Sex- and age-specific reference intervals of 16 steroid metabolites quantified simultaneously by LC-MS/MS in sera from 2458 healthy subjects aged 0 to 77 years
•A novel, specific, and sensitive isotope diluted LC-MS/MS method was developed for simultaneous quantitation of 16 steroid hormone metabolites.•Steroid metabolites in serum from healthy infants, children, adolescents, and adults aged 0.17 months to 77 years (n = 2458) were analysed.•Sex- and age sp...
Gespeichert in:
| Veröffentlicht in: | Clinica chimica acta Jg. 562; S. 119852 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Netherlands
Elsevier B.V
15.08.2024
|
| Schlagworte: | |
| ISSN: | 0009-8981, 1873-3492, 1873-3492 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | •A novel, specific, and sensitive isotope diluted LC-MS/MS method was developed for simultaneous quantitation of 16 steroid hormone metabolites.•Steroid metabolites in serum from healthy infants, children, adolescents, and adults aged 0.17 months to 77 years (n = 2458) were analysed.•Sex- and age specific reference intervals of 15 steroid metabolites were established.
Reference intervals covering the whole life span for all the metabolites in the steroid hormone biosynthesis quantified by sensitive and robust analytical methods are sparse or not existing.
To develop a state-of-the-art LC-MS/MS method for simultaneous quantification of multiple steroid metabolites and to establish detailed sex- and age-specific reference intervals for 16 steroid metabolites.
An isotope diluted LC-MS/MS method was developed for simultaneous quantitation of 16 steroid hormones. Serum samples from cross-sectional cohorts of healthy infants, children, adolescents, and adults aged 0.17 months to 77 years (n = 2458) were analysed.
With this novel, specific, and sensitive LC-MS/MS method, it was possible to quantify progesterone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, dehydroepiandrosterone sulfate, androstenedione, testosterone, dihydrotestosterone, 11-deoxycorticosterone, corticosterone, 11-deoxycortisol, cortisol, and cortisone in ≥90 % of the samples, while estrone sulfate, aldosterone and dehydroepiandrosterone were quantified in 77 %, 75 % and 60 % of the samples, respectively. 21-deoxycortisol was only detectable in 2.5 % of samples from healthy subjects. Sex- and age-dependent fluctuations observed in minipuberty, puberty and adulthood including the menopausal transition were modelled. This enabled us to establish valid reference intervals from birth to late adult life for both males and females.
Detailed sex- and age-specific reference intervals of multiple, simultaneously quantified steroid metabolites by a novel and specific LC-MS/MS method provides a valuable tool for clinical practice and for future research. |
|---|---|
| AbstractList | Reference intervals covering the whole life span for all the metabolites in the steroid hormone biosynthesis quantified by sensitive and robust analytical methods are sparse or not existing.
To develop a state-of-the-art LC-MS/MS method for simultaneous quantification of multiple steroid metabolites and to establish detailed sex- and age-specific reference intervals for 16 steroid metabolites.
An isotope diluted LC-MS/MS method was developed for simultaneous quantitation of 16 steroid hormones. Serum samples from cross-sectional cohorts of healthy infants, children, adolescents, and adults aged 0.17 months to 77 years (n = 2458) were analysed.
With this novel, specific, and sensitive LC-MS/MS method, it was possible to quantify progesterone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, dehydroepiandrosterone sulfate, androstenedione, testosterone, dihydrotestosterone, 11-deoxycorticosterone, corticosterone, 11-deoxycortisol, cortisol, and cortisone in ≥90 % of the samples, while estrone sulfate, aldosterone and dehydroepiandrosterone were quantified in 77 %, 75 % and 60 % of the samples, respectively. 21-deoxycortisol was only detectable in 2.5 % of samples from healthy subjects. Sex- and age-dependent fluctuations observed in minipuberty, puberty and adulthood including the menopausal transition were modelled. This enabled us to establish valid reference intervals from birth to late adult life for both males and females.
Detailed sex- and age-specific reference intervals of multiple, simultaneously quantified steroid metabolites by a novel and specific LC-MS/MS method provides a valuable tool for clinical practice and for future research. Reference intervals covering the whole life span for all the metabolites in the steroid hormone biosynthesis quantified by sensitive and robust analytical methods are sparse or not existing.BACKGROUNDReference intervals covering the whole life span for all the metabolites in the steroid hormone biosynthesis quantified by sensitive and robust analytical methods are sparse or not existing.To develop a state-of-the-art LC-MS/MS method for simultaneous quantification of multiple steroid metabolites and to establish detailed sex- and age-specific reference intervals for 16 steroid metabolites.OBJECTIVETo develop a state-of-the-art LC-MS/MS method for simultaneous quantification of multiple steroid metabolites and to establish detailed sex- and age-specific reference intervals for 16 steroid metabolites.An isotope diluted LC-MS/MS method was developed for simultaneous quantitation of 16 steroid hormones. Serum samples from cross-sectional cohorts of healthy