Purification, characterization and cytotoxicity assessment of Ageritin: The first ribotoxin from the basidiomycete mushroom Agrocybe aegerita

Several species belonging to Ascomycota phylum produce extracellular ribonucleases, known as ribotoxins, which exhibit RNase activity through the cleavage of a single phosphodiester bond, located at the universally conserved sarcin/ricin loop of the large rRNA leading to inhibition of protein biosyn...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1861; no. 5; pp. 1113 - 1121
Main Authors:	Landi, Nicola, Pacifico, Severina, Ragucci, Sara, Iglesias, Rosario, Piccolella, Simona, Amici, Adolfo, Di Giuseppe, Antonella M.A., Di Maro, Antimo
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.05.2017
Subjects:	Agaricales - chemistry Ageritin Agrocybe - chemistry Agrocybe aegerita amino acid composition Amino Acid Sequence antineoplastic activity Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Ascomycota Basidiomycota - chemistry brain Caspase 8 - metabolism Caspase 9 - metabolism caspase-9 Cell Line, Tumor circular dichroism spectroscopy Cytotoxicity Endoribonucleases - metabolism Fungal Proteins - metabolism genetically modified organisms Humans mushrooms neoplasms pest resistance Protein Biosynthesis - drug effects protein synthesis Ribonuclease activity ribonucleases Ribonucleases - chemistry Ribonucleases - pharmacology ribosomal RNA Ribosomes - chemistry Ribosomes - metabolism Ribotoxins ricin Ricin - metabolism RNA, Ribosomal - metabolism structure-activity relationships therapeutics vinblastine Ribotoxins Ribonuclease activity Cytotoxicity Ageritin Agrocybe aegerita Apoptosis
ISSN:	0304-4165, 1872-8006
Online Access:	Get full text
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