Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

OBJECTIVE: Glycated hemoglobin (HbA1c), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated with increased levels of HbA1c. We aimed to iden...

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Veröffentlicht in:	Diabetes (New York, N.Y.) Jg. 59; H. 12; S. 3229 - 3239
Hauptverfasser:	Soranzo, Nicole, Sanna, Serena, Wheeler, Eleanor, Gieger, Christian, Radke, Dörte, Dupuis, Josée, Bouatia-Naji, Nabila, Langenberg, Claudia, Prokopenko, Inga, Stolerman, Elliot, Sandhu, Manjinder S., Heeney, Matthew M., Devaney, Joseph M., Reilly, Muredach P., Ricketts, Sally L.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Alexandria, VA American Diabetes Association 01.12.2010
Schlagworte:	Biological and medical sciences Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Life Sciences Medical sciences Pharmacology and Therapeutics Endocrinopathy Variant Hemoglobin A1c Diabetes mellitus
ISSN:	0012-1797, 1939-327X
Online-Zugang:	Volltext
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