infants, children, adolescents, and adults aged 0.17 months to 77 years (n = 2458) were analysed.MATERIALS AND METHODAn isotope diluted LC-MS/MS method was developed for simultaneous quantitation of 16 steroid hormones. Serum samples from cross-sectional cohorts of healthy infants, children, adolescents, and adults aged 0.17 months to 77 years (n = 2458) were analysed.With this novel, specific, and sensitive LC-MS/MS method, it was possible to quantify progesterone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, dehydroepiandrosterone sulfate, androstenedione, testosterone, dihydrotestosterone, 11-deoxycorticosterone, corticosterone, 11-deoxycortisol, cortisol, and cortisone in ≥90 % of the samples, while estrone sulfate, aldosterone and dehydroepiandrosterone were quantified in 77 %, 75 % and 60 % of the samples, respectively. 21-deoxycortisol was only detectable in 2.5 % of samples from healthy subjects. Sex- and age-dependent fluctuations observed in minipuberty, puberty and adulthood including the menopausal transition were modelled. This enabled us to establish valid reference intervals from birth to late adult life for both males and females.RESULTSWith this novel, specific, and sensitive LC-MS/MS method, it was possible to quantify progesterone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, dehydroepiandrosterone sulfate, androstenedione, testosterone, dihydrotestosterone, 11-deoxycorticosterone, corticosterone, 11-deoxycortisol, cortisol, and cortisone in ≥90 % of the samples, while estrone sulfate, aldosterone and dehydroepiandrosterone were quantified in 77 %, 75 % and 60 % of the samples, respectively. 21-deoxycortisol was only detectable in 2.5 % of samples from healthy subjects. Sex- and age-dependent fluctuations observed in minipuberty, puberty and adulthood including the menopausal transition were modelled. This enabled us to establish valid reference intervals from birth to late adult life for both males and females.Detailed sex- and age-specific reference intervals of multiple, simultaneously quantified steroid metabolites by a novel and specific LC-MS/MS method provides a valuable tool for clinical practice and for future research.CONCLUSIONDetailed sex- and age-specific reference intervals of multiple, simultaneously quantified steroid metabolites by a novel and specific LC-MS/MS method provides a valuable tool for clinical practice and for future research. •A novel, specific, and sensitive isotope diluted LC-MS/MS method was developed for simultaneous quantitation of 16 steroid hormone metabolites.•Steroid metabolites in serum from healthy infants, children, adolescents, and adults aged 0.17 months to 77 years (n = 2458) were analysed.•Sex- and age specific reference intervals of 15 steroid metabolites were established. Reference intervals covering the whole life span for all the metabolites in the steroid hormone biosynthesis quantified by sensitive and robust analytical methods are sparse or not existing. To develop a state-of-the-art LC-MS/MS method for simultaneous quantification of multiple steroid metabolites and to establish detailed sex- and age-specific reference intervals for 16 steroid metabolites. An isotope diluted LC-MS/MS method was developed for simultaneous quantitation of 16 steroid hormones. Serum samples from cross-sectional cohorts of healthy infants, children, adolescents, and adults aged 0.17 months to 77 years (n = 2458) were analysed. With this novel, specific, and sensitive LC-MS/MS method, it was possible to quantify progesterone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, dehydroepiandrosterone sulfate, androstenedione, testosterone, dihydrotestosterone, 11-deoxycorticosterone, corticosterone, 11-deoxycortisol, cortisol, and cortisone in ≥90 % of the samples, while estrone sulfate, aldosterone and dehydroepiandrosterone were quantified in 77 %, 75 % and 60 % of the samples, respectively. 21-deoxycortisol was only detectable in 2.5 % of samples from healthy subjects. Sex- and age-dependent fluctuations observed in minipuberty, puberty and adulthood including the menopausal transition were modelled. This enabled us to establish valid reference intervals from birth to late adult life for both males and females. Detailed sex- and age-specific reference intervals of multiple, simultaneously quantified steroid metabolites by a novel and specific LC-MS/MS method provides a valuable tool for clinical practice and for future research. |
| ArticleNumber | 119852 |
| Author | Lund Kårhus, Line Aksglaede, Lise Andersen, Stine Ehlern Busch, Alexander Siegfried Main, Katharina M. Ljubicic, Marie Lindhardt Andersson, Anna-Maria Flück, Christa E. Linneberg, Allan Jørgensen, Niels Petersen, Jørgen Holm Juul, Anders Hagen, Casper P. Upners, Emmie N. Johannsen, Trine Holm Fischer, Margit Bistrup Frederiksen, Hanne |
