Clinical performance evaluation of an HIV Duo assay: From HIV screening to acute and non-acute HIV infection detection
•The Elecsys® HIV Duo assay has demonstrated a high specificity of 99.91 % (95 % CI: 99.89 %, 99.93 %) and a high PPV of 0.8516 (95 % CI: 0.8225, 0.8776), indicating that the assay is suitable for primary HIV screening in China.•The median (IQR) of the numeric cut-off index (COI) ratios of the HIV D...
Gespeichert in:
| Veröffentlicht in: | Clinica chimica acta Jg. 565; S. 119949 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Netherlands
Elsevier B.V
15.01.2025
|
| Schlagworte: | |
| ISSN: | 0009-8981, 1873-3492, 1873-3492 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | •The Elecsys® HIV Duo assay has demonstrated a high specificity of 99.91 % (95 % CI: 99.89 %, 99.93 %) and a high PPV of 0.8516 (95 % CI: 0.8225, 0.8776), indicating that the assay is suitable for primary HIV screening in China.•The median (IQR) of the numeric cut-off index (COI) ratios of the HIV Duo antibody (Ab) and antigen (Ag) results significantly differed among the subgroups of diagnosed HIV patients: Ag + Ab-, Ag-Ab+, and Ag + Ab+ (all P<0.05).•The Elecsys® HIV Duo assay can identify acute HIV patients with Western blot (WB) −/not able to define (ND) results by providing Ag + HIV Duo result. Therefore, integrating the assay into a novel laboratory HIV testing algorithm has the potential to enable early detection of acute HIV infections and facilitating treatment initiation.
Evaluating the clinical performance of Elecsys HIV Duo assay for primary human immunodeficiency virus (HIV) screening and acute HIV infection detection.
This study was conducted from April 2022 to April 2023 and involved two distinct populations. For the HIV screening population, three HIV Duo results [HIV Duo, HIV antigen (Ag), and HIV antibody (Ab)] in primary screening were obtained (January 2021 to June 2021). In the diagnosed HIV population, retrospective samples from November 2016 to March 2023 were measured.
The HIV screening population included 111,383 samples from a real-world screening program. The assay demonstrated a specificity of 99.91 % (95 % CI: 99.89 %, 99.93 %) and a PPV of 0.8516 (95 % CI: 0.8225, 0.8776). Regarding the diagnosed HIV population, 836 HIV patients were enrolled, including 14 acute HIV infectious patients with only HIV Ag + and a Western Blot (WB) confirmation rate of 0 %. The median (IQR) of the numeric cut-off index (COI) ratios of HIV Duo Ab and Ag significantly differed among the Ag + Ab-, Ag-Ab+, and Ag + Ab + subgroups.
The Elecsys HIV Duo assay is suitable for primary HIV screening and can be integrated into a novel laboratory HIV testing algorithm to improve acute HIV detection in Chinese clinical practice.
Abbreviations: HIV, Human immunodeficiency virus; AIDS, acquired immunodeficiency syndrome; Ag, antigen; Ab, antibody; WB, Western Blot; COI, numeric cut-off index; CI, confidence interval; NAT, nucleic acid tests; EDC, electronic data capture systems; CDC, Chinese Centers for Disease Control and Prevention; IQR, interquartile range; PPV, positive predictive value; HCV, hepatitis C virus; HBV, hepatitis B virus; CI, confidence interval; ND, not able to define; F, female; M, male; |
|---|---|
| AbstractList | Evaluating the clinical performance of Elecsys HIV Duo assay for primary human immunodeficiency virus (HIV) screening and acute HIV infection detection.BACKGROUNDEvaluating the clinical performance of Elecsys HIV Duo assay for primary human immunodeficiency virus (HIV) screening and acute HIV infection detection.This study was conducted from April 2022 to April 2023 and involved two distinct populations. For the HIV screening population, three HIV Duo results [HIV Duo, HIV antigen (Ag), and HIV antibody (Ab)] in primary screening were obtained (January 2021 to June 2021). In the diagnosed HIV population, retrospective samples from November 2016 to March 2023 were measured.METHODSThis study was conducted from April 2022 to April 2023 and involved two distinct populations. For the HIV screening population, three HIV Duo results [HIV Duo, HIV antigen (Ag), and HIV antibody (Ab)] in primary screening were obtained (January 2021 to June 2021). In the diagnosed HIV population, retrospective samples from November 2016 to March 2023 were measured.The HIV screening population included 111,383 samples from a real-world screening program. The assay demonstrated a specificity of 99.91 % (95 % CI: 99.89 %, 99.93 %) and a PPV of 0.8516 (95 % CI: 0.8225, 0.8776). Regarding the diagnosed HIV population, 836 HIV patients were enrolled, including 14 acute HIV infectious patients with only HIV Ag + and a Western Blot (WB) confirmation rate of 0 %. The median (IQR) of the numeric cut-off index (COI) ratios of HIV Duo Ab and Ag significantly differed among the Ag + Ab-, Ag-Ab+, and Ag + Ab + subgroups.RESULTSThe HIV screening population included 111,383 samples from a real-world screening program. The assay demonstrated a specificity of 99.91 % (95 % CI: 99.89 %, 99.93 %) and a PPV of 0.8516 (95 % CI: 0.8225, 0.8776). Regarding the diagnosed HIV population, 836 HIV patients were enrolled, including 14 acute HIV infectious patients with only HIV Ag + and a Western Blot (WB) confirmation rate of 0 %. The median (IQR) of the numeric cut-off index (COI) ratios of HIV Duo Ab and Ag significantly differed among the Ag + Ab-, Ag-Ab+, and Ag + Ab + subgroups.The Elecsys HIV Duo assay is suitable for primary HIV screening and can be integrated into