EMICORON: A multi-targeting G4 ligand with a promising preclinical profile

During the last decade, guanine G-rich sequences folding into G-quadruplex (G4) structures have received a lot of attention and their biological role is now a matter of large debate. Rising amounts of experimental evidence have validated several G-rich motifs as molecular targets in cancer treatment...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1861; no. 5; pp. 1362 - 1370
Main Authors:	Porru, Manuela, Zizza, Pasquale, Franceschin, Marco, Leonetti, Carlo, Biroccio, Annamaria
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.05.2017
Subjects:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Binding Sites Cell Proliferation - drug effects Colon cancer Combination therapy DNA, Neoplasm - chemistry DNA, Neoplasm - drug effects DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Drug Design drugs G-Quadruplexes - drug effects G4 ligand guanine Guanosine - chemistry Guanosine - metabolism Humans Imides - chemical synthesis Imides - metabolism Imides - pharmacology Ligands medicinal properties Models, Molecular neoplasms Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Piperidines - chemical synthesis Piperidines - metabolism Piperidines - pharmacology signal transduction Signal Transduction - drug effects Structure-Activity Relationship Telomere - chemistry Telomere - drug effects Telomere - metabolism therapeutics Tumor Burden - drug effects G4 ligand Colon cancer TIFs CRC PDX CI TWI MTD Combination therapy G4 MTS GEMM
ISSN:	0304-4165, 1872-8006
Online Access:	Get full text
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