| Author_xml | – sequence: 1 givenname: Hanne orcidid: 0000-0002-3180-9879 surname: Frederiksen fullname: Frederiksen, Hanne email: hanne.frederiksen@regionh.dk organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 2 givenname: Trine Holm surname: Johannsen fullname: Johannsen, Trine Holm organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 3 givenname: Stine Ehlern surname: Andersen fullname: Andersen, Stine Ehlern organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 4 givenname: Jørgen Holm surname: Petersen fullname: Petersen, Jørgen Holm organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 5 givenname: Alexander Siegfried surname: Busch fullname: Busch, Alexander Siegfried organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 6 givenname: Marie Lindhardt surname: Ljubicic fullname: Ljubicic, Marie Lindhardt organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 7 givenname: Margit Bistrup surname: Fischer fullname: Fischer, Margit Bistrup organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 8 givenname: Emmie N. surname: Upners fullname: Upners, Emmie N. organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 9 givenname: Casper P. surname: Hagen fullname: Hagen, Casper P. organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 10 givenname: Katharina M. surname: Main fullname: Main, Katharina M. organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 11 givenname: Lise surname: Aksglaede fullname: Aksglaede, Lise organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 12 givenname: Niels surname: Jørgensen fullname: Jørgensen, Niels organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 13 givenname: Line surname: Lund Kårhus fullname: Lund Kårhus, Line organization: Center for Clinical Research and Disease Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, Denmark – sequence: 14 givenname: Allan surname: Linneberg fullname: Linneberg, Allan organization: Center for Clinical Research and Disease Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, Denmark – sequence: 15 givenname: Anna-Maria surname: Andersson fullname: Andersson, Anna-Maria organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark – sequence: 16 givenname: Christa E. surname: Flück fullname: Flück, Christa E. organization: Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, Switzerland – sequence: 17 givenname: Anders surname: Juul fullname: Juul, Anders organization: Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38977173$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kctu3CAUhlGVqpmkfYBuqrPsxhPwBYO6qka9SRN1Me0aYThuGNlmAjjKPE1ftVhOu-giK3Sk7zvA_1-Ri8lPSMhbRreMMn5z3BqjtyUt6y1jUjTlC7Jhoq2KqpblBdlQSmUhpGCX5CrGYx5rytkrclkJ2basrTbk9wEfC9CTBf0Li3hC43pnIGCPASeD4KaE4UEPEXwPjEPMo3cWRky684NLGOF-1lPKHlqIbpyHpCf0cxzO0J1hvytuDze3h7wJIgYNffAjlHUj4A71kO7OEOfuiCbF5Q0WKCQPbQtn1CG-Ji_7fDm-eTqvyc_Pn37svhb771--7T7uC1NJnoqq5V1JZd9xjq3QqLFu6oZXUphS2h6FrTvNrGyskKahSEurO8M6Wjacyrqursn7de8p-PsZY1KjiwaHYf2KqugSGG9amtF3T-jcjWjVKbhRh7P6G2oG2AqY4GPMUf5DGFVLceqocnFqKU6txWWn_c8xLunk_JSCdsOz5ofVxBzPg8OgonFLddaFHKqy3j1j_wHZL7Gg |
| CitedBy_id | crossref_primary_10_1093_oxfimm_iqaf006 crossref_primary_10_1210_jcemcr_luae245 crossref_primary_10_1016_j_nbd_2025_107040 crossref_primary_10_1210_clinem_dgae678 crossref_primary_10_1210_jendso_bvaf105 crossref_primary_10_1002_jssc_70147 |
| Cites_doi | 10.1210/clinem/dgz196 10.1016/j.cca.2014.06.018 10.1016/j.jsbmb.2019.105409 10.1159/000509079 10.1016/j.jsbmb.2014.10.006 10.1007/s00216-016-9512-1 10.1016/j.jpba.2018.11.035 10.1016/j.clinbiochem.2016.04.009 10.1542/peds.2008-2491 10.1201/9780429298547 10.1210/jc.2013-3375 10.1016/j.cca.2023.117304 10.1093/humrep/dey090 10.1289/ehp.0901331 10.1530/EC-23-0073 10.1210/jc.2009-1478 10.1038/s41390-021-01739-5 10.1530/EJE-15-0338 10.1016/j.jsbmb.2016.06.005 10.1016/j.cca.2015.12.042 10.1016/j.cca.2017.05.002 10.1016/j.jsbmb.2023.106366 10.1210/clinem/dgac115 10.1093/ejendo/lvac017 10.3390/toxics10110687 10.1016/j.cca.2017.03.002 10.1530/EJE-16-0953 10.1007/s00216-022-03881-3 10.1111/ppe.12777 10.1016/j.jsbmb.2023.106311 10.1016/j.jmsacl.2022.12.006 10.1016/j.clinms.2018.12.003 10.1210/clinem/dgac363 10.1210/jcem.84.10.6079 |
| ContentType | Journal Article |
| Copyright | 2024 The Authors Copyright © 2024. Published by Elsevier B.V. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2024 The Authors – notice: Copyright © 2024. Published by Elsevier B.V. – notice: Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 |
| DOI | 10.1016/j.cca.2024.119852 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry |
| EISSN | 1873-3492 |
| ExternalDocumentID | 38977173 10_1016_j_cca_2024_119852 S0009898124021041 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 29B 4.4 457 4G. 5GY 5VS 6I. 6J9 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFTH AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABBQC ABFRF ABGSF ABJNI ABMAC ABMZM ABUDA ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJOXV AJRQY AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W K-O KOM L7B MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG RNS ROL RPZ SDF SDG SDP SES SEW SPCBC SSH SSU SSZ T5K WH7 ~02 ~G- .55 .GJ 53G 9DU AAQXK AATTM AAXKI AAYWO AAYXX ABDPE ABFNM ABWVN ABXDB ACIEU ACLOT ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AGRDE AHHHB AIGII AIIUN AKBMS AKYEP ANKPU APXCP ASPBG AVWKF AZFZN CITATION EFKBS EFLBG EJD FEDTE FGOYB G-2 HLW HVGLF HZ~ J5H LX3 M41 R2- SBG WUQ X7M XPP ZGI ~HD AGCQF AGRNS NPM 7X8 |
| ID | FETCH-LOGICAL-c396t-376b209fb66e78aeae45456398c29dfe8d4ba1d95d89c50e02dabc1b025609443 |
| ISICitedReferencesCount | 7 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001270369300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0009-8981 1873-3492 |
| IngestDate | Wed Oct 01 14:09:24 EDT 2025 Mon Jul 21 06:00:24 EDT 2025 Sat Nov 29 05:38:55 EST 2025 Tue Nov 18 22:10:11 EST 2025 Sat Aug 17 15:44:03 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Puberty LC-MS/MS Infant Reference interval Steroid hormone Sex difference |
| Language | English |
