Cell population heterogeneity and evolution towards drug resistance in cancer: Biological and mathematical assessment, theoretical treatment optimisation

Drug-induced drug resistance in cancer has been attributed to diverse biological mechanisms at the individual cell or cell population scale, relying on stochastically or epigenetically varying expression of phenotypes at the single cell level, and on the adaptability of tumours at the cell populatio...

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Vydáno v:	Biochimica et biophysica acta Ročník 1860; číslo 11; s. 2627 - 2645
Hlavní autoři:	Chisholm, Rebecca H., Lorenzi, Tommaso, Clairambault, Jean
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 01.11.2016
Témata:	Cancer cell populations Cancer therapeutics cytotoxicity Drug resistance Drug Resistance, Neoplasm - drug effects drugs epigenetics Evolution Heterogeneity human diseases Humans Immunotherapy - methods mathematical models Models, Biological Models, Theoretical neoplasm cells neoplasms Neoplasms - drug therapy Neoplasms - pathology Optimal control Phenotype population dynamics therapeutics Heterogeneity Evolution Cancer cell populations Cancer therapeutics Drug resistance Optimal control
ISSN:	0304-4165, 0006-3002, 1872-8006
On-line přístup:	Získat plný text
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