Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links

ABSTRACT Lysosomal impairment is increasingly recognized as a central event in the pathophysiology of PD. Genetic associations between lysosomal storage disorders, including Gaucher disease and PD, highlight common risk factors and pathological mechanisms. Because the autophagy–lysosomal system is i...

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Bibliographic Details
Published in:	Movement disorders Vol. 31; no. 6; pp. 791 - 801
Main Authors:	Moors, Tim, Paciotti, Silvia, Chiasserini, Davide, Calabresi, Paolo, Parnetti, Lucilla, Beccari, Tommaso, van de Berg, Wilma D. J.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01.06.2016
Subjects:	alpha-Synuclein - metabolism autophagy-lysosomal pathway Biomarkers - cerebrospinal fluid CSF biomarkers GBA Glucocerebrosidase Humans Lysosomal Storage Diseases - cerebrospinal fluid Lysosomal storage disorders Parkinson Disease - cerebrospinal fluid Proteins - metabolism autophagy-lysosomal pathway Glucocerebrosidase Lysosomal storage disorders CSF biomarkers GBA
ISSN:	0885-3185, 1531-8257, 1531-8257
Online Access:	Get full text
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