Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue

[Display omitted] Osteoarthritis is a chronic degenerative joint disease affecting millions of people worldwide, with no disease-modifying drugs currently available to treat the disease. Tissue inhibitor of metalloproteinases 3 (TIMP-3) is a potential therapeutic target in osteoarthritis because of...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry Vol. 92; pp. 117424 - 117437
Main Authors:	Green, Jonathan, Tinson, Ryan A.J., Betts, Jacob H.J., Piras, Monica, Pelut, Aylin, Steverding, Dietmar, Wren, Stephen P., Searcey, Mark, Troeberg, Linda
Format:	Journal Article
Language:	English
Published:	OXFORD Elsevier Ltd 07.09.2023 Elsevier
Subjects:	Biochemistry & Molecular Biology Cartilage - metabolism Chemistry Chemistry, Medicinal Chemistry, Organic Humans Life Sciences & Biomedicine Low-density lipoprotein receptor-related protein 1 LRP1 Metalloproteases - metabolism Metalloproteases - pharmacology Metalloproteases - therapeutic use Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - metabolism Pharmacology & Pharmacy Physical Sciences Science & Technology Suramin Suramin - metabolism Suramin - pharmacology Suramin - therapeutic use TIMP-3 Tissue Inhibitor of Metalloproteinase-3 - metabolism Tissue Inhibitor of Metalloproteinase-3 - pharmacology Tissue Inhibitor of Metalloproteinase-3 - therapeutic use EtOAc RAP TIMP-3 Suramin RT SDS LRP1 TBS IL1β ADAMTS Low-density lipoprotein receptor-related protein 1 GAG MTS PVDF CR DMEM MMP OA TCA FCS Osteoarthritis DMMB ENDOCYTOSIS DELIVERY NANOPARTICLES AGGRECANASE RESISTANT ADAMTS5 IN-VIVO DEGRADATION BINDING SULFATED GLYCOSAMINOGLYCANS
ISSN:	0968-0896, 1464-3391, 1464-3391
Online Access:	Get full text
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