| License | This is an open access article under the CC BY license. Copyright © 2024. Published by Elsevier B.V. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c396t-376b209fb66e78aeae45456398c29dfe8d4ba1d95d89c50e02dabc1b025609443 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-3180-9879 |
| OpenAccessLink | https://dx.doi.org/10.1016/j.cca.2024.119852 |
| PMID | 38977173 |
| PQID | 3077176570 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_3077176570 pubmed_primary_38977173 crossref_primary_10_1016_j_cca_2024_119852 crossref_citationtrail_10_1016_j_cca_2024_119852 elsevier_sciencedirect_doi_10_1016_j_cca_2024_119852 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-08-15 |
| PublicationDateYYYYMMDD | 2024-08-15 |
| PublicationDate_xml | – month: 08 year: 2024 text: 2024-08-15 day: 15 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Clinica chimica acta |
| PublicationTitleAlternate | Clin Chim Acta |
| PublicationYear | 2024 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | ICH 2005. ICH Validation of Analytical Procedures:Text and Methodology Q2(R1) 2005 Altinkilic, du Toit, Sakin, Attar, Groessl, Flück (b0165) 2023; 233 Frederiksen, Johannsen, Andersen, Albrethsen, Landersoe, Petersen, Andersen, Vestergaard, Schorring, Linneberg, Main, Andersson, Juul (b0005) 2020; 105 Boas, Frederiksen, Feldt-Rasmussen, Skakkebæk, Hegedüs, Hilsted, Juul, Main (b0125) 2010; 118 Aadahl, Beyer, Linneberg, Thuesen, Jørgensen (b0145) 2006; 1 Schiffer, Kempegowda, Sitch, Adaway, Shaheen, Ebbehoj, Singh, McTaggart, O’Reilly, Prete, Hawley, Keevil, Bancos, Taylor, Arlt (b0065) 2023; 188 Ljubicic, Busch, Upners, Fischer, Petersen, Raket, Frederiksen, Johannsen, Juul, Hagen (b0085) 2022; 107 Clausen, Ljubicic, Main, Andersson, Petersen, Frederiksen, Duno, Johannsen, Juul (b0185) 2020; 93 F. Rigby, Robert A.; Stasinopoulos, Mikis D.; Heller, Gillian Z.; De Bastiani, Distributions for Modeling Location, Scale, and Shape Using GAMLSS in R Chapman HallCRC The R Series, 2019. Damgaard-Olesen, Johannsen, Holmboe, Søeborg, Petersen, Andersson, Aadahl, Linneberg, Juul (b0105) 2016; 454 Bae, Zeidler, Baber, Vogel, Wirkner, Loeffler, Ceglarek, Kiess, Körner, Thiery, Kratzsch (b0115) 2019; 193 L. Priskorn, L. Nordkap, A.K. Bang, M. Krause, S.A. Holmboe, D.L.E. Palme, S.B. Winge, N. Mørup, E. Carlsen, U.N. Joensen, M.B. Jensen, K.M. Main, A. Juul, N.E. Skakkebaek, T.K. Jensen, N. Jørgensen, Average sperm count remains unchanged despite reduction in maternal smoking: results from a large cross-sectional study with annual investigations over 21 years, 33 (2018) 998–1008. Doi Kulle, Krone, Holterhus, Schuler, Greaves, Juul, De Rijke, Hartmann, Saba, Hiort, Wudy (b0180) 2017; 176 Busch, Ljubicic, Upners, Fischer, Raket, Frederiksen, Albrethsen, Johannsen, Hagen, Juul (b0090) 2022; 107 Kunz, Wang, Ferrari, Drey, Theodoropoulou, Schilbach, Reincke, Heier, Peters, Koenig, Zeller, Thorand, Bidlingmaier (b0070) 2024; 13 Li, Kannan (b0055) 2022; 10 Aksglaede, Sørensen, Petersen, Skakkebæk, Juul (b0130) 2009; 123 Eisenhofer, Peitzsch, Kaden, Langton, Pamporaki, Masjkur, Tsatsaronis, Mangelis, Williams, Reincke, Lenders, Bornstein (b0040) 2017; 470 Enver, Vatansever, Guran, Bilgin, Boran, Turan, Haklar, Bereket, Guran (b0095) 2022; 92 Søeborg, Frederiksen, Johannsen, Andersson, Juul (b0080) 2017; 468 K. Sørensen, L. Aksglaede, J.H. Petersen, A. Juul, Recent Changes in Pubertal Timing in Healthy Danish Boys: Associations with Body Mass Index, 95 (2010) 263–270. Doi Keevil (b0015) 2016; 49 Taylor, Keevil, Huhtaniemi (b0020) 2015; 173 . Häkkinen, Murtola, Voutilainen, Poutanen, Linnanen, Koskivuori, Lakka, Jääskeläinen, Auriola (b0045) 2019; 164 Feng, Wang, Li, Shi, Zou, Kong, Xu, Yu, Hu, Xu (b0170) 2023; 543 Busch, Ljubicic, Upners, Fischer, Kolby, Eckert-Lind, Jespersen, Andersson, Frederiksen, Johannsen, Hegaard, Sharif, Hagen, Juul (b0120) 2021; 35 Søeborg, Frederiksen, Mouritsen, Johannsen, Main, Jørgensen, Petersen, Andersson, Juul (b0100) 2014; 437 Boggs, Bowden, Galligan, Guillette, Kucklick (b0030) 2016; 408 Johannsen, Albrethsen, Neocleous, Baronio, Cools, Aksglaede, Jørgensen, Christiansen, Toumba, Fanis, Ljubicic, Juul (b0190) 2023; 12 Šimková, Kolátorová, Drašar, Vítků (b0050) 2022; 1201–1202 Desai, Harwood, Handelsman (b0075) 2019; 11 Andrieu, du Toit, Vogt, Mueller, Groessl (b0110) 2022; 414 Handelsman, Wartofsky (b0010) 2013; 98 Travers, Martinerie, Bouvattier, Boileau, Lombès, Pussard (b0035) 2017; 165 Zhu, Chen, Sang, Chen, Wang, Zhu, Lin, Mao, Zhu (b0175) 2023; 231 Rakete, Schubert, Vogeser (b0060) 2023; 27 Vermeulen, Verdonck, Kaufman (b0155) 1999; 84 Peitzsch, Dekkers, Haase, Sweep, Quack, Antoch, Siegert, Lenders, Deinum, Willenberg, Eisenhofer (b0025) 2015; 145 Bae (10.1016/j.cca.2024.119852_b0115) 2019; 193 Taylor (10.1016/j.cca.2024.119852_b0020) 2015; 173 Busch (10.1016/j.cca.2024.119852_b0090) 2022; 107 Søeborg (10.1016/j.cca.2024.119852_b0080) 2017; 468 Rakete (10.1016/j.cca.2024.119852_b0060) 2023; 27 Søeborg (10.1016/j.cca.2024.119852_b0100) 2014; 437 Busch (10.1016/j.cca.2024.119852_b0120) 2021; 35 Kunz (10.1016/j.cca.2024.119852_b0070) 2024; 13 Travers (10.1016/j.cca.2024.119852_b0035) 2017; 165 Johannsen (10.1016/j.cca.2024.119852_b0190) 2023; 12 Šimková (10.1016/j.cca.2024.119852_b0050) 2022; 1201–1202 10.1016/j.cca.2024.119852_b0150 Feng (10.1016/j.cca.2024.119852_b0170) 2023; 543 Schiffer (10.1016/j.cca.2024.119852_b0065) 2023; 188 Aadahl (10.1016/j.cca.2024.119852_b0145) 