a novel laboratory HIV testing algorithm to improve acute HIV detection in Chinese clinical practice.CONCLUSIONThe Elecsys HIV Duo assay is suitable for primary HIV screening and can be integrated into a novel laboratory HIV testing algorithm to improve acute HIV detection in Chinese clinical practice.HIV, Human immunodeficiency virus; AIDS, acquired immunodeficiency syndrome; Ag, antigen; Ab, antibody; WB, Western Blot; COI, numeric cut-off index; CI, confidence interval; NAT, nucleic acid tests; EDC, electronic data capture systems; CDC, Chinese Centers for Disease Control and Prevention; IQR, interquartile range; PPV, positive predictive value; HCV, hepatitis C virus; HBV, hepatitis B virus; CI, confidence interval; ND, not able to define; F, female; M, male.ABBREVIATIONSHIV, Human immunodeficiency virus; AIDS, acquired immunodeficiency syndrome; Ag, antigen; Ab, antibody; WB, Western Blot; COI, numeric cut-off index; CI, confidence interval; NAT, nucleic acid tests; EDC, electronic data capture systems; CDC, Chinese Centers for Disease Control and Prevention; IQR, interquartile range; PPV, positive predictive value; HCV, hepatitis C virus; HBV, hepatitis B virus; CI, confidence interval; ND, not able to define; F, female; M, male. Evaluating the clinical performance of Elecsys HIV Duo assay for primary human immunodeficiency virus (HIV) screening and acute HIV infection detection. This study was conducted from April 2022 to April 2023 and involved two distinct populations. For the HIV screening population, three HIV Duo results [HIV Duo, HIV antigen (Ag), and HIV antibody (Ab)] in primary screening were obtained (January 2021 to June 2021). In the diagnosed HIV population, retrospective samples from November 2016 to March 2023 were measured. The HIV screening population included 111,383 samples from a real-world screening program. The assay demonstrated a specificity of 99.91 % (95 % CI: 99.89 %, 99.93 %) and a PPV of 0.8516 (95 % CI: 0.8225, 0.8776). Regarding the diagnosed HIV population, 836 HIV patients were enrolled, including 14 acute HIV infectious patients with only HIV Ag + and a Western Blot (WB) confirmation rate of 0 %. The median (IQR) of the numeric cut-off index (COI) ratios of HIV Duo Ab and Ag significantly differed among the Ag + Ab-, Ag-Ab+, and Ag + Ab + subgroups. The Elecsys HIV Duo assay is suitable for primary HIV screening and can be integrated into a novel laboratory HIV testing algorithm to improve acute HIV detection in Chinese clinical practice. HIV, Human immunodeficiency virus; AIDS, acquired immunodeficiency syndrome; Ag, antigen; Ab, antibody; WB, Western Blot; COI, numeric cut-off index; CI, confidence interval; NAT, nucleic acid tests; EDC, electronic data capture systems; CDC, Chinese Centers for Disease Control and Prevention; IQR, interquartile range; PPV, positive predictive value; HCV, hepatitis C virus; HBV, hepatitis B virus; CI, confidence interval; ND, not able to define; F, female; M, male. •The Elecsys® HIV Duo assay has demonstrated a high specificity of 99.91 % (95 % CI: 99.89 %, 99.93 %) and a high PPV of 0.8516 (95 % CI: 0.8225, 0.8776), indicating that the assay is suitable for primary HIV screening in China.•The median (IQR) of the numeric cut-off index (COI) ratios of the HIV Duo antibody (Ab) and antigen (Ag) results significantly differed among the subgroups of diagnosed HIV patients: Ag + Ab-, Ag-Ab+, and Ag + Ab+ (all P<0.05).•The Elecsys® HIV Duo assay can identify acute HIV patients with Western blot (WB) −/not able to define (ND) results by providing Ag + HIV Duo result. Therefore, integrating the assay into a novel laboratory HIV testing algorithm has the potential to enable early detection of acute HIV infections and facilitating treatment initiation. Evaluating the clinical performance of Elecsys HIV Duo assay for primary human immunodeficiency virus (HIV) screening and acute HIV infection detection. This study was conducted from April 2022 to April 2023 and involved two distinct populations. For the HIV screening population, three HIV Duo results [HIV Duo, HIV antigen (Ag), and HIV antibody (Ab)] in primary screening were obtained (January 2021 to June 2021). In the diagnosed HIV population, retrospective samples from November 2016 to March 2023 were measured. The HIV screening population included 111,383 samples from a real-world screening program. The assay demonstrated a specificity of 99.91 % (95 % CI: 99.89 %, 99.93 %) and a PPV of 0.8516 (95 % CI: 0.8225, 0.8776). Regarding the diagnosed HIV population, 836 HIV patients were enrolled, including 14 acute HIV infectious patients with only HIV Ag + and a Western Blot (WB) confirmation rate of 0 %. The median (IQR) of the numeric cut-off index (COI) ratios of HIV Duo Ab and Ag significantly differed among the Ag + Ab-, Ag-Ab+, and Ag + Ab + subgroups. The Elecsys HIV Duo assay is suitable for primary HIV screening and can be integrated into a novel laboratory HIV testing algorithm to improve acute HIV detection in Chinese clinical practice. Abbreviations: HIV, Human immunodeficiency virus; AIDS, acquired immunodeficiency syndrome; Ag, antigen; Ab, antibody; WB, Western Blot; COI, numeric cut-off index; CI, confidence interval; NAT, nucleic acid tests; EDC, electronic data capture systems; CDC, Chinese Centers for Disease Control and Prevention; IQR, interquartile range; PPV, positive predictive value; HCV, hepatitis C virus; HBV, hepatitis B virus; CI, confidence interval; ND, not able to define; F, female; M, male; |
