Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation

The nuclear receptor corepressor (NCoR) was isolated as a peroxisome-proliferator-activated receptor (PPAR) delta interacting protein using the yeast two-hybrid system. NCoR interacted strongly with the ligand-binding domain of PPAR delta, whereas interactions with the ligand-binding domains of PPAR...

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Veröffentlicht in:	Biochemical journal Jg. 363; H. Pt 1; S. 157
Hauptverfasser:	Krogsdam, Anne-M, Nielsen, Curt A F, Neve, Søren, Holst, Dorte, Helledie, Torben, Thomsen, Bo, Bendixen, Christian, Mandrup, Susanne, Kristiansen, Karsten
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.04.2002
Schlagworte:	Animals Cell Line Dimerization DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Glutathione Transferase - metabolism Humans Ligands Mice Nuclear Proteins - metabolism Nuclear Receptor Co-Repressor 1 Nuclear Receptor Co-Repressor 2 Protein Binding Protein Biosynthesis Protein Structure, Tertiary Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - metabolism Recombinant Fusion Proteins - metabolism Repressor Proteins - metabolism Transcription Factors - chemistry Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Transfection Two-Hybrid System Techniques
ISSN:	0264-6021
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