2021 Update of the International Council for Standardization in Haematology Recommendations for Laboratory Measurement of Direct Oral Anticoagulants

Abstract In 2018, the International Council for Standardization in Haematology (ICSH) published a consensus document providing guidance for laboratories on measuring direct oral anticoagulants (DOACs). Since that publication, several significant changes related to DOACs have occurred, including the...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Thrombosis and haemostasis Ročník 121; číslo 8; s. 1008 - 1020
Hlavní autoři: Douxfils, Jonathan, Adcock, Dorothy M., Bates, Shannon M., Favaloro, Emmanuel J., Gouin-Thibault, Isabelle, Guillermo, Cecilia, Kawai, Yohko, Lindhoff-Last, Edelgard, Kitchen, Steve, Gosselin, Robert C.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Rüdigerstraße 14, 70469 Stuttgart, Germany Georg Thieme Verlag KG 01.08.2021
Témata:
Anticoagulation Reversal - standards
Blood Coagulation - drug effects
Blood Coagulation Tests - standards
Consensus
Drug Monitoring - standards
Evidence-Based Medicine
Factor Xa Inhibitors - adverse effects
Factor Xa Inhibitors - blood
Factor Xa Inhibitors - therapeutic use
Hemorrhage - chemically induced
Hemorrhage - prevention & control
Humans
Point-of-Care Testing - standards
Predictive Value of Tests
Reproducibility of Results
Review Article
diagnosis management
direct oral anticoagulants
guidance
laboratory
ISSN:0340-6245, 2567-689X, 2567-689X
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Abstract In 2018, the International Council for Standardization in Haematology (ICSH) published a consensus document providing guidance for laboratories on measuring direct oral anticoagulants (DOACs). Since that publication, several significant changes related to DOACs have occurred, including the approval of a new DOAC by the Food and Drug Administration, betrixaban, and a specific DOAC reversal agent intended for use when the reversal of anticoagulation with apixaban or rivaroxaban is needed due to life-threatening or uncontrolled bleeding, andexanet alfa. In addition, this ICSH Working Party recognized areas where additional information was warranted, including patient population considerations and updates in point-of-care testing. The information in this manuscript supplements our previous ICSH DOAC laboratory guidance document. The recommendations provided are based on (1) information from peer-reviewed publications about laboratory measurement of DOACs, (2) contributing author's personal experience/expert opinion and (3) good laboratory practice.
AbstractList In 2018, the International Council for Standardization in Haematology (ICSH) published a consensus document providing guidance for laboratories on measuring direct oral anticoagulants (DOACs). Since that publication, several significant changes related to DOACs have occurred, including the approval of a new DOAC by the Food and Drug Administration, betrixaban, and a specific DOAC reversal agent intended for use when the reversal of anticoagulation with apixaban or rivaroxaban is needed due to life-threatening or uncontrolled bleeding, andexanet alfa. In addition, this ICSH Working Party recognized areas where additional information was warranted, including patient population considerations and updates in point-of-care testing. The information in this manuscript supplements our previous ICSH DOAC laboratory guidance document. The recommendations provided are based on (1) information from peer-reviewed publications about laboratory measurement of DOACs, (2) contributing author's personal experience/expert opinion and (3) good laboratory practice.
In 2018, the International Council for Standardization in Haematology (ICSH) published a consensus document providing guidance for laboratories on measuring direct oral anticoagulants (DOACs). Since that publication, several significant changes related to DOACs have occurred, including the approval of a new DOAC by the Food and Drug Administration, betrixaban, and a specific DOAC reversal agent intended for use when the reversal of anticoagulation with apixaban or rivaroxaban is needed due to life-threatening or uncontrolled bleeding, andexanet alfa. In addition, this ICSH Working Party recognized areas where additional information was warranted, including patient population considerations and updates in point-of-care testing. The information in this manuscript supplements our previous ICSH DOAC laboratory guidance document. The recommendations provided are based on (1) information from peer-reviewed publications about laboratory measurement of DOACs, (2) contributing author's personal experience/expert opinion and (3) good laboratory practice.In 2018, the International Council for Standardization in Haematology (ICSH) published a consensus document providing guidance for laboratories on measuring direct oral anticoagulants (DOACs). Since that publication, several significant changes related to DOACs have occurred, including the approval of a new DOAC by the Food and Drug Administration, betrixaban, and a specific DOAC reversal agent intended for use when the reversal of anticoagulation with apixaban or rivaroxaban is needed due to life-threatening or uncontrolled bleeding, andexanet alfa. In addition, this ICSH Working Party recognized areas where additional information was warranted, including patient population considerations and updates in point-of-care testing. The information in this manuscript supplements our previous ICSH DOAC laboratory guidance document. The recommendations provided are based on (1) information from peer-reviewed publications about laboratory measurement of DOACs, (2) contributing author's personal experience/expert opinion and (3) good laboratory practice.
