Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression

Ulcerative colitis (UC) is a chronic disease characterized by inflammation of intestinal epithelium, primarily of the colon. An increasing prevalence of metabolic syndrome (MetS) in patients with UC has been documented recently. Still, there is no evidence that MetS alters the course of the UC. To t...

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Published in:World journal of gastroenterology : WJG Vol. 25; no. 43; p. 6465
Main Authors: Jovanovic, Marina, Simovic Markovic, Bojana, Gajovic, Nevena, Jurisevic, Milena, Djukic, Aleksandar, Jovanovic, Ivan, Arsenijevic, Nebojsa, Lukic, Aleksandra, Zdravkovic, Natasa
Format: Journal Article
Language:English
Published: United States 21.11.2019
Subjects:
Adult
Aged
Aged, 80 and over
Case-Control Studies
Colitis, Ulcerative - blood
Colitis, Ulcerative - complications
Colitis, Ulcerative - immunology
Colitis, Ulcerative - pathology
Colon - immunology
Colon - pathology
Cytokines - blood
Feces - chemistry
Female
Galectin 3 - blood
Humans
Lymphocytes - metabolism
Male
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Metabolic Syndrome - immunology
Middle Aged
Young Adult
Systemic immune response
Inflammation
Galectin-3
Interleukin-10
Metabolic syndrome
Ulcerative colitis
ISSN:2219-2840, 2219-2840
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Summary:Ulcerative colitis (UC) is a chronic disease characterized by inflammation of intestinal epithelium, primarily of the colon. An increasing prevalence of metabolic syndrome (MetS) in patients with UC has been documented recently. Still, there is no evidence that MetS alters the course of the UC. To test the influence of the MetS on the severity of UC and the local and systemic immune status. Eighty nine patients with histologically confirmed UC were divided in two groups, according to ATP III criteria: Group without MetS (no MetS) and group with MetS. Clinically and histologically milder disease with higher serum level of immunosuppressive cytokine interleukin-10 (IL-10) and fecal content of Galectin-3 (Gal-3) was observed in subjects with UC and MetS, compared to subjects suffering from UC only. This was accompanied with predomination of IL-10 over pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and interleukin-17 (IL-17) in the sera as well as Gal-3 over TNF-α and IL-17 in feces of UC patients with MetS. Further, the patients with both conditions (UC and MetS) had higher percentage of IL-10 producing and Gal-3 expressing innate and acquired immune cells in lamina propria. Local dominance of Gal-3 and IL-10 over pro-inflammatory mediators in patients with MetS may present a mechanism for limiting the inflammatory process and subsequent tissue damage in UC.
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ISSN:2219-2840
2219-2840
DOI:10.3748/wjg.v25.i43.6465