Cross-reactivity of two human IL-6 family cytokines OSM and LIF explored by protein-protein docking and molecular dynamics simulation

Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are two important pro-inflammatory cytokines of the interleukin-6 (IL-6) family. The two cytokines mediated signaling was recently found to be closely associated with cancer and chronic inflammation, which represent promising therapeutic target...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1865; no. 7; p. 129907
Main Authors:	Du, Qingqing, Qian, Yan, Xue, Weiwei
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.07.2021
Subjects:	bioinformatics cross reaction Cross-reactivity Cytokines Drug design Gibbs free energy humans inflammation interleukin-6 leukemia inhibitory factor molecular dynamics Molecular simulation Protein-protein interactions solvents therapeutics toxicity Molecular simulation Drug design Cytokines Cross-reactivity Protein-protein interactions
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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