Structure, function, aging and turnover of aggrecan in the intervertebral disc

Aggrecan is the major non-collagenous component of the intervertebral disc. It is a large proteoglycan possessing numerous glycosaminoglycan chains and the ability to form aggregates in association with hyaluronan. Its abundance and unique molecular features provide the disc with its osmotic propert...

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Veröffentlicht in:	Biochimica et biophysica acta Jg. 1840; H. 10; S. 3181 - 3189
Hauptverfasser:	Sivan, Sarit Sara, Wachtel, Ellen, Roughley, Peter
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.10.2014
Schlagworte:	Aggrecan Aggrecans - metabolism Aging - metabolism Aging - pathology Animals Biomimetics Degeneration glycation Humans hyaluronic acid Intervertebral disc Intervertebral Disc - metabolism Intervertebral Disc - pathology Intervertebral Disc Degeneration - metabolism Intervertebral Disc Degeneration - pathology intervertebral disks metalloproteinases proteoglycans proteolysis Repair scientists Structure-Activity Relationship Turnover CRP NP TNFα ADAMTS Biomimetics Intervertebral disc HYALs Turnover Degeneration Repair Asp CML EGF AF IGD MMPs KS OSM AGEs CEL GAG BMP7 GDF5 ECM IL1 CS IVD TGFβ HA Aggrecan
ISSN:	0304-4165, 0006-3002, 1872-8006
Online-Zugang:	Volltext
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