Progression from Type 2 Macular Neovascularization to Fibrovascular Pigment Epithelial Detachment

The aim of this study was to report unusual progression of type 2 macular neovascularization (MNV) associated with age-related macular degeneration (AMD), high myopia or angioid streaks. Retrospective multicentric observational case series data were used. Eyes that progressed from type 2 MNV seconda...

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Vydáno v:Vision (Basel) Ročník 5; číslo 2; s. 16
Hlavní autoři: LE, Hoang Mai, Mimoun, Gérard, Cohen, Salomon Y., Jung, Camille, Semoun, Oudy, Souied, Eric H.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 25.03.2021
MDPI
Témata:
Acuity
Age
age-related macular degeneration
angioid streaks
Cysts
Diabetic retinopathy
fibrosis
fibrovascular pigment epithelial detachment
Macular degeneration
macular neovascularization
Medical imaging
Myopia
Retina
Statistical analysis
Vascular endothelial growth factor
Vascularization
France
myopia
angioid streaks
fibrosis
fibrovascular pigment epithelial detachment
macular neovascularization
age-related macular degeneration
ISSN:2411-5150, 2411-5150
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Shrnutí:The aim of this study was to report unusual progression of type 2 macular neovascularization (MNV) associated with age-related macular degeneration (AMD), high myopia or angioid streaks. Retrospective multicentric observational case series data were used. Eyes that progressed from type 2 MNV secondary to AMD, high myopia or angioid streaks to fibrovascular pigment epithelial detachment (PED) were included. A total of 29 treatment-naive eyes from 29 patients with type 2 MNV secondary to AMD (n = 14), high myopia (n = 10) or angioid streaks (n = 5) that progressed to a fibrovascular PED on Spectral Domain-Optical Coherence Tomography were used. This progression occurred within 3 months after anti-VEGF therapy initiation. Logarithm of minimum angle of resolution (LogMAR) visual acuity improved significantly after anti-VEGF therapy, from 0.55 (SD ± 0.30) (20/63–20/80) at baseline to 0.30 (20/40) at 3 months, and 0.33 (20/40) at the final follow-up (mean follow up: 3.68 years). Mean number of intravitreal injections per year for patients with a total follow-up ≥ 12 months (n = 24) was 4.3 ± 2.1 per year. Progression from type 2 MNV to a fibrovascular PED may occur in patients suffering from AMD, high myopia or angioid streaks. This progression appears early after initiation of anti-VEGF therapy and is associated with a favorable visual and anatomical outcome, at least on a short follow up basis.
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SourceType-Scholarly Journals-1
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ISSN:2411-5150
2411-5150
DOI:10.3390/vision5020016