Electrophysiological evaluation of Cystic Fibrosis Conductance Transmembrane Regulator (CFTR) expression in human monocytes

Cystic fibrosis is caused by mutations of CFTR gene, a protein kinase A-activated anion channel, and is associated to a persistent and excessive chronic lung inflammation, suggesting functional alterations of immune cells. Leukocytes express detectable levels of CFTR but the molecule has not been fu...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Biochimica et biophysica acta Ročník 1840; číslo 10; s. 3088 - 3095
Hlavní autoři:	Ettorre, Michele, Verzè, Genny, Caldrer, Sara, Johansson, Jan, Calcaterra, Elisa, Assael, Baroukh Maurice, Melotti, Paola, Sorio, Claudio, Buffelli, Mario
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 01.10.2014
Témata:	Adolescent Adult Amino Acid Sequence confocal microscopy Cystic fibrosis Cystic Fibrosis Conductance Cystic Fibrosis Transmembrane Conductance Regulator - biosynthesis Cystic Fibrosis Transmembrane Conductance Regulator - genetics electrophysiology Female fluorescence Gene Expression Regulation genes Humans inflammation Leukocytes Male Membrane Potentials Middle Aged monocytes Monocytes - cytology Monocytes - metabolism mutation Patch clamp Patch-Clamp Techniques patients protein synthesis Sequence Deletion Transmembrane Regulator CF NPD Vertex-325 Cystic Fibrosis Conductance WCR Patch clamp Cystic fibrosis S.E Leukocytes F508del ICM Transmembrane Regulator CFTRinh-172 CFTR
ISSN:	0304-4165, 0006-3002, 1872-8006
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!