2006; 1 Keevil (10.1016/j.cca.2024.119852_b0015) 2016; 49 Häkkinen (10.1016/j.cca.2024.119852_b0045) 2019; 164 Enver (10.1016/j.cca.2024.119852_b0095) 2022; 92 Kulle (10.1016/j.cca.2024.119852_b0180) 2017; 176 Frederiksen (10.1016/j.cca.2024.119852_b0005) 2020; 105 10.1016/j.cca.2024.119852_b0135 Eisenhofer (10.1016/j.cca.2024.119852_b0040) 2017; 470 Damgaard-Olesen (10.1016/j.cca.2024.119852_b0105) 2016; 454 Handelsman (10.1016/j.cca.2024.119852_b0010) 2013; 98 Andrieu (10.1016/j.cca.2024.119852_b0110) 2022; 414 Clausen (10.1016/j.cca.2024.119852_b0185) 2020; 93 Altinkilic (10.1016/j.cca.2024.119852_b0165) 2023; 233 Boggs (10.1016/j.cca.2024.119852_b0030) 2016; 408 Zhu (10.1016/j.cca.2024.119852_b0175) 2023; 231 Boas (10.1016/j.cca.2024.119852_b0125) 2010; 118 10.1016/j.cca.2024.119852_b0140 Vermeulen (10.1016/j.cca.2024.119852_b0155) 1999; 84 Ljubicic (10.1016/j.cca.2024.119852_b0085) 2022; 107 Aksglaede (10.1016/j.cca.2024.119852_b0130) 2009; 123 Li (10.1016/j.cca.2024.119852_b0055) 2022; 10 Desai (10.1016/j.cca.2024.119852_b0075) 2019; 11 Peitzsch (10.1016/j.cca.2024.119852_b0025) 2015; 145 10.1016/j.cca.2024.119852_b0160 |
| References_xml | – volume: 437 start-page: 6 year: 2014 end-page: 13 ident: b0100 article-title: Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults publication-title: Clin. Chim. Acta – volume: 165 start-page: 202 year: 2017 end-page: 211 ident: b0035 article-title: Multiplexed steroid profiling of gluco- and mineralocorticoids pathways using a liquid chromatography tandem mass spectrometry method publication-title: J. Steroid Biochem. Mol. Biol. – volume: 193 year: 2019 ident: b0115 article-title: Reference intervals of nine steroid hormones over the life-span analyzed by LC-MS/MS: Effect of age, gender, puberty, and oral contraceptives publication-title: J. Steroid Biochem. Mol. Biol. – volume: 470 start-page: 115 year: 2017 end-page: 124 ident: b0040 article-title: Reference intervals for plasma concentrations of adrenal steroids measured by LC-MS/MS: Impact of gender, age, oral contraceptives, body mass index and blood pressure status publication-title: Clin. Chim. Acta – volume: 414 start-page: 7461 year: 2022 end-page: 7472 ident: b0110 article-title: Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry publication-title: Anal. Bioanal. Chem. – volume: 35 start-page: 601 year: 2021 end-page: 611 ident: b0120 article-title: Cohort profile: the COPENHAGEN Minipuberty Study—A longitudinal prospective cohort of healthy full-term infants and their parents publication-title: Paediatr. Perinat. Epidemiol. – volume: 408 start-page: 4179 year: 2016 end-page: 4190 ident: b0030 article-title: Development of a multi-class steroid hormone screening method using Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) publication-title: Anal. Bioanal. Chem. – volume: 233 year: 2023 ident: b0165 article-title: The serum steroid signature of PCOS hints at the involvement of novel pathways for excess androgen biosynthesis publication-title: J. Steroid Biochem. Mol. Biol. – volume: 468 start-page: 180 year: 2017 end-page: 186 ident: b0080 article-title: Isotope-dilution TurboFlow-LC-MS/MS method for simultaneous quantification of ten steroid metabolites in serum publication-title: Clin. Chim. Acta – volume: 1 start-page: 1 year: 2006 end-page: 8 ident: b0145 article-title: Grip strength and lower limb extension power in 19–72-year-old Danish men and women: The Health 2006 study publication-title: BMJ Open – volume: 98 start-page: 3971 year: 2013 end-page: 3973 ident: b0010 article-title: Requirement for mass spectrometry sex steroid assays in the journal of clinical endocrinology and metabolism publication-title: J. Clin. Endocrinol. Metab. – volume: 93 start-page: 226 year: 2020 end-page: 238 ident: b0185 article-title: Congenital adrenal hyperplasia in children: a pilot study of steroid hormones expressed as sex- and age-related standard deviation scores publication-title: Horm. Res. Paediatr. – volume: 10 year: 2022 ident: b0055 article-title: Determination of 19 steroid hormones in human serum and urine using liquid chromatography-tandem mass spectrometry publication-title: Toxics – volume: 454 start-page: 82 year: 2016 end-page: 88 ident: b0105 article-title: Reference ranges of 17-hydroxyprogesterone, DHEA, DHEAS, androstenedione, total and free testosterone determined by TurboFlow-LC-MS/MS and associations to health markers in 304 men publication-title: Clin. Chim. Acta – volume: 164 start-page: 642 year: 2019 end-page: 652 ident: b0045 article-title: Simultaneous analysis by LC–MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue publication-title: J. Pharm. Biomed. Anal. – volume: 173 start-page: D1 year: 2015 end-page: D12 ident: b0020 article-title: Mass spectrometry and immunoassay: How to measure steroid hormones today and tomorrow publication-title: Eur. J. Endocrinol. – volume: 118 year: 2010 ident: b0125 article-title: Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth publication-title: Environ. Health Perspect. – volume: 123 year: 2009 ident: b0130 article-title: Recent decline in age at breast development: The Copenhagen puberty study publication-title: Pediatrics – volume: 145 start-page: 75 year: 2015 end-page: 84 ident: b0025 article-title: An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism publication-title: J. Steroid Biochem. Mol. Biol. – volume: 13 year: 2024 ident: b0070 article-title: Age- and