Abstract In 2018, the International Council for Standardization in Haematology (ICSH) published a consensus document providing guidance for laboratories on measuring direct oral anticoagulants (DOACs). Since that publication, several significant changes related to DOACs have occurred, including the approval of a new DOAC by the Food and Drug Administration, betrixaban, and a specific DOAC reversal agent intended for use when the reversal of anticoagulation with apixaban or rivaroxaban is needed due to life-threatening or uncontrolled bleeding, andexanet alfa. In addition, this ICSH Working Party recognized areas where additional information was warranted, including patient population considerations and updates in point-of-care testing. The information in this manuscript supplements our previous ICSH DOAC laboratory guidance document. The recommendations provided are based on (1) information from peer-reviewed publications about laboratory measurement of DOACs, (2) contributing author's personal experience/expert opinion and (3) good laboratory practice.
Author Gouin-Thibault, Isabelle
Guillermo, Cecilia
Kitchen, Steve
Douxfils, Jonathan
Bates, Shannon M.
Favaloro, Emmanuel J.
Adcock, Dorothy M.
Kawai, Yohko
Lindhoff-Last, Edelgard
Gosselin, Robert C.
Author_xml – sequence: 1
  givenname: Jonathan
  orcidid: 0000-0002-7644-5298
  surname: Douxfils
  fullname: Douxfils, Jonathan
  email: jonathan.douxfils@unamur.be
  organization: University of Namur, Department of Pharmacy
– sequence: 2
  givenname: Dorothy M.
  surname: Adcock
  fullname: Adcock, Dorothy M.
  organization: Laboratory Corporation of America, Burlington North Carolina, United States
– sequence: 3
  givenname: Shannon M.
  surname: Bates
  fullname: Bates, Shannon M.
  organization: Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
– sequence: 4
  givenname: Emmanuel J.
  surname: Favaloro
  fullname: Favaloro, Emmanuel J.
  organization: Department of Haematology, Sydney Centres for Haemostasis and Thrombosis, Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital, Westmead, New South Wales, Australia
– sequence: 5
  givenname: Isabelle
  surname: Gouin-Thibault
  fullname: Gouin-Thibault, Isabelle
  organization: Department of Hematology-Hemostasis, IRSET-INSERM-1085, University Hospital, Rennes, France
– sequence: 6
  givenname: Cecilia
  surname: Guillermo
  fullname: Guillermo, Cecilia
  organization: Hospital de Clínicas “Dr Manuel Quintela,” Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
– sequence: 7
  givenname: Yohko
  surname: Kawai
  fullname: Kawai, Yohko
  organization: Sanno Hospital, Laboratory Medicine, Tokyo, Japan
– sequence: 8
  givenname: Edelgard
  surname: Lindhoff-Last
  fullname: Lindhoff-Last, Edelgard
  organization: Cardiology Angiology Center Bethanien, CCB Vascular Center, CCB Coagulation Center, Frankfurt, Germany
– sequence: 9
  givenname: Steve
  surname: Kitchen
  fullname: Kitchen, Steve
  organization: Royal Hallamshire Hospital, Coagulation Sheffield, South Yorks, United Kingdom
– sequence: 10
  givenname: Robert C.
  orcidid: 0000-0002-5669-8722
  surname: Gosselin
  fullname: Gosselin, Robert C.
