Hyaluronic acid engrafted metformin loaded graphene oxide nanoparticle as CD44 targeted anti-cancer therapy for triple negative breast cancer

Triple negative breast cancer (TNBC) is the most aggressive form of breast cancer with limited treatment modalities. It is associated with high propensity of cancer recurrence. UV Spectroscopy, FTIR, DLS, Zeta potential, TEM and SEM were employed to characterize nanoparticles. MTT assay, Wound heali...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1865; no. 3; p. 129841
Main Authors:	Basu, Arijita, Upadhyay, Priyanka, Ghosh, Avijit, Bose, Aparajita, Gupta, Payal, Chattopadhyay, Sreya, Chattopadhyay, Dipankar, Adhikary, Arghya
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.03.2021
Subjects:	Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology apoptosis breast neoplasms cadherins cancer recurrence cancer therapy Cell Line, Tumor cell movement Cell Movement - drug effects Cell Proliferation - drug effects Chick Embryo chick embryos Chorioallantoic Membrane - drug effects Chorioallantoic Membrane - metabolism Chorioallantoic Membrane - pathology Drug Carriers epithelium Female Focal Adhesion Kinase 1 - genetics Focal Adhesion Kinase 1 - metabolism Gene Expression Regulation, Neoplastic - drug effects Graphene oxide Graphite - chemistry Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Hyaluronic acid Hyaluronic Acid - chemistry immunocytochemistry Metformin Metformin - metabolism Metformin - pharmacology Mice Mice, Inbred BALB C microRNA-10b MicroRNAs - genetics MicroRNAs - metabolism Molecular Targeted Therapy Nanoparticles - administration & dosage Nanoparticles - chemistry Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism PTEN PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism remission Signal Transduction toxicity toxicity testing Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Triple negative breast Cancer Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tumor Burden - drug effects Western blotting Xenograft Model Antitumor Assays xenotransplantation zeta potential PTEN Triple negative breast Cancer microRNA-10b Graphene oxide Metformin Hyaluronic acid
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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