sex-adjusted reference intervals for steroid hormones measured by liquid chromatography–tandem mass spectrometry using a widely available kit publication-title: Endocr. Connect. – volume: 231 year: 2023 ident: b0175 article-title: Serum steroid metabolome on the day of oocyte retrieval in women with polycystic ovarian syndrome and its association with pregnancy outcome of in vitro fertilization publication-title: J. Steroid Biochem. Mol. Biol. – volume: 11 start-page: 42 year: 2019 end-page: 51 ident: b0075 article-title: Simultaneous measurement of 18 steroids in human and mouse serum by liquid chromatography–mass spectrometry without derivatization to profile the classical and alternate pathways of androgen synthesis and metabolism publication-title: Clin. Mass Spectrometry – volume: 1201–1202 year: 2022 ident: b0050 article-title: An LC-MS/MS method for the simultaneous quantification of 32 steroids in human plasma publication-title: J. Chromatogr. B Anal. Technol. Biomed. Life Sci. – reference: F. Rigby, Robert A.; Stasinopoulos, Mikis D.; Heller, Gillian Z.; De Bastiani, Distributions for Modeling Location, Scale, and Shape Using GAMLSS in R Chapman HallCRC The R Series, 2019. – reference: L. Priskorn, L. Nordkap, A.K. Bang, M. Krause, S.A. Holmboe, D.L.E. Palme, S.B. Winge, N. Mørup, E. Carlsen, U.N. Joensen, M.B. Jensen, K.M. Main, A. Juul, N.E. Skakkebaek, T.K. Jensen, N. Jørgensen, Average sperm count remains unchanged despite reduction in maternal smoking: results from a large cross-sectional study with annual investigations over 21 years, 33 (2018) 998–1008. Doi: – volume: 107 start-page: 2598 year: 2022 end-page: 2605 ident: b0085 article-title: A biphasic pattern of reproductive hormones in healthy female infants: the COPENHAGEN minipuberty study publication-title: J. Clin. Endocrinol. Metab. – volume: 92 start-page: 265 year: 2022 end-page: 274 ident: b0095 article-title: Adrenal steroids reference ranges in infancy determined by LC-MS/MS publication-title: Pediatr. Res. – volume: 49 start-page: 989 year: 2016 end-page: 997 ident: b0015 article-title: LC–MS/MS analysis of steroids in the clinical laboratory publication-title: Clin. Biochem. – volume: 107 start-page: 1560 year: 2022 end-page: 1568 ident: b0090 article-title: Dynamic changes of reproductive hormones in male minipuberty: temporal dissociation of leydig and sertoli cell activity publication-title: J. Clin. Endocrinol. Metab. – volume: 27 start-page: 40 year: 2023 end-page: 48 ident: b0060 article-title: Semi-automated serum steroid profiling with tandem mass spectrometry publication-title: J. Mass Spectrometry Adv. Clinical Lab – reference: . – volume: 84 start-page: 3666 year: 1999 end-page: 3672 ident: b0155 article-title: A critical evaluation of simple methods for the estimation of free testosterone in serum publication-title: J. Clin. Endocrinol. Metab. – volume: 105 year: 2020 ident: b0005 article-title: Sex-specific estrogen levels and reference intervals from infancy to late adulthood determined by LC-MS/MS publication-title: J. Clin. Endocrinol. Metab. – volume: 543 year: 2023 ident: b0170 article-title: Steroid profiling for the diagnosis of congenital adrenal hyperplasia by microbore ultra-performance liquid chromatography–tandem mass spectrometry publication-title: Clin. Chim. Acta – volume: 176 start-page: P1 year: 2017 end-page: P9 ident: b0180 article-title: Steroid hormone analysis in diagnosis and treatment of DSD: Position paper of Eu COST Action BM 1303 “DSDnet” publication-title: Eur. J. Endocrinol. – volume: 12 year: 2023 ident: b0190 article-title: Reduced serum concentrations of biomarkers reflecting leydig and sertoli cell function in male patients with congenital adrenal hyperplasia publication-title: Endocr. Connect. – volume: 188 year: 2023 ident: b0065 article-title: Classic and 11-oxygenated androgens in serum and saliva across adulthood: a cross-sectional study analyzing the impact of age, body mass index, and diurnal and menstrual cycle variation publication-title: Eur. J. Endocrinol. – reference: ICH 2005. ICH Validation of Analytical Procedures:Text and Methodology Q2(R1) 2005, – reference: K. Sørensen, L. Aksglaede, J.H. Petersen, A. Juul, Recent Changes in Pubertal Timing in Healthy Danish Boys: Associations with Body Mass Index, 95 (2010) 263–270. Doi: – volume: 1201–1202 year: 2022 ident: 10.1016/j.cca.2024.119852_b0050 article-title: An LC-MS/MS method for the simultaneous quantification of 32 steroids in human plasma publication-title: J. Chromatogr. B Anal. Technol. Biomed. Life Sci. – volume: 105 year: 2020 ident: 10.1016/j.cca.2024.119852_b0005 article-title: Sex-specific estrogen levels and reference intervals from infancy to late adulthood determined by LC-MS/MS publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/clinem/dgz196 – volume: 437 start-page: 6 year: 2014 ident: 10.1016/j.cca.2024.119852_b0100 article-title: Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2014.06.018 – volume: 193 year: 2019 ident: 10.1016/j.cca.2024.119852_b0115 article-title: Reference intervals of nine steroid hormones over the life-span analyzed by LC-MS/MS: Effect of age, gender, puberty, and oral contraceptives publication-title: J. Steroid Biochem. Mol. Biol. doi: 10.1016/j.jsbmb.2019.105409 – volume: 93 start-page: 226 year: 2020 ident: 10.1016/j.cca.2024.119852_b0185 article-title: Congenital adrenal hyperplasia in children: a pilot study of steroid hormones