Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals

Although most mammalian fatty acids (FAs) are straight-chain, there also exist branched-chain FAs such as iso- and anteiso-FAs, especially in the meibomian glands. Meibum lipids, which are secreted from the meibomian glands and are important for dry eye prevention, contain abundant branched-chain li...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular and cell biology of lipids Jg. 1866; H. 1; S. 158842
Hauptverfasser:	Tanno, Honoka, Sassa, Takayuki, Sawai, Megumi, Kihara, Akio
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.01.2021
Schlagworte:	Acyl Coenzyme A - metabolism Acyltransferases - genetics Acyltransferases - metabolism Aldehyde Oxidoreductases - genetics Aldehyde Oxidoreductases - metabolism Amino Acids, Branched-Chain - classification Amino Acids, Branched-Chain - metabolism Animals Branched-chain fatty acid Ceramide ceramides Ceramides - classification Ceramides - metabolism Cholesterol Esters - classification Cholesterol Esters - metabolism Cholesteryl ester eyes fatty acid elongase Fatty Acid Elongases - genetics Fatty Acid Elongases - metabolism Gene Expression Regulation HEK293 Cells Humans isozymes Lipidomics - methods liquid chromatography liver Liver - metabolism Male Meibomian gland Meibomian Glands - metabolism Mice Mice, Inbred C57BL Mice, Transgenic mutants Skin - metabolism Sterol O-Acyltransferase - genetics Sterol O-Acyltransferase - metabolism Substrate Specificity tandem mass spectrometry tissue distribution Very-long-chain fatty acid Wax ester Crat MS Tg-Elovl1 SOAT TLC MGD MS/MS VLC Meibomian gland ELOVL FAl TFLL FAR AWAT LC Ceramide Branched-chain fatty acid Very-long-chain fatty acid Cholesteryl ester FA Wax ester IVL
ISSN:	1388-1981, 1879-2618, 1879-2618
Online-Zugang:	Volltext
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