  organization: Hemophilia Treatment Center, University of California, Davis Health System, Sacramento, California, United States
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33742436$$D View this record in MEDLINE/PubMed
BookMark eNo1kUtv1DAUhS1URKeFFXvkJUIK-JlkltUUaKVBlYBK7Kwb-6Z1ldiD7SyG38EPxmnL6i7Od1_nnJGTEAMS8pazj5xp_QkarjRret71L8hG6LZr2n7764RsmFSsaYXSp-Qs5wfGeKu2-hU5lbJTQsl2Q_4KJji9PTgoSONIyz3S61AwBSg-BpjoLi7B-omOMdEfBYKD5PyfR5X6QK8AZyhxindH-h1tnGesyKrmx5Y9DDFVIB3pN4S8JKxAWVdd-oS20JtUl1yE4m2Eu2WCUPJr8nKEKeOb53pObr98_rm7avY3X693F_vGyq0ujewdH1s2Oim5dYqpoXfjCIJ3nRhAaSeVqCLKTjgBHXRDO_IBbS-h7bVV8py8f5p7SPH3grmY2WeLUz0C45KN0NVBxbZ8Rd89o8swozOH5GdIR_PfyQp8eALKva8vmoe4VA-nbDgza0wGzBqTWWOS_wB0WYaR
CitedBy_id crossref_primary_10_1186_s12959_024_00591_x
crossref_primary_10_1016_j_thromres_2024_01_017
crossref_primary_10_1038_s41467_024_48278_1
crossref_primary_10_1016_j_ejim_2023_07_029
crossref_primary_10_3389_fcvm_2024_1495377
crossref_primary_10_1007_s10309_022_00478_9
crossref_primary_10_1111_ijlh_14347
crossref_primary_10_1111_ijlh_14506
crossref_primary_10_1055_s_0041_1741072
crossref_primary_10_1002_cam4_7430
crossref_primary_10_1016_j_rpth_2025_102969
crossref_primary_10_1002_ams2_954
crossref_primary_10_1080_14740338_2025_2490847
crossref_primary_10_1055_a_1753_2748
crossref_primary_10_1002_cpt_2649
crossref_primary_10_1055_s_0043_1777859
crossref_primary_10_1111_ijlh_14357
crossref_primary_10_2478_acph_2022_0034
crossref_primary_10_1007_s10072_023_06992_6
crossref_primary_10_1055_a_2446_1348
crossref_primary_10_1177_10760296221084307
crossref_primary_10_3389_fphar_2025_1563745
crossref_primary_10_1111_imj_70103
crossref_primary_10_1080_00365513_2024_2369993
crossref_primary_10_3390_jcm13123612
crossref_primary_10_36290_vnl_2023_087
crossref_primary_10_3390_jcm11216369
crossref_primary_10_1007_s00399_022_00898_0
crossref_primary_10_1002_rth2_12804
crossref_primary_10_1186_s12959_024_00659_8
crossref_primary_10_3390_diagnostics13122128
crossref_primary_10_1111_ijlh_14004
crossref_primary_10_1007_s10309_024_00708_2
crossref_primary_10_1016_j_cll_2024_04_014
crossref_primary_10_1097_ACO_0000000000001356
crossref_primary_10_3390_jcm14082591
crossref_primary_10_1055_a_2173_7729
crossref_primary_10_1016_j_rpth_2023_100201
crossref_primary_10_1182_bloodadvances_2023012408
crossref_primary_10_1016_j_rpth_2024_102426
crossref_primary_10_1177_10760296231179684
crossref_primary_10_1053_j_jvca_2022_07_016
crossref_primary_10_3390_transplantology3030022
crossref_primary_10_1111_aas_14209
crossref_primary_10_1111_epi_18144
crossref_primary_10_1007_s40140_024_00631_2
crossref_primary_10_1097_TP_0000000000004195
crossref_primary_10_1002_rth2_12650
crossref_primary_10_1038_s41598_024_74481_7
crossref_primary_10_1016_j_rpth_2025_102950
crossref_primary_10_1177_00185787221150928
crossref_primary_10_1007_s00415_024_12832_0
crossref_primary_10_1016_j_jacc_2021_07_059
crossref_primary_10_1111_ijlh_13692
