Phenanthroline-bis-oxazole ligands for binding and stabilization of G-quadruplexes

G-quadruplexes (G4) are found at important genome regions such as telomere ends and oncogene promoters. One prominent strategy to explore the therapeutic potential of G4 is stabilized it with specific ligands. We report the synthesis of new phenanthroline, phenyl and quinoline acyclic bisoxazole com...

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Veröffentlicht in:	Biochimica et biophysica acta. General subjects Jg. 1861; H. 5; S. 1281 - 1292
Hauptverfasser:	Medeiros-Silva, João, Guédin, Aurore, Salgado, Gilmar F., Mergny, Jean-Louis, Queiroz, João A., Cabrita, Eurico J., Cruz, Carla
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.05.2017
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Binding Sites Circular Dichroism DNA DNA, Neoplasm - chemistry DNA, Neoplasm - drug effects DNA, Neoplasm - metabolism Drug Design fluorescence Fluorescence Resonance Energy Transfer Fluorescence titrations Fret-melting G-quadruplex G-Quadruplexes - drug effects Guanosine - chemistry Humans Ligands Magnetic Resonance Spectroscopy melting nuclear magnetic resonance spectroscopy Nucleic Acid Denaturation oncogenes Oxazoles - chemical synthesis Oxazoles - metabolism Oxazoles - pharmacology Phenanthroline ligands Phenanthrolines - chemical synthesis Phenanthrolines - metabolism Phenanthrolines - pharmacology Promoter Regions, Genetic - drug effects Proto-Oncogene Proteins c-myc - genetics quinoline Structure-Activity Relationship Telomere - chemistry Telomere - drug effects Telomere - metabolism telomeres Temperature topology Fluorescence titrations Phenanthroline ligands Drug design Fret-melting G-quadruplex Circular dichroism
ISSN:	0304-4165, 1872-8006
Online-Zugang:	Volltext
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