| ArticleNumber | 119949 |
| Author | Chen, An-Jou Li, Dongdong Lou, Jinli Yuan, Yulin Wu, Chongyang Tao, Chuanmin Wu, Rongcai Liu, Xin Feng, Xia Lu, Qiuwei |
| Author_xml | – sequence: 1 givenname: Xin surname: Liu fullname: Liu, Xin organization: Beijing You’An Hospital, Capital Medical University, Beijing, China – sequence: 2 givenname: Chongyang surname: Wu fullname: Wu, Chongyang organization: West China Hospital, Sichuan University, Chengdu, China – sequence: 3 givenname: Yulin surname: Yuan fullname: Yuan, Yulin organization: The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China – sequence: 4 givenname: Dongdong surname: Li fullname: Li, Dongdong organization: West China Hospital, Sichuan University, Chengdu, China – sequence: 5 givenname: Jinli surname: Lou fullname: Lou, Jinli organization: Beijing You’An Hospital, Capital Medical University, Beijing, China – sequence: 6 givenname: Xia surname: Feng fullname: Feng, Xia organization: Beijing You’An Hospital, Capital Medical University, Beijing, China – sequence: 7 givenname: Qiuwei surname: Lu fullname: Lu, Qiuwei organization: The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China – sequence: 8 givenname: Rongcai surname: Wu fullname: Wu, Rongcai organization: The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China – sequence: 9 givenname: An-Jou surname: Chen fullname: Chen, An-Jou organization: Roche Diagnostics (Shanghai) Ltd., Shanghai, China – sequence: 10 givenname: Chuanmin surname: Tao fullname: Tao, Chuanmin email: taocm@scu.edu.cn organization: West China Hospital, Sichuan University, Chengdu, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39241902$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kUtv3CAUhVGVqJmk_QHdRCyz8ZRXsUlW0eQpRcqm7RYx19cVIxumYI-Ufx9mnHTRRTbAhe9cXc45JUchBiTkG2dLzrj-vlkCuKVgQi05N0aZT2TBm1pWUhlxRBaMMVM1puEn5DTnTSkV0_wzOZFGKG6YWJDdqvfBg-vpFlMX0-ACIMWd6yc3-hho7KgL9OHxN72ZInU5u5dLepficLjLkBCDD3_oWB5hGrHQLS1zVnO1h3zoEA7NWhzn0xdy3Lk-49e3_Yz8urv9uXqonp7vH1fXTxVIo8dKK2gAuDTSYS2EY7pW4IRYt7wtf1MKdLtmvKzKdEIgunXXOc210voH1EqekYu57zbFvxPm0Q4-A_a9CxinbGXxsTayYU1Bz9_QaT1ga7fJDy692HevCsBnAFLMOWH3D-HM7vOwG1vysPs87JxH0dT_acCPB2PH5Hz_ofJqVmKxZ-cx2QweSzitT8VD20b_gfoV1eujtQ |
| CitedBy_id | crossref_primary_10_1016_j_microc_2025_113797 |
| Cites_doi | 10.7326/0003-4819-113-11-872 10.1016/j.jcv.2013.08.019 10.1016/j.jcv.2018.11.005 10.1097/CM9.0000000000001842 10.1097/QAI.0b013e31829871e0 10.3389/fcimb.2022.877643 10.1002/jmv.25845 10.1086/655651 10.1136/sextrans-2014-051574 10.1128/CVI.00053-16 10.1136/sextrans-2020-054706 10.1016/j.jcv.2019.04.002 10.1097/OLQ.0b013e318195c302 10.1038/35035103 10.1016/j.jcv.2017.06.006 10.4269/ajtmh.19-0144 10.1016/j.idcr.2021.e01168 10.1177/0956462414531244 10.1016/j.bsheal.2019.12.001 10.1097/00002030-200205240-00005 10.1093/jalm/jfab069 10.1086/386333 10.46234/ccdcw2021.190 10.1097/QAD.0b013e3281532c82 10.1056/NEJMra1011874 10.1097/QAI.0b013e31802ea4c6 10.1097/OLQ.0000000000001124 10.1001/jama.2020.17025 10.1056/NEJMoa1506816 10.1128/JCM.03030-20 10.1056/NEJMoa1508952 10.3389/fpubh.2022.1002342 10.1016/j.jcv.2013.08.031 10.1093/cid/civ398 10.1186/s12985-020-01404-z 10.1007/s10461-009-9590-6 10.1002/jmv.21441 |
| ContentType | Journal Article |
| Copyright | 2024 The Authors Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2024 The Authors – notice: Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.cca.2024.119949 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry |
| EISSN | 1873-3492 |
| ExternalDocumentID | 39241902 10_1016_j_cca_2024_119949 S0009898124022022 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 29B 4.4 457 4G. 5GY 5VS 6I. 6J9 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFTH AAIKJ AAKOC AALRI AAOAW AAQFI AAXKI AAXUO ABBQC ABFRF ABGSF ABJNI ABMAC ABMZM ABUDA ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFJKZ AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJOXV AJRQY AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W K-O KOM L7B LX3 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG RNS ROL RPZ SDF SDG SDP SES SEW SPCBC SSH SSU SSZ T5K WH7 ~02 ~G- .55 .GJ 53G 9DU AAQXK AATTM AAYWO AAYXX ABDPE ABFNM ABWVN ABXDB ACIEU ACLOT ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFPUW AGQPQ AGRDE AHHHB AIGII AIIUN AKBMS AKYEP ANKPU APXCP ASPBG AVWKF AZFZN CITATION EFKBS EFLBG EJD FEDTE FGOYB G-2 HLW HVGLF HZ~ J5H R2- SBG WUQ X7M XPP ZGI ~HD CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c396t-64c8cc1393ae722a0674ca22bd1d00944c6db01c6d49f22eeabffa6164665c743 |
| ISICitedReferencesCount | 2 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001310905800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0009-8981 1873-3492 |
| IngestDate | Sat Sep 27 17:18:07 EDT 2025 Wed Feb 19 02:02:58 EST 2025 Sat Nov 29 08:10:00 EST 2025 Tue Nov 18 21:52:56 EST 2025 Sat Nov 23 15:54:20 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Diagnostic testing algorithm P24 antigen HIV screening Acute HIV infection HIV Duo |
| Language | English |
| License | This is an open access article under the CC BY license. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c396t-64c8cc1393ae722a0674ca22bd1d00944c6db01c6d49f22eeabffa6164665c743 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://dx.doi.org/10.1016/j.cca.2024.119949 |
| PMID | 39241902 |
| PQID | 3101793808 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_3101793808 pubmed_primary_39241902 crossref_primary_10_1016_j_cca_2024_119949 crossref_citationtrail_10_1016_j_cca_2024_119949 elsevier_sciencedirect_doi_10_1016_j_cca_2024_119949 |