expressed as sex- and age-related standard deviation scores publication-title: Horm. Res. Paediatr. doi: 10.1159/000509079 – volume: 145 start-page: 75 year: 2015 ident: 10.1016/j.cca.2024.119852_b0025 article-title: An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism publication-title: J. Steroid Biochem. Mol. Biol. doi: 10.1016/j.jsbmb.2014.10.006 – volume: 408 start-page: 4179 year: 2016 ident: 10.1016/j.cca.2024.119852_b0030 article-title: Development of a multi-class steroid hormone screening method using Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-016-9512-1 – volume: 164 start-page: 642 year: 2019 ident: 10.1016/j.cca.2024.119852_b0045 article-title: Simultaneous analysis by LC–MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2018.11.035 – volume: 49 start-page: 989 year: 2016 ident: 10.1016/j.cca.2024.119852_b0015 article-title: LC–MS/MS analysis of steroids in the clinical laboratory publication-title: Clin. Biochem. doi: 10.1016/j.clinbiochem.2016.04.009 – ident: 10.1016/j.cca.2024.119852_b0150 – volume: 123 year: 2009 ident: 10.1016/j.cca.2024.119852_b0130 article-title: Recent decline in age at breast development: The Copenhagen puberty study publication-title: Pediatrics doi: 10.1542/peds.2008-2491 – ident: 10.1016/j.cca.2024.119852_b0160 doi: 10.1201/9780429298547 – volume: 98 start-page: 3971 year: 2013 ident: 10.1016/j.cca.2024.119852_b0010 article-title: Requirement for mass spectrometry sex steroid assays in the journal of clinical endocrinology and metabolism publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2013-3375 – volume: 543 year: 2023 ident: 10.1016/j.cca.2024.119852_b0170 article-title: Steroid profiling for the diagnosis of congenital adrenal hyperplasia by microbore ultra-performance liquid chromatography–tandem mass spectrometry publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2023.117304 – ident: 10.1016/j.cca.2024.119852_b0140 doi: 10.1093/humrep/dey090 – volume: 1 start-page: 1 issue: 2011 year: 2006 ident: 10.1016/j.cca.2024.119852_b0145 article-title: Grip strength and lower limb extension power in 19–72-year-old Danish men and women: The Health 2006 study publication-title: BMJ Open – volume: 118 year: 2010 ident: 10.1016/j.cca.2024.119852_b0125 article-title: Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth publication-title: Environ. Health Perspect. doi: 10.1289/ehp.0901331 – volume: 12 year: 2023 ident: 10.1016/j.cca.2024.119852_b0190 article-title: Reduced serum concentrations of biomarkers reflecting leydig and sertoli cell function in male patients with congenital adrenal hyperplasia publication-title: Endocr. Connect. doi: 10.1530/EC-23-0073 – ident: 10.1016/j.cca.2024.119852_b0135 doi: 10.1210/jc.2009-1478 – volume: 92 start-page: 265 year: 2022 ident: 10.1016/j.cca.2024.119852_b0095 article-title: Adrenal steroids reference ranges in infancy determined by LC-MS/MS publication-title: Pediatr. Res. doi: 10.1038/s41390-021-01739-5 – volume: 173 start-page: D1 year: 2015 ident: 10.1016/j.cca.2024.119852_b0020 article-title: Mass spectrometry and immunoassay: How to measure steroid hormones today and tomorrow publication-title: Eur. J. Endocrinol. doi: 10.1530/EJE-15-0338 – volume: 165 start-page: 202 year: 2017 ident: 10.1016/j.cca.2024.119852_b0035 article-title: Multiplexed steroid profiling of gluco- and mineralocorticoids pathways using a liquid chromatography tandem mass spectrometry method publication-title: J. Steroid Biochem. Mol. Biol. doi: 10.1016/j.jsbmb.2016.06.005 – volume: 454 start-page: 82 year: 2016 ident: 10.1016/j.cca.2024.119852_b0105 article-title: Reference ranges of 17-hydroxyprogesterone, DHEA, DHEAS, androstenedione, total and free testosterone determined by TurboFlow-LC-MS/MS and associations to health markers in 304 men publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2015.12.042 – volume: 470 start-page: 115 year: 2017 ident: 10.1016/j.cca.2024.119852_b0040 article-title: Reference intervals for plasma concentrations of adrenal steroids measured by LC-MS/MS: Impact of gender, age, oral contraceptives, body mass index and blood pressure status publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2017.05.002 – volume: 13 year: 2024 ident: 10.1016/j.cca.2024.119852_b0070 article-title: Age- and sex-adjusted reference intervals for steroid hormones measured by liquid chromatography–tandem mass spectrometry using a widely available kit publication-title: Endocr. Connect. – volume: 233 year: 2023 ident: 10.1016/j.cca.2024.119852_b0165 article-title: The serum steroid signature of PCOS hints at the involvement of novel pathways for excess androgen biosynthesis publication-title: J. Steroid Biochem. Mol. Biol. doi: 10.1016/j.jsbmb.2023.106366 – volume: 107 start-page: 1560 year: 2022 ident: 10.1016/j.cca.2024.119852_b0090 article-title: Dynamic changes of reproductive hormones in male minipuberty: temporal dissociation of leydig and sertoli cell activity publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/clinem/dgac115 – volume: 188 year: 2023 ident: 10.1016/j.cca.2024.119852_b0065 article-title: Classic and 11-oxygenated androgens in serum and saliva across adulthood: a cross-sectional study analyzing the impact of age, body mass index, and diurnal and menstrual cycle variation publication-title: Eur. J. Endocrinol. doi: 10.1093/ejendo/lvac017 – volume: 10 year: 2022 ident: 10.1016/j.cca.2024.119852_b0055 article-title: Determination of 19 