Consistent alteration of chain length-specific ceramides in human and mouse fibrotic kidneys

Several studies revealed alterations of single sphingolipid species, such as chain length-specific ceramides, in plasma and serum of patients with kidney diseases. Here, we investigated whether such alterations occur in kidney tissue from patients and mice suffering from renal fibrosis, the common e...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. Molecular and cell biology of lipids Vol. 1866; no. 1; p. 158821
Main Authors:	Eckes, Timon, Trautmann, Sandra, Djudjaj, Sonja, Beyer, Sandra, Patyna, Sammy, Schwalm, Stephanie, Gauer, Stefan, Thomas, Dominique, Schaefer, Liliana, Boor, Peter, Koch, Alexander, Pfeilschifter, Josef
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.01.2021
Subjects:	Actins - genetics Actins - metabolism Adenine - administration & dosage Aged Animals biomarkers Biomarkers - metabolism blood serum Ceramide ceramides Ceramides - classification Ceramides - metabolism Collagen Type I - genetics Collagen Type I - metabolism Collagen Type III - genetics Collagen Type III - metabolism cortex diet Disease Models, Animal Female Fibrosis Gene Expression Regulation Humans Hydronephrosis - chemically induced Hydronephrosis - genetics Hydronephrosis - metabolism Hydronephrosis - pathology Kidney Kidney - metabolism Kidney - pathology kidneys Lipid mediator Lipid Metabolism - genetics Male males Mice Mice, Inbred C57BL Middle Aged neoplasms Nephropathy pyelonephritis Pyelonephritis - chemically induced Pyelonephritis - genetics Pyelonephritis - metabolism Pyelonephritis - pathology Sphingolipids Sphingolipids - classification Sphingolipids - metabolism Ureteral Obstruction - genetics Ureteral Obstruction - metabolism Ureteral Obstruction - pathology Sphingolipids AN Lipid mediator ECM UUO Kidney Cer LC-MS/MS S1P Nephropathy Fibrosis Ceramide CerS CKD
ISSN:	1388-1981, 1879-2618, 1879-2618
Online Access:	Get full text
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