crossref_primary_10_1093_eurheartjsupp_suae033
crossref_primary_10_1055_a_2136_2391
crossref_primary_10_1111_ijlh_14300
crossref_primary_10_1007_s00210_025_04352_z
crossref_primary_10_3390_jcm14155476
crossref_primary_10_1111_imj_16329
crossref_primary_10_1182_bloodadvances_2024013126
crossref_primary_10_1055_a_2261_1811
crossref_primary_10_1111_ctr_14474
crossref_primary_10_1055_s_0043_1763254
crossref_primary_10_1016_j_jtha_2025_02_026
crossref_primary_10_1055_s_0044_1782196
crossref_primary_10_1007_s10557_025_07691_4
crossref_primary_10_1111_acem_14537
crossref_primary_10_1016_j_jtha_2025_02_025
crossref_primary_10_7326_AITC202209200
crossref_primary_10_1016_j_jemermed_2025_05_013
crossref_primary_10_4081_btvb_2022_37
crossref_primary_10_1002_rth2_12676
crossref_primary_10_1016_j_rpth_2023_100196
crossref_primary_10_1016_j_jtha_2024_04_022
crossref_primary_10_3389_fcvm_2022_1052053
crossref_primary_10_3390_jcm14031006
crossref_primary_10_1007_s11886_023_01858_x
crossref_primary_10_1016_j_thromres_2024_04_029
crossref_primary_10_3390_life12050705
crossref_primary_10_1111_jth_15884
crossref_primary_10_3389_fcvm_2022_991675
crossref_primary_10_3390_life12071027
crossref_primary_10_1002_pbc_29888
crossref_primary_10_5858_arpa_2023_0030_OA
crossref_primary_10_3389_fneur_2024_1294022
crossref_primary_10_1007_s10047_023_01392_1
crossref_primary_10_1111_ijlh_14288
crossref_primary_10_3389_fcvm_2022_856222
crossref_primary_10_1111_ijlh_14166
crossref_primary_10_1016_j_jtha_2025_06_016
crossref_primary_10_1097_FTD_0000000000001301
crossref_primary_10_1016_j_jtha_2024_12_005
crossref_primary_10_1007_s11239_023_02790_1
crossref_primary_10_1016_j_chest_2022_07_025
crossref_primary_10_1002_rth2_12680
crossref_primary_10_1016_j_tru_2025_100223
crossref_primary_10_1080_17425255_2023_2287472
crossref_primary_10_1016_j_cca_2023_117565
crossref_primary_10_1177_10760296241246004
crossref_primary_10_3390_jcm11082236
crossref_primary_10_1007_s00101_022_01142_7
crossref_primary_10_1007_s00520_022_07533_1
crossref_primary_10_1111_ijlh_14052
crossref_primary_10_1007_s00101_025_01524_7
crossref_primary_10_1097_ALN_0000000000003903
crossref_primary_10_1055_a_2112_1834
crossref_primary_10_1007_s40256_022_00536_7
crossref_primary_10_1016_j_ijpharm_2023_123626
crossref_primary_10_3389_fphar_2022_928401
crossref_primary_10_1093_eurheartj_suab153
crossref_primary_10_1016_j_thromres_2024_04_005
crossref_primary_10_1055_s_0042_1750327
crossref_primary_10_1177_87551225231207273
crossref_primary_10_1186_s12959_023_00501_7
crossref_primary_10_1007_s00068_022_02041_7
crossref_primary_10_1038_s41598_024_57648_0
crossref_primary_10_1007_s11239_025_03159_2
crossref_primary_10_1016_S2211_0364_24_64141_5
crossref_primary_10_1055_a_1981_1763
crossref_primary_10_1007_s00101_023_01368_z
crossref_primary_10_1007_s00228_025_03871_1
ContentType Journal Article
Copyright Thieme. All rights reserved.
Copyright_xml – notice: Thieme. All rights reserved.