steroid hormones in human serum and urine using liquid chromatography-tandem mass spectrometry publication-title: Toxics doi: 10.3390/toxics10110687 – volume: 468 start-page: 180 year: 2017 ident: 10.1016/j.cca.2024.119852_b0080 article-title: Isotope-dilution TurboFlow-LC-MS/MS method for simultaneous quantification of ten steroid metabolites in serum publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2017.03.002 – volume: 176 start-page: P1 year: 2017 ident: 10.1016/j.cca.2024.119852_b0180 article-title: Steroid hormone analysis in diagnosis and treatment of DSD: Position paper of Eu COST Action BM 1303 “DSDnet” publication-title: Eur. J. Endocrinol. doi: 10.1530/EJE-16-0953 – volume: 414 start-page: 7461 year: 2022 ident: 10.1016/j.cca.2024.119852_b0110 article-title: Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-022-03881-3 – volume: 35 start-page: 601 year: 2021 ident: 10.1016/j.cca.2024.119852_b0120 article-title: Cohort profile: the COPENHAGEN Minipuberty Study—A longitudinal prospective cohort of healthy full-term infants and their parents publication-title: Paediatr. Perinat. Epidemiol. doi: 10.1111/ppe.12777 – volume: 231 year: 2023 ident: 10.1016/j.cca.2024.119852_b0175 article-title: Serum steroid metabolome on the day of oocyte retrieval in women with polycystic ovarian syndrome and its association with pregnancy outcome of in vitro fertilization publication-title: J. Steroid Biochem. Mol. Biol. doi: 10.1016/j.jsbmb.2023.106311 – volume: 27 start-page: 40 year: 2023 ident: 10.1016/j.cca.2024.119852_b0060 article-title: Semi-automated serum steroid profiling with tandem mass spectrometry publication-title: J. Mass Spectrometry Adv. Clinical Lab doi: 10.1016/j.jmsacl.2022.12.006 – volume: 11 start-page: 42 year: 2019 ident: 10.1016/j.cca.2024.119852_b0075 article-title: Simultaneous measurement of 18 steroids in human and mouse serum by liquid chromatography–mass spectrometry without derivatization to profile the classical and alternate pathways of androgen synthesis and metabolism publication-title: Clin. Mass Spectrometry doi: 10.1016/j.clinms.2018.12.003 – volume: 107 start-page: 2598 year: 2022 ident: 10.1016/j.cca.2024.119852_b0085 article-title: A biphasic pattern of reproductive hormones in healthy female infants: the COPENHAGEN minipuberty study publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/clinem/dgac363 – volume: 84 start-page: 3666 year: 1999 ident: 10.1016/j.cca.2024.119852_b0155 article-title: A critical evaluation of simple methods for the estimation of free testosterone in serum publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jcem.84.10.6079 |
| SSID | ssj0004061 |
| Score | 2.48593 |
| Snippet | •A novel, specific, and sensitive isotope diluted LC-MS/MS method was developed for simultaneous quantitation of 16 steroid hormone metabolites.•Steroid... Reference intervals covering the whole life span for all the metabolites in the steroid hormone biosynthesis quantified by sensitive and robust analytical... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 119852 |
| SubjectTerms | Infant LC-MS/MS Puberty Reference interval Sex difference Steroid hormone |
| Title | Sex- and age-specific reference intervals of 16 steroid metabolites quantified simultaneously by LC-MS/MS in sera from 2458 healthy subjects aged 0 to 77 years |
| URI | https://dx.doi.org/10.1016/j.cca.2024.119852 https://www.ncbi.nlm.nih.gov/pubmed/38977173 https://www.proquest.com/docview/3077176570 |
| Volume | 562 |
| WOSCitedRecordID | wos001270369300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-3492 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0004061 issn: 0009-8981 databaseCode: AIEXJ dateStart: 19950116 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6lLQIuCMorPKpF4kTk4sfau3ssUaoSkQopQcrN8mMDCZFdxUmU_Br-F7-GGe_aTotS0QMXy_Hao5Hny87ser4ZQt5HEyeNuM8snnJmMS-yrZh53LInAhxiBCG6SMtmE_zyUozH8mur9bviwqznPMvEZiOv_qup4RoYG6mzdzB3LRQuwDkYHY5gdjj-k-GHamPpEqzflYVESkwG6tTtRMoCEYu1qZrsBB2slJBPU-wlDYBASnKBVMsyiQii0WKKOYdRpvJVMd9itPqlaw2GoN9giJsl2EZCk1Rc5gvDq9x2ilU8KxNFQIu0Y2OIy3lnCy-72I2HTVlS5JRj3QIs7VH7ifMFFrqY_jR7RBdR1qQA9PMf8NOMjJDB2EFyRbOpgfnZenS4xNEednnOGkewrMf7mCvwSSAJtZFh9kFchhu7mglaz-3SElI3gKnmdt9M9Xp2dhwpdL3cvxyH3sOYnQKgT1H6aXPv9SLdN5xnndJYZcvNQhARoohQizggRy73JTiNo7PPvXG_Ye3agVP1-UO9q2_uZfbhDT32RU37VkVldDR6TB6ZZQ0903B8QloqOyYPulU3wWNyf2CSOJ6SX4hQCgiluwilNUJpjVCaT6gTUINQuoNQ2iCUXkcojbe0ROjHwRAkUcQnRXxSxCc1-KQVPlGHlNp0mVPOaYnPZ-TbeW_UvbBMnxAr8WSwRB8Zu7acxEGguIhUpBiuCzwpElemEyVSFkdOKv1UyMS3le2mUZw4cRnuS8a85-QwyzP1klBXKIy5WRCDiMRTsPyBBX8sk8iN7CRgbWJXdggTU0Qfe7nMw732b5MP9SNXuoLMbTezyrihCYF1aBsCUG977F0FhBDsit_89FsPwYVzh2N-W5u80AiptYC1Cg56r-6i4WvysPn3vSGHy8VKvSX3kvVyWixOyAEfixOD9D9z6uS0 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sex-+and+age-specific+reference+intervals+of+16+steroid+metabolites+quantified+simultaneously+by+LC-MS%2FMS+in+sera+from+2458+healthy+subjects+aged+0+to+77+years&rft.jtitle=Clinica+chimica+acta&rft.au=Frederiksen%2C+Hanne&rft.au=Johannsen%2C+Trine+Holm&rft.au=Andersen%2C+Stine+Ehlern&rft.au=Petersen%2C+J%C3%B8rgen+Holm&rft.date=2024-08-15&rft.issn=0009-8981&rft.volume=562&rft.spage=119852&rft_id=info:doi/10.1016%2Fj.cca.2024.119852&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_cca_2024_119852 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0009-8981&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0009-8981&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0009-8981&client=summon |