IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7–mediated Fas ligand cleavage from bronchial epithelial cells

Bronchial epithelial damage and activation likely contribute to the inflammatory and airway-remodeling events characteristic of severe asthma. Interaction of Fas receptor (CD95) with its ligand (FasL; CD95L) is an important mechanism of cell-mediated apoptosis. Bronchial epithelial FasL expression p...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 126; no. 2; pp. 366 - 374.e8
Main Authors:	Wadsworth, Samuel J., Atsuta, Ryo, McIntyre, J. Oliver, Hackett, Tillie-Louise, Singhera, Gurpreet K., Dorscheid, Delbert R.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Limited 01.08.2010
Subjects:	Apoptosis Asthma - genetics Asthma - immunology Asthma - metabolism Asthma - pathology Bronchi - immunology Bronchi - metabolism Bronchi - pathology Cell Line, Transformed Cytokines Disease Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - pathology Experiments Fas Ligand Protein - genetics Fas Ligand Protein - immunology Fas Ligand Protein - metabolism fas Receptor - genetics fas Receptor - immunology fas Receptor - metabolism Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - genetics Gene Expression Regulation, Enzymologic - immunology Humans Interleukin-13 - genetics Interleukin-13 - immunology Interleukin-13 - metabolism Interleukin-13 - pharmacology Interleukin-4 - genetics Interleukin-4 - immunology Interleukin-4 - metabolism Interleukin-9 - genetics Interleukin-9 - immunology Interleukin-9 - metabolism Ligands Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - immunology Matrix Metalloproteinase 7 - biosynthesis Matrix Metalloproteinase 7 - genetics Matrix Metalloproteinase 7 - immunology Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - immunology Models, Biological Respiratory Mucosa - immunology Respiratory Mucosa - metabolism Respiratory Mucosa - pathology RNA, Small Interfering - genetics RNA, Small Interfering - immunology Studies Th2 Cells - immunology Th2 Cells - metabolism Th2 Cells - pathology
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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