DBID 0U6
CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1055/a-1450-8178
DatabaseName Thieme Connect Journals Open Access
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: 0U6
  name: Thieme Connect Journals Open Access
  url: http://open.thieme.com
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2567-689X
EndPage 1020
ExternalDocumentID 33742436
10_1055_a_1450_8178
Genre Journal Article
Practice Guideline
Review
GroupedDBID ---
.55
.GJ
0R~
0U6
0VX
123
1KJ
4.4
53G
5RE
AAQQT
ABJNI
ABOCM
ACGFO
ACGFS
AENEX
AFFNX
AHRSK
ALMA_UNASSIGNED_HOLDINGS
BR6
C45
CS3
DU5
EBS
EJD
F5P
H13
J5H
OVD
P2P
RTC
RTE
SJN
TEORI
X7M
ZGI
ZXP
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ID FETCH-LOGICAL-c395t-38d1f60fd331cd404b8dffa21772ba45d342fd3e372d2a7a7b6f1bec83a685c43
IEDL.DBID 0U6
ISICitedReferencesCount 163
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000656036000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0340-6245
2567-689X
IngestDate Thu Jul 10 22:59:31 EDT 2025
Thu Jan 02 22:55:27 EST 2025
Sun Nov 24 14:59:55 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Keywords diagnosis management
direct oral anticoagulants
guidance
laboratory
Language English
License Thieme. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c395t-38d1f60fd331cd404b8dffa21772ba45d342fd3e372d2a7a7b6f1bec83a685c43
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Instructional Material/Guideline-3
ObjectType-Review-4
content type line 23
ORCID 0000-0002-7644-5298
0000-0002-5669-8722
OpenAccessLink http://dx.doi.org/10.1055/a-1450-8178
PMID 33742436
PQID 2503440914
PQPubID 23479
PageCount 13
ParticipantIDs proquest_miscellaneous_2503440914
pubmed_primary_33742436
thieme_journals_10_1055_a_1450_8178
PublicationCentury 2000
PublicationDate 20210800
2021-Aug
20210801
PublicationDateYYYYMMDD 2021-08-01
PublicationDate_xml – month: 08
  year: 2021
  text: 20210800
PublicationDecade 2020
PublicationPlace Rüdigerstraße 14, 70469 Stuttgart, Germany
PublicationPlace_xml – name: Rüdigerstraße 14, 70469 Stuttgart, Germany
– name: Germany
PublicationTitle Thrombosis and haemostasis
PublicationTitleAlternate Thromb Haemost
PublicationYear 2021
Publisher Georg Thieme Verlag KG
Publisher_xml – name: Georg Thieme Verlag KG
SSID ssj0016495
Score 2.6642094
SecondaryResourceType review_article
Snippet Abstract In 2018, the International Council for Standardization in Haematology (ICSH) published a consensus document providing guidance for laboratories on...
In 2018, the International Council for Standardization in Haematology (ICSH) published a consensus document providing guidance for laboratories on measuring...
SourceID proquest
pubmed
thieme
SourceType Aggregation Database
Index Database
Publisher
StartPage 1008
SubjectTerms Anticoagulation Reversal - standards
Blood Coagulation - drug effects
Blood Coagulation Tests - standards
Consensus
Drug Monitoring - standards
Evidence-Based Medicine
Factor Xa Inhibitors - adverse effects
Factor Xa Inhibitors - blood
Factor Xa Inhibitors - therapeutic use
Hemorrhage - chemically induced
Hemorrhage - prevention & control
Humans
Point-of-Care Testing - standards
Predictive Value of Tests
Reproducibility of Results
