PDT with genetically encoded photosensitizer miniSOG on a tumor spheroid model: A comparative study of continuous-wave and pulsed irradiation

Therapeutic effects of PDT depend on many factors, including the amount of singlet oxygen, localization of photosensitizer and irradiation protocol. The present study was aimed to compare the cytotoxic mechanisms of PDT under continuous-wave (CW) and pulsed irradiation using a tumor spheroid model a...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1865; no. 12; p. 129978
Main Authors:	Yuzhakova, Diana V., Shirmanova, Marina V., Klimenko, Vladimir V., Lukina, Maria M., Gavrina, Alena I., Komarova, Anastasya D., Gorbachev, Dmitry A., Sapogova, Natalya V., Lukyanov, Konstantin A., Kamensky, Vladislav A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.12.2021
Subjects:	3D tumor spheroid model apoptosis Apoptosis - drug effects Apoptosis - radiation effects comparative study Continuous-wave irradiation cytotoxicity Flavin Mononucleotide Fluorescence imaging HeLa Cells Humans irradiation miniSOG neoplasms PDT photobleaching Photochemotherapy - methods photosensitizing agents Photosensitizing Agents - pharmacology Pulsed irradiation singlet oxygen Singlet Oxygen - metabolism Spheroids, Cellular - drug effects Spheroids, Cellular - pathology Spheroids, Cellular - radiation effects therapeutics PDT Fluorescence imaging photodynamic therapy miniSOG phosphate-buffered saline Pulsed irradiation 3D tumor spheroid model photosensitizer dulbecco's modified eagle's medium fetal bovine serum flavin mononucleotide reactive oxygen species ethylenediaminetetraacetic acid Continuous-wave irradiation mini singlet oxygen generator 9,10-anthracenediyl-bis(methylene)dimalonic acid
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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