Glyco-genes change expression in cancer through aberrant methylation

Most eukaryotic proteins are modified by covalent addition of glycan molecules that considerably influence their function. Aberrant glycosylation is profoundly involved in malignant transformation, tumor progression and metastasis. Some glycan structures are tumor-specific and reflect disturbed glyc...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1860; no. 8; pp. 1776 - 1785
Main Authors:	Vojta, Aleksandar, Samaržija, Ivana, Bočkor, Luka, Zoldoš, Vlatka
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.08.2016
Subjects:	biosynthesis brain Cancer data collection Databases, Genetic DNA Methylation DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Epigenesis, Genetic Epigenetics Female Gene expression Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic genes glycosylation Humans lung neoplasms lymph nodes Male mannosidases medicine melanoma metastasis Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasms - enzymology Neoplasms - genetics polysaccharides prognosis Promoter Regions, Genetic Protein glycosylation proteins transferases DNA methylation Epigenetics Protein glycosylation Gene expression Cancer
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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