New thiazolidine-2,4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: Design, synthesis, in silico and in vitro studies

VEGFR-2 has emerged as a prominent positive regulator of cancer progression. Discovery of new anticancer agents and apoptotic inducers targeting VEGFR-2. Design and synthesis of new thiazolidine-2,4-diones followed by extensive in vitro studies, including VEGFR-2 inhibition assay, MTT assay, apoptos...

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Published in:	Biochimica et biophysica acta. General subjects Vol. 1868; no. 6; p. 130599
Main Authors:	Elkady, Hazem, Mahdy, Hazem A., Taghour, Mohammed S., Dahab, Mohammed A., Elwan, Alaa, Hagras, Mohamed, Hussein, Mona H., Ibrahim, Ibrahim M., Husein, Dalal Z., Elkaeed, Eslam B., Alsfouk, Aisha A., Metwaly, Ahmed M., Eissa, Ibrahim H.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.06.2024
Subjects:	Anti-proliferative antineoplastic activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects cell movement Cell Movement - drug effects Cell Proliferation - drug effects computer simulation DFT Docking Drug Design Drug Screening Assays, Antitumor Hep G2 Cells Humans interphase MCF-7 Cells MD simulations Molecular Docking Simulation Molecular Dynamics Simulation neoplasm cells neoplasm progression pharmacokinetics Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Sorafenib - chemistry Sorafenib - pharmacology Thiazolidine-2,4-dione Thiazolidinediones - chemical synthesis Thiazolidinediones - chemistry Thiazolidinediones - pharmacology toxicity toxicity testing vascular endothelial growth factor receptor-2 Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGFR-2 Anti-proliferative DFT VEGFR-2 MD simulations Docking Thiazolidine-2,4-dione Apoptosis
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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