AKT/GSK-3β regulates stability and transcription of snail which is crucial for bFGF-induced epithelial–mesenchymal transition of prostate cancer cells

Epithelial–mesenchymal transition (EMT) plays a pivotal role in the development of metastatic cancers. Basic fibroblast growth factor (bFGF) is significantly elevated in metastatic prostate cancers, which has been mentioned mainly to induce EMT in normal cells. However, there is no description about...

Full description

Saved in:

Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1840; no. 10; pp. 3096 - 3105
Main Authors:	Liu, Zong-cai, Wang, Hong-sheng, Zhang, Ge, Liu, Hao, Chen, Xiao-hui, Zhang, Fan, Chen, Dan-yang, Cai, Shao-hui, Du, Jun
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.10.2014
Subjects:	Basic fibroblast growth factor Cell Line, Tumor cell movement Cell Movement - genetics Epithelial-Mesenchymal Transition fibroblast growth factor 2 Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - metabolism fluorescent antibody technique gene expression Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans Invasion Male messenger RNA metastasis neoplasm cells phosphatidylinositol 3-kinase Prostate cancer prostatic neoplasms Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism quantitative polymerase chain reaction reverse transcriptase polymerase chain reaction signal transduction Signal Transduction - genetics Snail Snail Family Transcription Factors snails tau-protein kinase tissue repair Transcription Factors - biosynthesis Transcription Factors - genetics Epithelial–mesenchymal transition Basic fibroblast growth factor Snail Prostate cancer Invasion
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!