| PublicationCentury | 2000 |
| PublicationDate | 2025-01-15 |
| PublicationDateYYYYMMDD | 2025-01-15 |
| PublicationDate_xml | – month: 01 year: 2025 text: 2025-01-15 day: 15 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Clinica chimica acta |
| PublicationTitleAlternate | Clin Chim Acta |
| PublicationYear | 2025 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Consolidated Guidelines on HIV Prevention (b0030) 2021 T. Goodhue, A. Kazianis, B.G. Werner, T. Stiles, B.P. Callis, H. Dawn Fukuda, K. Cranston, 4th generation HIV screening in Massachusetts: a partnership between laboratory and program., J. Clin. Virol. 58 Suppl 1 (2013) e13-8. https://doi.org/10.1016/j.jcv.2013.08.019. Qiu, Liu, Jiang, Nkengasong, Xing, Pei, Parekh (b0165) 2009; 81 Livant, Heaps, Kelly, Maharaj, Samsunder, Nhlangulela, Karugaba, Panchia, Marrazzo, Chirenje, Parikh (b0075) 2017; 94 E.M. Lackritz, Prevention of HIV transmission by blood transfusion in the developing world: achievements and continuing challenges, AIDS. 12 Suppl A (1998) S81-6. Yu, Yu, Li, Liu, Wang, Deng (b0170) 2020; 17 Palacios, Jiménez-Oñate, Aguilar, Galindo, Rivas, Ocampo, Berenguer, Arranz, Ríos, Knobel, Moreno, Ena, Santos (b0185) 2007; 44 Pham, Nguyen, Nguyen, Le, Tran, Nguyen, Wilson, Zhang (b0200) 2015; 91 Adetunji, Adewumi, Michael, Fayemiwo, Ogunniyi, Taiwo (b0040) 2019; 101 de Lind, van Wijngaarden, Brown, Girault, van Sarkar, Griensven (b0195) 2009; 36 Scott, Wu (b0020) 2019; 1 Pitasi, Patel, Wesolowski, Masciotra, Luo, Owen, Delaney (b0080) 2020; 47 Peng, He, Zheng, Zou, Jiang, Su, Chen (b0160) 2021; 3 Cohen, Gay, Busch, Hecht (b0035) 2010; 202 Saag, Gandhi, Hoy, Landovitz, Thompson, Sax, Smith, Benson, Buchbinder, Del Rio, Eron, Fätkenheuer, Günthard, Molina, Jacobsen, Volberding (b0100) 2020; 324 Hecht, Busch, Rawal, Webb, Rosenberg, Swanson, Chesney, Anderson, Levy, Kahn (b0130) 2002; 16 Pilcher, Joaki, Hoffman, Martinson, Mapanje, Stewart, Powers, Galvin, Chilongozi, Gama, Price, Fiscus, Cohen (b0115) 2007; 21 Gökengin, Geretti, Begovac, Palfreeman, Stevanovic, Tarasenko, Radcliffe (b0155) 2014; 25 Wu, Zhu, Sun, Yue, Zheng, Fu, Gong (b0190) 2022; 10 Krasowski, Wier, Smith, Riedel, Lauseker-Hao, Kelner, Wang (b0055) 2021; 6 Alexander (b0090) 2016; 23 Cohen, Shaw, McMichael, Haynes (b0135) 2011; 364 Zhang, Ma, Zhao, Wang, Pu, Han (b0065) 2020; 92 Smith, Rutstein, Powers, Fidler, Miller, Eron, Cohen (b0140) 2013; 63 Rosenberg, Altfeld, Poon, Phillips, Wilkes, Eldridge, Robbins, D’Aquila, Goulder, Walker (b0145) 2000; 407 Parker, Carrasco, Chen (b0105) 2019; 116 Yang, Yang, Shi, Tao (b0070) 2022; 12 Medina-De la Garza, de Castro-Corona, Salinas-Carmona (b0110) 2021; 25 B.M. Branson, S.M. Owen, L.G. Wesolowski, B. Bennett, B.G. Werner, K.E. Wroblewski, M.A. Pentella, Laboratory testing for the diagnosis of HIV infection : updated recommendations (2014), (n.d.). https://stacks.cdc.gov/view/cdc/23447. Manlutac, Giesick, McVay (b0045) 2013; 58 Shi, Yang, Wei, Tang, Luo, Deng, Tao (b0095) 2023; 12 Morineau, Nugrahini, Riono, Nurhayati, Girault, Mustikawati (b0205) 2011; 15 Braun, Kouyos, Balmer, Grube, Weber, Günthard (b0210) 2015; 61 Xu, Han, Jiang, Ding, Li, Han, Lv, Chen, Zhang, Cui, Geng, Zhang, Wang, Kang, Li, Sun, Fu, An, Hu, Chu, Liu, Shang (b0005) 2021; 134 Lundgren, Babiker, Gordin, Emery, Grund, Sharma, Avihingsanon, Cooper, Fätkenheuer, Llibre, Molina, Munderi, Schechter, Wood, Klingman, Collins, Lane, Phillips, Neaton (b0015) 2015; 373 Duncan, Duncan, Kramer, Nilsson, Haile, Butcher, Chugh, Baum, Aldrovandi, Young, Avery, Tashima, Valsamakis, Yao, Chang, Coombs (b0085) 2021; 59 ONUSIDA, UNAIDS, Global HIV & AIDS statistics - fact sheet | UNAIDS Unaids. Org. 2020 2020 2021 https://www.unaids.org/en/resources/fact-sheet. Robb, Eller, Kibuuka, Rono, Maganga, Nitayaphan, Kroon, Sawe, Sinei, Sriplienchan, Jagodzinski, Malia, Manak, de Souza, Tovanabutra, Sanders-Buell, Rolland, Dorsey-Spitz, Eller, Milazzo, Li, Lewandowski, Wu, Swann, O’Connell, Peel, Dawson, Kim, Michael (b0125) 2016; 374 Wu, Gong, Hu, Zheng, Wan, Li (b0175) 2021; 97 Musher, Hamill, Baughn (b0180) 1990; 113 Mühlbacher, Sauleda, Piron, Rietz, Permpikul, Klinkicht, Gloeck, Imdahl (b0060) 2019; 112 Pilcher, Tien, Eron, Vernazza, Leu, Stewart, Goh, Cohen (b0120) 2004; 189 Pilcher (10.1016/j.cca.2024.119949_b0115) 2007; 21 Braun (10.1016/j.cca.2024.119949_b0210) 2015; 61 Wu (10.1016/j.cca.2024.119949_b0190) 2022; 10 Hecht (10.1016/j.cca.2024.119949_b0130) 2002; 16 Cohen (10.1016/j.cca.2024.119949_b0035) 2010; 202 Yu (10.1016/j.cca.2024.119949_b0170) 2020; 17 Wu (10.1016/j.cca.2024.119949_b0175) 2021; 97 Consolidated Guidelines on HIV Prevention (10.1016/j.cca.2024.119949_b0030) 2021 Robb (10.1016/j.cca.2024.119949_b0125) 2016; 374 Morineau (10.1016/j.cca.2024.119949_b0205) 2011; 15 Scott (10.1016/j.cca.2024.119949_b0020) 2019; 1 Xu (10.1016/j.cca.2024.119949_b0005) 2021; 134 Mühlbacher (10.1016/j.cca.2024.119949_b0060) 2019; 112 Qiu (10.1016/j.cca.2024.119949_b0165) 2009; 81 Musher (10.1016/j.cca.2024.119949_b0180) 1990; 113 Medina-De la Garza (10.1016/j.cca.2024.119949_b0110) 2021; 25 Gökengin (10.1016/j.cca.2024.119949_b0155) 2014; 25 10.1016/j.cca.2024.119949_b0025 Parker (10.1016/j.cca.2024.119949_b0105) 2019; 116 Pilcher (10.1016/j.cca.2024.119949_b0120) 2004; 189 Manlutac (10.1016/j.cca.2024.119949_b0045) 2013; 58 Smith (10.1016/j.cca.2024.119949_b0140) 2013; 63 Palacios (10.1016/j.cca.2024.119949_b0185) 2007; 44 Rosenberg (10.1016/j.cca.2024.119949_b0145) 2000; 