Cognitive impairment in major depressive disorder

Cognitive dysfunction is a symptomatic domain identified across many mental disorders. Cognitive deficits in individuals with major depressive disorder (MDD) contribute significantly to occupational and functional disability. Notably, cognitive subdomains such as learning and memory, executive funct...

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Published in:	CNS spectrums Vol. 24; no. 1; pp. 22 - 29
Main Authors:	Pan, Zihang, Park, Caroline, Brietzke, Elisa, Zuckerman, Hannah, Rong, Carola, Mansur, Rodrigo B., Fus, Dominika, Subramaniapillai, Mehala, Lee, Yena, McIntyre, Roger S.
Format:	Journal Article
Language:	English
Published:	United States Cambridge University Press 01.02.2019
Subjects:	Antidepressive Agents - therapeutic use Brain research Cognition Cognition & reasoning Cognition Disorders - complications Cognition Disorders - diagnosis Cognition Disorders - drug therapy Cognitive ability Cold Depressive Disorder, Major - complications Depressive Disorder, Major - diagnosis Depressive Disorder, Major - drug therapy Emotional disorders Executive function Humans Inflammation Insulin resistance Memory Mental depression Mental disorders Metabolism Mood disorders Neurobiology Neurosciences Nootropic Agents - therapeutic use Pathogenesis Remission (Medicine) substrates Cognition cognitive impairment therapeutic implications major depressive disorder (MDD)
ISSN:	1092-8529, 2165-6509
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Abstract	Cognitive dysfunction is a symptomatic domain identified across many mental disorders. Cognitive deficits in individuals with major depressive disorder (MDD) contribute significantly to occupational and functional disability. Notably, cognitive subdomains such as learning and memory, executive functioning, processing speed, and attention and concentration are significantly impaired during, and between, episodes in individuals with MDD. Most antidepressants have not been developed and/or evaluated for their ability to directly and independently ameliorate cognitive deficits. Multiple interacting neurobiological mechanisms (eg, neuroinflammation) are implicated as subserving cognitive deficits in MDD. A testable hypothesis, with preliminary support, posits that improving performance across cognitive domains in individuals with MDD may improve psychosocial function, workplace function, quality of life, and other patient-reported outcomes, independent of effects on core mood symptoms. Herein we aim to (1) provide a rationale for prioritizing cognitive deficits as a therapeutic target, (2) briefly discuss the neurobiological substrates subserving cognitive dysfunction, and (3) provide an update on current and future treatment avenues.
AbstractList	Cognitive dysfunction is a symptomatic domain identified across many mental disorders. Cognitive deficits in individuals with major depressive disorder (MDD) contribute significantly to occupational and functional disability. Notably, cognitive subdomains such as learning and memory, executive functioning, processing speed, and attention and concentration are significantly impaired during, and between, episodes in individuals with MDD. Most antidepressants have not been developed and/or evaluated for their ability to directly and independently ameliorate cognitive deficits. Multiple interacting neurobiological mechanisms (eg, neuroinflammation) are implicated as subserving cognitive deficits in MDD. A testable hypothesis, with preliminary support, posits that improving performance across cognitive domains in individuals with MDD may improve psychosocial function, workplace function, quality of life, and other patient-reported outcomes, independent of effects on core mood symptoms. Herein we aim to (1) provide a rationale for prioritizing cognitive deficits as a therapeutic target, (2) briefly discuss the neurobiological substrates subserving cognitive dysfunction, and (3) provide an update on current and future treatment avenues.Cognitive dysfunction is a symptomatic domain identified across many mental disorders. Cognitive deficits in individuals with major depressive disorder (MDD) contribute significantly to occupational and functional disability. Notably, cognitive subdomains such as learning and memory, executive functioning, processing speed, and attention and concentration are significantly impaired during, and between, episodes in individuals with MDD. Most antidepressants have not been developed and/or evaluated for their ability to directly and independently ameliorate cognitive deficits. Multiple interacting neurobiological mechanisms (eg, neuroinflammation) are implicated as subserving cognitive deficits in MDD. A testable hypothesis, with preliminary support, posits that improving performance across cognitive domains in individuals with MDD may improve psychosocial function, workplace function, quality of life, and other patient-reported outcomes, independent of effects on core mood symptoms. Herein we aim to (1) provide a rationale for prioritizing cognitive deficits as a therapeutic target, (2) briefly discuss the neurobiological substrates subserving cognitive dysfunction, and (3) provide an update on current and future treatment avenues. Cognitive dysfunction is a symptomatic domain identified across many mental disorders. Cognitive deficits in individuals with major depressive disorder (MDD) contribute significantly to occupational and functional disability. Notably, cognitive subdomains such as learning and memory, executive functioning, processing speed, and attention and concentration are significantly impaired during, and between, episodes in individuals with MDD. Most antidepressants have not been developed and/or evaluated for their ability to directly and independently ameliorate cognitive deficits. Multiple interacting neurobiological mechanisms (eg, neuroinflammation) are implicated as subserving cognitive deficits in MDD. A testable hypothesis, with preliminary support, posits that improving performance across cognitive domains in individuals with MDD may improve psychosocial function, workplace function, quality of life, and other patient-reported outcomes, independent of effects on core mood symptoms. Herein we aim to (1) provide a rationale for prioritizing cognitive deficits as a therapeutic target, (2) briefly discuss the neurobiological substrates subserving cognitive dysfunction, and (3) provide an update on current and future treatment avenues.
Author	Lee, Yena Subramaniapillai, Mehala Zuckerman, Hannah McIntyre, Roger S. Brietzke, Elisa Pan, Zihang Rong, Carola Mansur, Rodrigo B. Park, Caroline Fus, Dominika
Author_xml	– sequence: 1 givenname: Zihang surname: Pan fullname: Pan, Zihang – sequence: 2 givenname: Caroline surname: Park fullname: Park, Caroline – sequence: 3 givenname: Elisa orcidid: 0000-0003-2697-1342 surname: Brietzke fullname: Brietzke, Elisa – sequence: 4 givenname: Hannah surname: Zuckerman fullname: Zuckerman, Hannah – sequence: 5 givenname: Carola orcidid: 0000-0002-1408-4968 surname: Rong fullname: Rong, Carola – sequence: 6 givenname: Rodrigo B. surname: Mansur fullname: Mansur, Rodrigo B. – sequence: 7 givenname: Dominika surname: Fus fullname: Fus, Dominika – sequence: 8 givenname: Mehala surname: Subramaniapillai fullname: Subramaniapillai, Mehala – sequence: 9 givenname: Yena orcidid: 0000-0003-0629-9456 surname: Lee fullname: Lee, Yena – sequence: 10 givenname: Roger S. orcidid: 0000-0003-4733-2523 surname: McIntyre fullname: McIntyre, Roger S.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30468135$$D View this record in MEDLINE/PubMed
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Snippet	Cognitive dysfunction is a symptomatic domain identified across many mental disorders. Cognitive deficits in individuals with major depressive disorder (MDD)...
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SubjectTerms	Antidepressive Agents - therapeutic use Brain research Cognition Cognition & reasoning Cognition Disorders - complications Cognition Disorders - diagnosis Cognition Disorders - drug therapy Cognitive ability Cold Depressive Disorder, Major - complications Depressive Disorder, Major - diagnosis Depressive Disorder, Major - drug therapy Emotional disorders Executive function Humans Inflammation Insulin resistance Memory Mental depression Mental disorders Metabolism Mood disorders Neurobiology Neurosciences Nootropic Agents - therapeutic use Pathogenesis Remission (Medicine)
Title	Cognitive impairment in major depressive disorder
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