Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents

To overcome the hurdles of cisplatin, majorly its toxicity and resistance, there has been extensive search for alternative anti-cancer metal-based compounds. Here, three Cu(II)-complexes, Cu(Sal-Gly)(phen), Cu(Sal-Gly)(pheamine), Cu(Sal-Gly)(phepoxy) are characterized for their interaction with DNA,...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1861; no. 2; pp. 218 - 234
Main Authors:	Acilan, Ceyda, Cevatemre, Buse, Adiguzel, Zelal, Karakas, Didem, Ulukaya, Engin, Ribeiro, Nádia, Correia, Isabel, Pessoa, João Costa
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.02.2017
Subjects:	A549 Cells agarose Animals Annexin A5 - metabolism Anti-cancer drugs Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects binding capacity Caspase 3 - metabolism Caspase 7 - metabolism caspases Cattle Cell Line, Tumor circular dichroism spectroscopy cisplatin copper Copper - chemistry Copper complexes cytotoxicity DNA - metabolism DNA damage DNA Damage - drug effects DNA Fragmentation - drug effects drug therapy fluorescence gel electrophoresis HCT116 Cells HeLa Cells Humans Interactions with DNA Mechanism of cytotoxicity of Cu-compounds membrane potential Membrane Potential, Mitochondrial - drug effects mitochondrial membrane neoplasm cells neoplasms Phenanthroline phenotype quantitative polymerase chain reaction reactive oxygen species Reactive Oxygen Species - metabolism reverse transcriptase polymerase chain reaction Schiff base compounds staining supercoiled DNA Tumor Suppressor Protein p53 - metabolism Up-Regulation - drug effects Mechanism of cytotoxicity of Cu-compounds Schiff base compounds Phenanthroline Interactions with DNA Anti-cancer drugs Copper complexes
ISSN:	0304-4165, 1872-8006
Online Access:	Get full text
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