Synchrotron FTIR microspectroscopy revealed apoptosis-induced biomolecular changes of cholangiocarcinoma cells treated with ursolic acid

Ursolic acid (UA) is a natural triterpenoid which possesses anti-cancer activity. However, little is known regarding the activity and molecular mechanism of UA in cholangiocarcinoma (CCA). Thus, we investigated the effects of UA on growth inhibition and apoptosis induction through biomolecular chang...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1864; no. 12; p. 129708
Main Authors:	Maphanao, Pornpattra, Thanan, Raynoo, Loilome, Watcharin, Chio-Srichan, Sirinart, Wongwattanakul, Molin, Sakonsinsiri, Chadamas
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.12.2020
Subjects:	antineoplastic activity Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Bile Duct Neoplasms - chemistry Bile Duct Neoplasms - drug therapy Bile Duct Neoplasms - pathology Cell Line, Tumor Cholangiocarcinoma Cholangiocarcinoma - chemistry Cholangiocarcinoma - drug therapy Cholangiocarcinoma - pathology cytotoxicity Fourier transform infrared growth retardation Humans lipids Microspectroscopy protein secondary structure Spectroscopy, Fourier Transform Infrared - instrumentation Synchrotron Synchrotrons - instrumentation Triterpenes - pharmacology Ursolic Acid Western blotting CCA PC FTIR Microspectroscopy SR-FTIR Ursolic acid Synchrotron Fourier transform infrared UA Cholangiocarcinoma Apoptosis PCA
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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