407 Alexander (10.1016/j.cca.2024.119949_b0090) 2016; 23 Livant (10.1016/j.cca.2024.119949_b0075) 2017; 94 Zhang (10.1016/j.cca.2024.119949_b0065) 2020; 92 de Lind (10.1016/j.cca.2024.119949_b0195) 2009; 36 Pham (10.1016/j.cca.2024.119949_b0200) 2015; 91 Yang (10.1016/j.cca.2024.119949_b0070) 2022; 12 Lundgren (10.1016/j.cca.2024.119949_b0015) 2015; 373 10.1016/j.cca.2024.119949_b0050 Pitasi (10.1016/j.cca.2024.119949_b0080) 2020; 47 Shi (10.1016/j.cca.2024.119949_b0095) 2023; 12 10.1016/j.cca.2024.119949_b0150 Krasowski (10.1016/j.cca.2024.119949_b0055) 2021; 6 Cohen (10.1016/j.cca.2024.119949_b0135) 2011; 364 Duncan (10.1016/j.cca.2024.119949_b0085) 2021; 59 Adetunji (10.1016/j.cca.2024.119949_b0040) 2019; 101 Saag (10.1016/j.cca.2024.119949_b0100) 2020; 324 10.1016/j.cca.2024.119949_b0010 Peng (10.1016/j.cca.2024.119949_b0160) 2021; 3 |
| References_xml | – volume: 58 start-page: e44 year: 2013 end-page: e47 ident: b0045 article-title: Identification of early HIV infections using the fourth generation Abbott ARCHITECT HIV Ag/Ab Combo chemiluminescent microparticle immunoassay (CIA) in San Diego County publication-title: J. Clin. Virol. – volume: 364 start-page: 1943 year: 2011 end-page: 1954 ident: b0135 article-title: Acute HIV-1 Infection publication-title: N. Engl. J. Med. – volume: 36 start-page: 319 year: 2009 end-page: 324 ident: b0195 article-title: The epidemiology of human immunodeficiency virus infection, sexually transmitted infections, and associated risk behaviors among men who have sex with men in the Mekong Subregion and China: implications for policy and programming publication-title: Sex. Transm. Dis. – volume: 97 start-page: 525 year: 2021 end-page: 533 ident: b0175 article-title: Effect of syphilis infection on HIV acquisition: a systematic review and meta-analysis publication-title: Sex. Transm. Infect. – volume: 44 start-page: 356 year: 2007 end-page: 359 ident: b0185 article-title: Impact of syphilis infection on HIV viral load and CD4 cell counts in HIV-infected patients publication-title: J. Acquir. Immune Defic. Syndr. – reference: E.M. Lackritz, Prevention of HIV transmission by blood transfusion in the developing world: achievements and continuing challenges, AIDS. 12 Suppl A (1998) S81-6. – volume: 12 year: 2023 ident: b0095 publication-title: A More Comprehensive Clinical and Laboratory Characterization of 61 Acute HIV Infection Patients in Southwest China, Pathog – volume: 6 start-page: 1417 year: 2021 end-page: 1432 ident: b0055 article-title: Real-World Clinical Performance Evaluation of a Fourth-Generation HIV Antigen/Antibody Differentiation Test publication-title: J. Appl. Lab. Med. – volume: 15 start-page: 1033 year: 2011 end-page: 1044 ident: b0205 article-title: Sexual risk taking, STI and HIV prevalence among men who have sex with men in six Indonesian cities publication-title: AIDS Behav. – volume: 101 start-page: 285 year: 2019 end-page: 286 ident: b0040 article-title: Rapid HIV Antigen-Antibody Assays and Detection of Acute HIV Infection in Sub-Saharan Africa publication-title: Am. J. Trop. Med. Hyg. – volume: 47 start-page: S18 year: 2020 end-page: S25 ident: b0080 article-title: Performance of an Alternative Laboratory-Based HIV Diagnostic Testing Algorithm Using HIV-1 RNA Viral Load publication-title: Sex. Transm. Dis. – volume: 374 start-page: 2120 year: 2016 end-page: 2130 ident: b0125 article-title: Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand publication-title: N. Engl. J. Med. – volume: 407 start-page: 523 year: 2000 end-page: 526 ident: b0145 article-title: Immune control of HIV-1 after early treatment of acute infection publication-title: Nature. – volume: 1 start-page: 124 year: 2019 end-page: 128 ident: b0020 article-title: Risks and challenges of HIV infection transmitted via blood transfusion publication-title: Biosaf. Heal. – volume: 63 start-page: S187 year: 2013 end-page: S199 ident: b0140 article-title: The detection and management of early HIV infection: a clinical and public health emergency publication-title: J. Acquir. Immune Defic. Syndr. – volume: 324 start-page: 1651 year: 2020 end-page: 1669 ident: b0100 article-title: Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2020 Recommendations of the International Antiviral Society-USA Panel publication-title: JAMA. – volume: 59 start-page: e0303020 year: 2021 ident: b0085 article-title: An HIV Diagnostic Testing Algorithm Using the cobas HIV-1/HIV-2 Qualitative Assay for HIV Type Differentiation and Confirmation publication-title: J. Clin. Microbiol. – reference: T. Goodhue, A. Kazianis, B.G. Werner, T. Stiles, B.P. Callis, H. Dawn Fukuda, K. Cranston, 4th generation HIV screening in Massachusetts: a partnership between laboratory and program., J. Clin. Virol. 