Cell population heterogeneity and evolution towards drug resistance in cancer: Biological and mathematical assessment, theoretical treatment optimisation

Drug-induced drug resistance in cancer has been attributed to diverse biological mechanisms at the individual cell or cell population scale, relying on stochastically or epigenetically varying expression of phenotypes at the single cell level, and on the adaptability of tumours at the cell populatio...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1860; no. 11; pp. 2627 - 2645
Main Authors:	Chisholm, Rebecca H., Lorenzi, Tommaso, Clairambault, Jean
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.11.2016
Subjects:	Cancer cell populations Cancer therapeutics cytotoxicity Drug resistance Drug Resistance, Neoplasm - drug effects drugs epigenetics Evolution Heterogeneity human diseases Humans Immunotherapy - methods mathematical models Models, Biological Models, Theoretical neoplasm cells neoplasms Neoplasms - drug therapy Neoplasms - pathology Optimal control Phenotype population dynamics therapeutics Heterogeneity Evolution Cancer cell populations Cancer therapeutics Drug resistance Optimal control
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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