR China – sequence: 6 givenname: Enping surname: Xu fullname: Xu, Enping organization: Key Laboratory of Disease Proteomics of Zhejiang Province, Zhejiang, PR China – sequence: 7 givenname: Honghe surname: Zhang fullname: Zhang, Honghe organization: Key Laboratory of Disease Proteomics of Zhejiang Province, Zhejiang, PR China – sequence: 8 givenname: Maode surname: Lai fullname: Lai, Maode organization: Key Laboratory of Disease Proteomics of Zhejiang Province, Zhejiang, PR China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26497212$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Cell Line, Tumor Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Epithelial-Mesenchymal Transition - genetics Female Gene Expression Regulation, Neoplastic Growth Differentiation Factor 15 - blood Growth Differentiation Factor 15 - genetics Growth Differentiation Factor 15 - metabolism HEK293 Cells HT29 Cells Humans Immunoblotting Immunohistochemistry Male Mice, Inbred NOD Mice, SCID Middle Aged Neoplasm Metastasis Proportional Hazards Models Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Reverse Transcriptase Polymerase Chain Reaction - statistics & numerical data RNA Interference Smad2 Protein - genetics Smad2 Protein - metabolism Smad3 Protein - genetics Smad3 Protein - metabolism Survival Analysis Transplantation, Heterologous |
| Title | GDF15 promotes EMT and metastasis in colorectal cancer |
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