Plant components can reduce methylmercury toxication: A mini-review

Methylmercury (MeHg) is a ubiquitous environmental pollutant, with the nervous system as its main target; however, the neurotoxic mechanisms of MeHg have not been fully elucidated, and no effective therapeutic and preventive drugs are available to mitigate its toxicity. Recent evidence suggests a re...

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Vydané v:	Biochimica et biophysica acta. General subjects Ročník 1863; číslo 12; s. 129290
Hlavní autori:	Chang, Jie, Zhou, Yun, Wang, Qiang, Aschner, Michael, Lu, Rongzhu
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 01.12.2019
Predmet:	absorption Animals biochemical mechanisms demethylation drugs excretion Humans intestines mercury Methylmercury methylmercury compounds Methylmercury Compounds - pharmacokinetics Methylmercury Compounds - toxicity Natural plant components nervous system Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacokinetics neurotoxicity Neurotoxicity Syndromes - drug therapy Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - pathology plant extracts Plant Extracts - chemistry Plant Extracts - pharmacokinetics Plant Extracts - therapeutic use Plant Structures - chemistry pollutants protective effect therapeutics tissues Toxicity Cd CDC Toxicity CNS HO-1 MDA UC FFQ LDH bw Nrf2 CGNs Methylmercury BME GD GSH EpRE Hg DTPA hNSCs i.g GEE SOD i.p TBARS Natural plant components DMPS BAL GPx MeHg ARE Trolox CAT LC NMDA-R ROS LBPs POEE TP ADA DC
ISSN:	0304-4165, 1872-8006, 1872-8006
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Popis
Shrnutí:	Methylmercury (MeHg) is a ubiquitous environmental pollutant, with the nervous system as its main target; however, the neurotoxic mechanisms of MeHg have not been fully elucidated, and no effective therapeutic and preventive drugs are available to mitigate its toxicity. Recent evidence suggests a reduction in the toxicity of MeHg by natural plant extracts. The aim of this review is to provide an overview of effective natural plant extracts and their putative biochemical mechanisms for blocking gut absorption, enhancing excretion and minimizing toxic effects of MeHg. Natural plant extracts may act as potential therapeutics in response to MeHg exposure. The roles plant components play in the reduction of MeHg toxicity may be multifaceted including: (1) attenuating neurobehavioral deficits; (2) facilitating demethylation of MeHg to inorganic mercury; (3) reducing MeHg absorption from the gastrointestinal tract; (4) redistributing MeHg to less sensitive target organs and tissues; (5) promoting enterohepatic circulation of MeHg to increase its biliary and intestinal excretion; (6) restoring intracellular redox status. The possible protective effects of natural plant components contribute to the understanding of mechanisms of MeHg toxicity and to the development of novel therapeutic strategies. •The roles of plant components in the reduction of MeHg toxicity are multifaceted.•Plant components reduce MeHg absorption from gut and increase its biliary and intestinal excretion.•Plant components facilitate the functional recovery from damage by MeHg.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0304-4165 1872-8006 1872-8006
DOI:	10.1016/j.bbagen.2019.01.012