58 Suppl 1 (2013) e13-8. https://doi.org/10.1016/j.jcv.2013.08.019. – volume: 16 start-page: 1119 year: 2002 end-page: 1129 ident: b0130 article-title: Use of laboratory tests and clinical symptoms for identification of primary HIV infection publication-title: AIDS. – volume: 81 start-page: 790 year: 2009 end-page: 797 ident: b0165 article-title: Current HIV-2 diagnostic strategy overestimates HIV-2 prevalence in China publication-title: J. Med. Virol. – volume: 61 start-page: 1013 year: 2015 end-page: 1021 ident: b0210 article-title: Frequency and Spectrum of Unexpected Clinical Manifestations of Primary HIV-1 Infection publication-title: Clin. Infect. Dis. – reference: ONUSIDA, UNAIDS, Global HIV & AIDS statistics - fact sheet | UNAIDS Unaids. Org. 2020 2020 2021 https://www.unaids.org/en/resources/fact-sheet. – volume: 3 start-page: 811 year: 2021 end-page: 812 ident: b0160 article-title: HIV-2 Seroepidemiological Evidence in Hunan Province - China, 2003–2020 publication-title: China CDC Wkly. – volume: 94 start-page: 15 year: 2017 end-page: 21 ident: b0075 article-title: The fourth generation Alere(TM) HIV Combo rapid test improves detection of acute infection in MTN-003 (VOICE) samples publication-title: J. Clin. Virol. off. Publ. Pan Am. Soc. Clin. Virol. – volume: 25 start-page: 695 year: 2014 end-page: 704 ident: b0155 article-title: European Guideline on HIV testing publication-title: Int. J. STD AIDS. – reference: B.M. Branson, S.M. Owen, L.G. Wesolowski, B. Bennett, B.G. Werner, K.E. Wroblewski, M.A. Pentella, Laboratory testing for the diagnosis of HIV infection : updated recommendations (2014), (n.d.). https://stacks.cdc.gov/view/cdc/23447. – volume: 25 start-page: e01168 year: 2021 ident: b0110 article-title: Near misdiagnosis of acute HIV-infection with ELISA-Western Blot scheme: Time for mindset change publication-title: Idcases. – volume: 91 start-page: 178 year: 2015 end-page: 182 ident: b0200 article-title: Men who have sex with men in southern Vietnam report high levels of substance use and sexual risk behaviours but underutilise HIV testing services: a cross-sectional study publication-title: Sex. Transm. Infect. – volume: 189 start-page: 1785 year: 2004 end-page: 1792 ident: b0120 article-title: Brief but efficient: acute HIV infection and the sexual transmission of HIV publication-title: J. Infect. Dis. – volume: 373 start-page: 795 year: 2015 end-page: 807 ident: b0015 article-title: Initiation of antiretroviral therapy in early asymptomatic HIV infection publication-title: N. Engl. J. Med. – volume: 23 start-page: 249 year: 2016 end-page: 253 ident: b0090 article-title: Human Immunodeficiency Virus Diagnostic Testing: 30 Years of Evolution publication-title: Clin. Vaccine Immunol. – volume: 17 start-page: 127 year: 2020 ident: b0170 article-title: Hepatitis B and hepatitis C prevalence among people living with HIV/AIDS in China: a systematic review and Meta-analysis publication-title: Virol. J. – volume: 12 year: 2022 ident: b0070 article-title: Clinical Application Evaluation of Elecsys(®) HIV Duo Assay in Southwest China publication-title: Front. Cell. Infect. Microbiol. – volume: 21 start-page: 1723 year: 2007 end-page: 1730 ident: b0115 article-title: Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection publication-title: AIDS. – year: 2021 ident: b0030 article-title: Testing, Treatment, Service Delivery and Monitoring: Recommendations for a Public Health Approach – volume: 134 start-page: 2799 year: 2021 end-page: 2809 ident: b0005 article-title: Prevention and control of HIV/AIDS in China: lessons from the past three decades publication-title: Chin. Med. J. (engl) – volume: 10 start-page: 1002342 year: 2022 ident: b0190 article-title: Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis publication-title: Front. Public Heal. – volume: 92 start-page: 3230 year: 2020 end-page: 3236 ident: b0065 article-title: Performance evaluation of Elecsys HIV Duo on cobas e 801 using clinical samples in China publication-title: J. Med. Virol. – volume: 116 start-page: 1 year: 2019 end-page: 3 ident: b0105 article-title: BioRad BioPlex® HIV Ag-Ab assay: Incidence of false positivity in a low-prevalence population and its effects on the current HIV testing algorithm publication-title: J. Clin. Virol. – volume: 112 start-page: 45 year: 2019 end-page: 50 ident: b0060 article-title: A multicentre evaluation of the Elecsys(®) HIV Duo assay publication-title: J. Clin. Virol. – volume: 113 start-page: 872 year: 1990 end-page: 881 ident: b0180 article-title: Effect of human immunodeficiency virus (HIV) infection on the course of syphilis and on the response to treatment publication-title: Ann. Intern. Med. – volume: 202 start-page: S270 year: 2010 end-page: S277 ident: b0035 article-title: The Detection of Acute HIV Infection publication-title: J. Infect. Dis. – volume: 113 start-page: 872 year: 1990 ident: 10.1016/j.cca.2024.119949_b0180 article-title: Effect of human immunodeficiency virus (HIV) infection on the course of syphilis and on the response to treatment publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-113-11-872 – ident: 10.1016/j.cca.2024.119949_b0050 doi: 10.1016/j.jcv.2013.08.019 – volume: 112 start-page: 45 year: 2019 ident: 10.1016/j.cca.2024.119949_b0060 article-title: A multicentre evaluation of the Elecsys(®) HIV Duo assay publication-title: J. Clin. Virol. doi: 10.1016/j.jcv.2018.11.005 – volume: 134 start-page: 2799 year: 2021 ident: 10.1016/j.cca.2024.119949_b0005 article-title: Prevention and control of HIV/AIDS in China: lessons from the past three decades publication-title: Chin. Med. J. (engl) doi: 10.1097/CM9.0000000000001842 – volume: 63 start-page: S187 issue: Suppl 2 year: 2013 ident: 10.1016/j.cca.2024.119949_b0140 article-title: The detection and management of early HIV infection: a clinical and public health emergency publication-title: J. Acquir. Immune Defic. Syndr. doi: 10.1097/QAI.0b013e31829871e0 – volume: 12 year: 2022 ident: 10.1016/j.cca.2024.119949_b0070 article-title: Clinical Application Evaluation of Elecsys(®) HIV Duo Assay in Southwest China publication-title: Front. Cell. Infect. Microbiol. doi: 10.3389/fcimb.2022.877643 – volume: 92 start-page: 3230 year: 2020 ident: 10.1016/j.cca.2024.119949_b0065 article-title: