Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals

Although most mammalian fatty acids (FAs) are straight-chain, there also exist branched-chain FAs such as iso- and anteiso-FAs, especially in the meibomian glands. Meibum lipids, which are secreted from the meibomian glands and are important for dry eye prevention, contain abundant branched-chain li...

Full description

Saved in:

Bibliographic Details
Published in:	Biochimica et biophysica acta. Molecular and cell biology of lipids Vol. 1866; no. 1; p. 158842
Main Authors:	Tanno, Honoka, Sassa, Takayuki, Sawai, Megumi, Kihara, Akio
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.01.2021
Subjects:	Acyl Coenzyme A - metabolism Acyltransferases - genetics Acyltransferases - metabolism Aldehyde Oxidoreductases - genetics Aldehyde Oxidoreductases - metabolism Amino Acids, Branched-Chain - classification Amino Acids, Branched-Chain - metabolism Animals Branched-chain fatty acid Ceramide ceramides Ceramides - classification Ceramides - metabolism Cholesterol Esters - classification Cholesterol Esters - metabolism Cholesteryl ester eyes fatty acid elongase Fatty Acid Elongases - genetics Fatty Acid Elongases - metabolism Gene Expression Regulation HEK293 Cells Humans isozymes Lipidomics - methods liquid chromatography liver Liver - metabolism Male Meibomian gland Meibomian Glands - metabolism Mice Mice, Inbred C57BL Mice, Transgenic mutants Skin - metabolism Sterol O-Acyltransferase - genetics Sterol O-Acyltransferase - metabolism Substrate Specificity tandem mass spectrometry tissue distribution Very-long-chain fatty acid Wax ester Crat MS Tg-Elovl1 SOAT TLC MGD MS/MS VLC Meibomian gland ELOVL FAl TFLL FAR AWAT LC Ceramide Branched-chain fatty acid Very-long-chain fatty acid Cholesteryl ester FA Wax ester IVL
ISSN:	1388-1981, 1879-2618, 1879-2618
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!