Review Article
Title 2021 Update of the International Council for Standardization in Haematology Recommendations for Laboratory Measurement of Direct Oral Anticoagulants
URI http://dx.doi.org/10.1055/a-1450-8178
https://www.ncbi.nlm.nih.gov/pubmed/33742436
https://www.proquest.com/docview/2503440914
Volume 121
WOSCitedRecordID wos000656036000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bS8MwFA46RXzxfpk3IvpabHNpskcRxx62OdDB3kLWJDhwraxV8H_4gz1pq9Phw15CIQkNfCc593MQuuYEuJKTUeCYpQEjBN5B7iToPMJpLaxpubLObFf0-3I0ag3mQTSLHnzOb3QQMR4GMhJyFa0RIFF__8Jh_OMsiFnZXCWkPpKdMF6n4S1s_k-EhI_ieWKn9hdPaW8veZodtFULjfi2QnkXrdh0D230arf4PvokwEPx8NVr7zhzGIQ6_MfUh33qeTJ5wSCi4sfaelBnYOJJijval24tLezYK6TTqa2bLeXllm5FKtnsA_fmRkX_q-rJxA8zf74Uzpdp39w-LfIDNGzfP911grrdQpDQFi8CKk3k4tAZSqPEsJCNpXFOg84iyFgzbigjMGmpIIZoocU4dhGQgKQ6ljxh9BA10iy1xwhr7VoRM0mYSMlgXgNGzIFwYIA0wlg30eU3FgrI2fsodGqzt1yBREYZ6JwRa6KjCiT1WtXdUJSCHs9o3ERXFWqqvm-5Kl3pnCutPDzKw3Oy1KpTtOkhqkL6zlCjmL3Zc7SevBeTfHZR0hmMYiRh7A96X0kQzXo
linkProvider Thieme
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Jj9MwFH6CAQEX9qWsRnCNmniJ3SNCjIpoCxJTaW6W62WmUptUTYrE_-AH8xx72MSBA7dIzlOe8j3bb38ArwXFWymoqgjcs4JTiuegCAptHhmMkd5NwtBndiYXC3V6OvmUWwp1Oa2yP1_7rS9szPSwfUy12KXup93Y5z_cjc_77SbPqRVjU1RclIWqpLoMV0QcH4GiXS7rHwGFmg8DWEoWs90pF7lU7w_iv6mZ-JAY-uXeOb71Hzm-DTez8kneJGm5A5d8cxeuzXN4_R58o3gXk-UuegFIGwgqh-Q3lyGJJex2vSGo6pLP2QuRKznJuiFTE1vADp56Eg3b7dbnoU3dQDJLItfuv5L5T-dk_FQ6esnHfeSvQf5ac3bYxCSd-7A8fnfydlrksQ2FZRPRF0y5KtRlcIxV1vGSr5QLwaDtI-nKcOEYp7jomaSOGmnkqg4VipJiplbCcvYAjpq28Y-AGBMmFXe2tEpxXDeIIw-oZDgUsbI2I3h5gZfGbRFjHabx7aHTqNkxjrZrxUfwMAGpd6l_h2ZMcqSvR_AqAacvMNJDSF4IbXSER0d4Hv_TWy_g-vRkPtOz94sPT-BGhCulCT6Fo35_8M_gqv3Sr7v980EuvwMquOuC
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Jj9MwFH6CAY24MOyUYTGCa2jiJXaPaKAaRKeMBJXmZrleoNI0qZoUaf4HP5jn2MMmDhy4RXGcPPl7sd_-AF4KiqdSUFURuGcFpxT3QREU6jwyGCO9m4ShzuxMzufq7GxymtOjuxxW2X9Z-bUvbIz0sH0Mtdik6qfd2OcV7sYbF3KbWjE2RcVFWahKqld4_ypcE8iKsZFDuah_-BRqPvRgKVkMeKdc5Gy9P17wN0kTLxJNvxw904P_S_QtuJlFUPI68cxtuOKbO7B_kp3sd-EbxROZLDbRFkDaQFBEJL8ZDklMZLerc4ICL_mYbRE5n5OsGnJsYiHYwV5Ponq7XvvcuqkbpswS47XbC3Ly00QZP5U2YPJhG-lrkL7WfN6dx1Cde7CYvv10dFzk5g2FZRPRF0y5KtRlcIxV1vGSL5ULwaAGJOnScOEYpzjomaSOGmnksg4VMpRiplbCcnYf9pq28Q-BGBMmFXe2tEpxHDcIJQ8oajhktLI2I3h-CZnGnyN6PEzj212nkQkYRw224iN4kLDUm1TFQzMmOc6vR_AiYacvYdKDY14IbXSESEeIHv3TU89g__TNVM_ezd8fwo2IVooVfAx7_Xbnn8B1-7VfddunA2d-B88v7Pw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=2021+Update+of+the+International+Council+for+Standardization+in+Haematology+Recommendations+for+Laboratory+Measurement+of+Direct+Oral+Anticoagulants&rft.jtitle=Thrombosis+and+haemostasis&rft.au=Douxfils%2C+Jonathan&rft.au=Adcock%2C+Dorothy+M.&rft.au=Bates%2C+Shannon+M.&rft.au=Favaloro%2C+Emmanuel+J.&rft.date=2021-08-01&rft.pub=Georg+Thieme+Verlag+KG&rft.issn=0340-6245&rft.eissn=2567-689X&rft.volume=121&rft.issue=8&rft.spage=1008&rft.epage=1020&rft_id=info:doi/10.1055%2Fa-1450-8178&rft.externalDBID=HTML_FULL_TEXT&rft.externalDocID=10_1055_a_1450_8178
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0340-6245&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0340-6245&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0340-6245&client=summon