The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia. The receptor for advanced glycation end products (RAGE) is a multiligand receptor that is expressed ubiquitously in the lungs. Engagement of RAGE leads to activation of multiple intracellular signaling pathways, inclu...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 182; no. 7; p. 4349
Main Authors:	van Zoelen, Marieke A D, Schouten, Marcel, de Vos, Alex F, Florquin, Sandrine, Meijers, Joost C M, Nawroth, Peter P, Bierhaus, Angelika, van der Poll, Tom
Format:	Journal Article
Language:	English
Published:	United States 01.04.2009
Subjects:	Animals Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Chemokines - biosynthesis Chemokines - immunology Chemotaxis, Leukocyte - immunology Inflammation - immunology Inflammation - microbiology Inflammation - pathology Mice Mice, Inbred C57BL Mice, Knockout Neutrophils - immunology Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - pathology Receptor for Advanced Glycation End Products Receptors, Immunologic - deficiency Receptors, Immunologic - genetics Receptors, Immunologic - immunology Streptococcus pneumoniae - growth & development
ISSN:	1550-6606, 1550-6606
Online Access:	Get more information
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