Aspergillus fumigatus –Secreted Alkaline Protease 1 Mediates Airways Hyperresponsiveness in Severe Asthma

The hallmark features of allergic asthma are type 2 (eosinophilic) inflammation and airways hyperresponsiveness (AHR). Although these features often comanifest in mouse lungs in vivo, we demonstrate in this study that the serine protease Alp1 from the ubiquitous mold and allergen, Aspergillus fumiga...

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Veröffentlicht in:	ImmunoHorizons Jg. 3; H. 8; S. 368 - 377
Hauptverfasser:	Redes, Jamie L, Basu, Trisha, Ram-Mohan, Sumati, Ghosh, Chandra C, Chan, Eunice C, Sek, Albert C, Zhao, Ming, Krishnan, Ramaswamy, Rosenberg, Helene F, Druey, Kirk M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 06.08.2019
Schlagworte:	Allergens - immunology Animals Aspergillus fumigatus - enzymology Aspergillus fumigatus - immunology Asthma - immunology Asthma - microbiology Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Bronchoconstriction - drug effects Bronchoconstriction - immunology Cells, Cultured Disease Models, Animal Fungal Proteins - immunology Gene Knockout Techniques Humans Inflammation - immunology Lung - pathology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Myocytes, Smooth Muscle - immunology Receptor, PAR-2 - genetics Receptor, PAR-2 - immunology Serine Endopeptidases - immunology
ISSN:	2573-7732, 2573-7732
Online-Zugang:	Volltext
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