Biodegradation of metformin and guanylurea by aerobic cultures enriched from sludge

Sewage sludge from a municipal wastewater treatment facility employing activated sludge process was pre-incubated with varying substrates and mixtures of substrates including metformin (MET), guanylurea (GUA) and glucose. The biomass from enriched cultures separately utilising MET and glucose/GUA wa...

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Bibliographic Details
Published in:Environmental pollution (1987) Vol. 243; no. Pt A; pp. 255 - 262
Main Authors: Briones, Rowena M., Zhuang, Wei-Qin, Sarmah, Ajit K.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.12.2018
Subjects:
activated sludge
Bacteria, Aerobic - metabolism
Biodegradation
Biodegradation kinetics
Biodegradation, Environmental
biomass
byproducts
carbon
energy
Enrichment cultures
glucose
Glucose - chemistry
Guanylurea
Kinetics
Metformin
Metformin - analogs & derivatives
Metformin - analysis
municipal wastewater
nitrogen
Sewage - chemistry
sewage sludge
Urea - analysis
wastewater treatment
Guanylurea
Biodegradation
Metformin
Biodegradation kinetics
Enrichment cultures
ISSN:0269-7491, 1873-6424, 1873-6424
Online Access:Get full text
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Summary:Sewage sludge from a municipal wastewater treatment facility employing activated sludge process was pre-incubated with varying substrates and mixtures of substrates including metformin (MET), guanylurea (GUA) and glucose. The biomass from enriched cultures separately utilising MET and glucose/GUA was then used to investigate the kinetics of aerobic biodegradation of MET and GUA, respectively, as individual substrates in batch reactors. The results showed that GUA can be completely degraded as a nitrogen source when glucose is provided as a carbon and energy source. On the contrary, MET can be biodegraded as a sole carbon and energy source. However, formation of by-product GUA in solution, which acts as a nitrogen source, rapidly increased the degradation rate of MET resembling autocatalytic behaviour. At low starting concentration of 5 mg/L, the specific substrate utilisation rates of MET and GUA were 0.0033 day−1 and 0.0013 day−1, respectively, which is reported first time in this study. Out of the five biodegradation kinetic models used to describe substrate utilisation, the Quiroga-Sales-Romero (QSR) model was found to predict the measured MET and GUA degradation profile well supported by the goodness of fit parameters. Furthermore, the QSR model was able to describe the autocatalytic degradation of MET and the incomplete biodegradation of GUA in solution. [Display omitted] •Activated sludge culture was enriched with metformin (MET) and/or guanylurea (GUA)•Glucose was also added to some cultures as co-substrate and carbon/energy source•Rapid and complete degradation of MET was observed with concomitant formation of GUA•Absence of glucose led to incomplete degradation of GUA in solution•Glucose provides carbon source for microbes to achieve complete GUA degradation The aerobic biodegradation of metformin and guanylurea as individual substrates was studied in batch reactors using sewage sludge that were pre-incubated with these target compounds.
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ISSN:0269-7491
1873-6424
1873-6424
DOI:10.1016/j.envpol.2018.08.075