Performance evaluation of Elecsys HIV Duo on cobas e 801 using clinical samples in China publication-title: J. Med. Virol. doi: 10.1002/jmv.25845 – ident: 10.1016/j.cca.2024.119949_b0025 – volume: 202 start-page: S270 year: 2010 ident: 10.1016/j.cca.2024.119949_b0035 article-title: The Detection of Acute HIV Infection publication-title: J. Infect. Dis. doi: 10.1086/655651 – volume: 91 start-page: 178 year: 2015 ident: 10.1016/j.cca.2024.119949_b0200 article-title: Men who have sex with men in southern Vietnam report high levels of substance use and sexual risk behaviours but underutilise HIV testing services: a cross-sectional study publication-title: Sex. Transm. Infect. doi: 10.1136/sextrans-2014-051574 – ident: 10.1016/j.cca.2024.119949_b0150 – volume: 23 start-page: 249 year: 2016 ident: 10.1016/j.cca.2024.119949_b0090 article-title: Human Immunodeficiency Virus Diagnostic Testing: 30 Years of Evolution publication-title: Clin. Vaccine Immunol. doi: 10.1128/CVI.00053-16 – volume: 97 start-page: 525 year: 2021 ident: 10.1016/j.cca.2024.119949_b0175 article-title: Effect of syphilis infection on HIV acquisition: a systematic review and meta-analysis publication-title: Sex. Transm. Infect. doi: 10.1136/sextrans-2020-054706 – volume: 116 start-page: 1 year: 2019 ident: 10.1016/j.cca.2024.119949_b0105 article-title: BioRad BioPlex® HIV Ag-Ab assay: Incidence of false positivity in a low-prevalence population and its effects on the current HIV testing algorithm publication-title: J. Clin. Virol. doi: 10.1016/j.jcv.2019.04.002 – volume: 36 start-page: 319 year: 2009 ident: 10.1016/j.cca.2024.119949_b0195 article-title: The epidemiology of human immunodeficiency virus infection, sexually transmitted infections, and associated risk behaviors among men who have sex with men in the Mekong Subregion and China: implications for policy and programming publication-title: Sex. Transm. Dis. doi: 10.1097/OLQ.0b013e318195c302 – volume: 407 start-page: 523 year: 2000 ident: 10.1016/j.cca.2024.119949_b0145 article-title: Immune control of HIV-1 after early treatment of acute infection publication-title: Nature. doi: 10.1038/35035103 – volume: 94 start-page: 15 year: 2017 ident: 10.1016/j.cca.2024.119949_b0075 article-title: The fourth generation Alere(TM) HIV Combo rapid test improves detection of acute infection in MTN-003 (VOICE) samples publication-title: J. Clin. Virol. off. Publ. Pan Am. Soc. Clin. Virol. doi: 10.1016/j.jcv.2017.06.006 – volume: 101 start-page: 285 year: 2019 ident: 10.1016/j.cca.2024.119949_b0040 article-title: Rapid HIV Antigen-Antibody Assays and Detection of Acute HIV Infection in Sub-Saharan Africa publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.19-0144 – volume: 25 start-page: e01168 year: 2021 ident: 10.1016/j.cca.2024.119949_b0110 article-title: Near misdiagnosis of acute HIV-infection with ELISA-Western Blot scheme: Time for mindset change publication-title: Idcases. doi: 10.1016/j.idcr.2021.e01168 – volume: 25 start-page: 695 issue: 2014 year: 2014 ident: 10.1016/j.cca.2024.119949_b0155 article-title: European Guideline on HIV testing publication-title: Int. J. STD AIDS. doi: 10.1177/0956462414531244 – volume: 12 year: 2023 ident: 10.1016/j.cca.2024.119949_b0095 publication-title: A More Comprehensive Clinical and Laboratory Characterization of 61 Acute HIV Infection Patients in Southwest China, Pathog – ident: 10.1016/j.cca.2024.119949_b0010 – volume: 1 start-page: 124 year: 2019 ident: 10.1016/j.cca.2024.119949_b0020 article-title: Risks and challenges of HIV infection transmitted via blood transfusion publication-title: Biosaf. Heal. doi: 10.1016/j.bsheal.2019.12.001 – volume: 16 start-page: 1119 year: 2002 ident: 10.1016/j.cca.2024.119949_b0130 article-title: Use of laboratory tests and clinical symptoms for identification of primary HIV infection publication-title: AIDS. doi: 10.1097/00002030-200205240-00005 – volume: 6 start-page: 1417 year: 2021 ident: 10.1016/j.cca.2024.119949_b0055 article-title: Real-World Clinical Performance Evaluation of a Fourth-Generation HIV Antigen/Antibody Differentiation Test publication-title: J. Appl. Lab. Med. doi: 10.1093/jalm/jfab069 – year: 2021 ident: 10.1016/j.cca.2024.119949_b0030 – volume: 189 start-page: 1785 year: 2004 ident: 10.1016/j.cca.2024.119949_b0120 article-title: Brief but efficient: acute HIV infection and the sexual transmission of HIV publication-title: J. Infect. Dis. doi: 10.1086/386333 – volume: 3 start-page: 811 year: 2021 ident: 10.1016/j.cca.2024.119949_b0160 article-title: HIV-2 Seroepidemiological Evidence in Hunan Province - China, 2003–2020 publication-title: China CDC Wkly. doi: 10.46234/ccdcw2021.190 – volume: 21 start-page: 1723 year: 2007 ident: 10.1016/j.cca.2024.119949_b0115 article-title: Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection publication-title: AIDS. doi: 10.1097/QAD.0b013e3281532c82 – volume: 364 start-page: 1943 year: 2011 ident: 10.1016/j.cca.2024.119949_b0135 article-title: Acute HIV-1 Infection publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra1011874 – volume: 44 start-page: 356 year: 2007 ident: 10.1016/j.cca.2024.119949_b0185 article-title: Impact of syphilis infection on HIV viral load and CD4 cell counts in HIV-infected patients publication-title: J. Acquir. Immune Defic. Syndr. doi: 10.1097/QAI.0b013e31802ea4c6 – volume: 47 start-page: S18 year: 2020 ident: 10.1016/j.cca.2024.119949_b0080 article-title: Performance of an Alternative Laboratory-Based HIV Diagnostic Testing Algorithm Using HIV-1 RNA