Current advances and applications of online sample preparation techniques for miniaturized liquid chromatography systems

•Miniaturized liquid chromatography has been applied in several research fields.•Online coupling of sample preparation techniques with miniaturized systems improve the analytical efficiency.•Online systems boost analytical performance and sensitivity.•Online miniaturized LC configurations, innovativ...

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Veröffentlicht in:Journal of Chromatography A Jg. 1668; S. 462925
Hauptverfasser: Cruz, Jonas Carneiro, Souza, Israel Donizeti de, Lanças, Fernando Mauro, Queiroz, Maria Eugênia Costa
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 12.04.2022
Schlagworte:
Capillary-LC–MS/MS
liquid chromatography
Miniaturization
Nano-LC–MS/MS
Sample preparation
solid phase microextraction
solvents
sorbents
Capillary-LC–MS/MS
Nano-LC–MS/MS
Sample preparation
Miniaturization
ISSN:0021-9673, 1873-3778, 1873-3778
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Abstract •Miniaturized liquid chromatography has been applied in several research fields.•Online coupling of sample preparation techniques with miniaturized systems improve the analytical efficiency.•Online systems boost analytical performance and sensitivity.•Online miniaturized LC configurations, innovative sorbents, and applications are described. Miniaturized liquid chromatography (LC) has been recognized as one of the most important analytical methods in several research fields. Reduced analytical work-scale provides superior chromatographic resolution and decreases sample and organic solvent consumption. However, frequent clogging of tubing connections and use of small sample volumes are significant limitations when high throughput and sensitive analyses are required. Effective sample preparation could help to overcome these limitations. Online coupling of sample preparation techniques (such as column switching and in-tube solid-phase microextraction) with these miniaturized systems may result in more sensitive and reproducible analyses, improving analytical efficiency. This review describes the most common online miniaturized LC configurations, and the main applications of current online sample preparation techniques coupled to miniaturized LC systems in the bioanalytical, omics, and environmental areas. Relevant features, and challenges of these systems, and innovative sorbents, including restricted access materials, monoliths, and immunosorbents is also discussed.
AbstractList Miniaturized liquid chromatography (LC) has been recognized as one of the most important analytical methods in several research fields. Reduced analytical work-scale provides superior chromatographic resolution and decreases sample and organic solvent consumption. However, frequent clogging of tubing connections and use of small sample volumes are significant limitations when high throughput and sensitive analyses are required. Effective sample preparation could help to overcome these limitations. Online coupling of sample preparation techniques (such as column switching and in-tube solid-phase microextraction) with these miniaturized systems may result in more sensitive and reproducible analyses, improving analytical efficiency. This review describes the most common online miniaturized LC configurations, and the main applications of current online sample preparation techniques coupled to miniaturized LC systems in the bioanalytical, omics, and environmental areas. Relevant features, and challenges of these systems, and innovative sorbents, including restricted access materials, monoliths, and immunosorbents is also discussed.Miniaturized liquid chromatography (LC) has been recognized as one of the most important analytical methods in several research fields. Reduced analytical work-scale provides superior chromatographic resolution and decreases sample and organic solvent consumption. However, frequent clogging of tubing connections and use of small sample volumes are significant limitations when high throughput and sensitive analyses are required. Effective sample preparation could help to overcome these limitations. Online coupling of sample preparation techniques (such as column switching and in-tube solid-phase microextraction) with these miniaturized systems may result in more sensitive and reproducible analyses, improving analytical efficiency. This review describes the most common online miniaturized LC configurations, and the main applications of current online sample preparation techniques coupled to miniaturized LC systems in the bioanalytical, omics, and environmental areas. Relevant features, and challenges of these systems, and innovative sorbents, including restricted access materials, monoliths, and immunosorbents is also discussed.
Miniaturized liquid chromatography (LC) has been recognized as one of the most important analytical methods in several research fields. Reduced analytical work-scale provides superior chromatographic resolution and decreases sample and organic solvent consumption. However, frequent clogging of tubing connections and use of small sample volumes are significant limitations when high throughput and sensitive analyses are required. Effective sample preparation could help to overcome these limitations. Online coupling of sample preparation techniques (such as column switching and in-tube solid-phase microextraction) with these miniaturized systems may result in more sensitive and reproducible analyses, improving analytical efficiency. This review describes the most common online miniaturized LC configurations, and the main applications of current online sample preparation techniques coupled to miniaturized LC systems in the bioanalytical, omics, and environmental areas. Relevant features, and challenges of these systems, and innovative sorbents, including restricted access materials, monoliths, and immunosorbents is also discussed.
•Miniaturized liquid chromatography has been applied in several research fields.•Online coupling of sample preparation techniques with miniaturized systems improve the analytical efficiency.•Online systems boost analytical performance and sensitivity.•Online miniaturized LC configurations, innovative sorbents, and applications are described. Miniaturized liquid chromatography (LC) has been recognized as one of the most important analytical methods in several research fields. Reduced analytical work-scale provides superior chromatographic resolution and decreases sample and organic solvent consumption. However, frequent clogging of tubing connections and use of small sample volumes are significant limitations when high throughput and sensitive analyses are required. Effective sample preparation could help to overcome these limitations. Online coupling of sample preparation techniques (such as column switching and in-tube solid-phase microextraction) with these miniaturized systems may result in more sensitive and reproducible analyses, improving analytical efficiency. This review describes the most common online miniaturized LC configurations, and the main applications of current online sample preparation techniques coupled to miniaturized LC systems in the bioanalytical, omics, and environmental areas. Relevant features, and challenges of these systems, and innovative sorbents, including restricted access materials, monoliths, and immunosorbents is also discussed.
ArticleNumber 462925
Author Cruz, Jonas Carneiro
Lanças, Fernando Mauro
Queiroz, Maria Eugênia Costa
Souza, Israel Donizeti de
Author_xml – sequence: 1
  givenname: Jonas Carneiro
  surname: Cruz
  fullname: Cruz, Jonas Carneiro
  organization: Departamento de Química—Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo 14040-901, Brazil
– sequence: 2
  givenname: Israel Donizeti de
  surname: Souza
  fullname: Souza, Israel Donizeti de
  organization: Departamento de Química—Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo 14040-901, Brazil
– sequence: 3
  givenname: Fernando Mauro
  surname: Lanças
  fullname: Lanças, Fernando Mauro
  organization: University of São Paulo, São Carlos, Institute of Chemistry of São Carlos, São Paulo, Brazil
– sequence: 4
  givenname: Maria Eugênia Costa
  surname: Queiroz
  fullname: Queiroz, Maria Eugênia Costa
  email: mariaeqn@ffclrp.usp.br
  organization: Departamento de Química—Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo 14040-901, Brazil
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ISSN 0021-9673
1873-3778
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Keywords Capillary-LC–MS/MS
Nano-LC–MS/MS
Sample preparation
Miniaturization
Language English
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Snippet •Miniaturized liquid chromatography has been applied in several research fields.•Online coupling of sample preparation techniques with miniaturized systems...
Miniaturized liquid chromatography (LC) has been recognized as one of the most important analytical methods in several research fields. Reduced analytical...
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StartPage 462925
SubjectTerms Capillary-LC–MS/MS
liquid chromatography
Miniaturization
Nano-LC–MS/MS
Sample preparation
solid phase microextraction
solvents
sorbents
Title Current advances and applications of online sample preparation techniques for miniaturized liquid chromatography systems
URI https://dx.doi.org/10.1016/j.chroma.2022.462925
https://www.ncbi.nlm.nih.gov/pubmed/35263675
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Volume 1668
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