Viral Load publication-title: Sex. Transm. Dis. doi: 10.1097/OLQ.0000000000001124 – volume: 324 start-page: 1651 year: 2020 ident: 10.1016/j.cca.2024.119949_b0100 article-title: Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2020 Recommendations of the International Antiviral Society-USA Panel publication-title: JAMA. doi: 10.1001/jama.2020.17025 – volume: 373 start-page: 795 year: 2015 ident: 10.1016/j.cca.2024.119949_b0015 article-title: Initiation of antiretroviral therapy in early asymptomatic HIV infection publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1506816 – volume: 59 start-page: e0303020 year: 2021 ident: 10.1016/j.cca.2024.119949_b0085 article-title: An HIV Diagnostic Testing Algorithm Using the cobas HIV-1/HIV-2 Qualitative Assay for HIV Type Differentiation and Confirmation publication-title: J. Clin. Microbiol. doi: 10.1128/JCM.03030-20 – volume: 374 start-page: 2120 year: 2016 ident: 10.1016/j.cca.2024.119949_b0125 article-title: Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1508952 – volume: 10 start-page: 1002342 year: 2022 ident: 10.1016/j.cca.2024.119949_b0190 article-title: Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis publication-title: Front. Public Heal. doi: 10.3389/fpubh.2022.1002342 – volume: 58 start-page: e44 issue: Suppl 1 year: 2013 ident: 10.1016/j.cca.2024.119949_b0045 article-title: Identification of early HIV infections using the fourth generation Abbott ARCHITECT HIV Ag/Ab Combo chemiluminescent microparticle immunoassay (CIA) in San Diego County publication-title: J. Clin. Virol. doi: 10.1016/j.jcv.2013.08.031 – volume: 61 start-page: 1013 year: 2015 ident: 10.1016/j.cca.2024.119949_b0210 article-title: Frequency and Spectrum of Unexpected Clinical Manifestations of Primary HIV-1 Infection publication-title: Clin. Infect. Dis. doi: 10.1093/cid/civ398 – volume: 17 start-page: 127 year: 2020 ident: 10.1016/j.cca.2024.119949_b0170 article-title: Hepatitis B and hepatitis C prevalence among people living with HIV/AIDS in China: a systematic review and Meta-analysis publication-title: Virol. J. doi: 10.1186/s12985-020-01404-z – volume: 15 start-page: 1033 year: 2011 ident: 10.1016/j.cca.2024.119949_b0205 article-title: Sexual risk taking, STI and HIV prevalence among men who have sex with men in six Indonesian cities publication-title: AIDS Behav. doi: 10.1007/s10461-009-9590-6 – volume: 81 start-page: 790 year: 2009 ident: 10.1016/j.cca.2024.119949_b0165 article-title: Current HIV-2 diagnostic strategy overestimates HIV-2 prevalence in China publication-title: J. Med. Virol. doi: 10.1002/jmv.21441 |
| SSID | ssj0004061 |
| Score | 2.4576318 |
| Snippet | •The Elecsys® HIV Duo assay has demonstrated a high specificity of 99.91 % (95 % CI: 99.89 %, 99.93 %) and a high PPV of 0.8516 (95 % CI: 0.8225, 0.8776),... Evaluating the clinical performance of Elecsys HIV Duo assay for primary human immunodeficiency virus (HIV) screening and acute HIV infection detection. This... Evaluating the clinical performance of Elecsys HIV Duo assay for primary human immunodeficiency virus (HIV) screening and acute HIV infection... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 119949 |
| SubjectTerms | Acute Disease Acute HIV infection Adult Diagnostic testing algorithm Female HIV Antibodies - blood HIV Antigens - blood HIV Antigens - immunology HIV Duo HIV Infections - diagnosis HIV screening HIV Testing Humans Male Mass Screening - methods Middle Aged P24 antigen Retrospective Studies |
| Title | Clinical performance evaluation of an HIV Duo assay: From HIV screening to acute and non-acute HIV infection detection |
| URI | https://dx.doi.org/10.1016/j.cca.2024.119949 https://www.ncbi.nlm.nih.gov/pubmed/39241902 https://www.proquest.com/docview/3101793808 |
| Volume | 565 |
| WOSCitedRecordID | wos001310905800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-3492 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0004061 issn: 0009-8981 databaseCode: AIEXJ dateStart: 19950116 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLa6DQEvCAZj5TIZCfHAlKl17rxNpdVApfDQifBkOXY8dZqSbmur8Q_42ZwT20lB2zQeeLFSx26ifl-Pz7HPhZC3OhSFEiLxAl9h01eeSJn2erH0k1AKoFUdKDyOJ5Mky9Jvnc4vFwuzOovLMrm6Suf_FWroA7AxdPYf4G6-FDrgGkCHFmCH9k7AD1ys43wtJqBN6l0f_Jf7R2D2fVxW-6A7izrp0wjjTLAX5AjYtnUUFdyW6EeAm-tlVXrmEw5yPlzoSrswV-tqrn0HDBXHdASYsaMR_-PZEnHNZg0tvy_NwX9VnvwUdiWta4WZzdkf6CzfzjZqf3miKjvU7lkwdA_0TNSmFbNJ7HuYF9GsQtf0WdkcRuGadO1jIuP0WsFv9iBOD4CQYPSz4KAd-2eS7clXPjoej_l0mE3fzc89rD-G5_S2GMsG2WJxmIJ83Dr8NMw-tzG2PZN7172lOyGvfQX_eupNOs5NNkyty0wfk0fWCKGHhjxPSKcot8mDgav9t03uf7EuF0_JyvGJrvGJtnyilaaipEAKCnyiNZ8-UGRT3dewiS7gJvIHRivasKke1LCJNmx6Ro5Hw-ngyLPFOjzpp9HCiwKZSAn2hC-KmDEBWlAgBWO56it0Xw1kpPJeH9og1YwVhci1FhGmt4tCCXrsDtmEZxe7hGqtI5nKSAslglxoESdhnitYPWIR6VR1Sc_9vFzaTPZYUOWMO5fFUw6IcESEG0S65H0zZW7SuNw2OHCYcauHGv2SA9tum_bG4csBLjx4E2VRLS-5b9bBpJd0yXMDfPMWYJ8EoJSzF3eY_ZI8bP9Nr8jm4mJZvCb35Goxu7zYIxtxluxZ3v4GJoy8BA |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Clinical+performance+evaluation+of+an+HIV+Duo+assay%3A+From+HIV+screening+to+acute+and+non-acute+HIV+infection+detection&rft.jtitle=Clinica+chimica+acta&rft.au=Liu%2C+Xin&rft.au=Wu%2C+Chongyang&rft.au=Yuan%2C+Yulin&rft.au=Li%2C+Dongdong&rft.date=2025-01-15&rft.issn=1873-3492&rft.eissn=1873-3492&rft.volume=565&rft.spage=119949&rft_id=info:doi/10.1016%2Fj.cca.2024.119949&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0009-8981&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0009-8981&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0009-8981&client=summon |