Distribution of metastatic sites in patients with prostate cancer: A population-based analysis

BACKGROUND There is few data on what constitutes the distribution of metastatic sites in prostate cancer (PCa). The aim of our study was to systematically describe the most common sites of metastases in a contemporary cohort of PCa patients. METHODS Patients with metastatic PCa were ed from the Nati...

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Vydané v:The Prostate Ročník 74; číslo 2; s. 210 - 216
Hlavní autori: Gandaglia, Giorgio, Abdollah, Firas, Schiffmann, Jonas, Trudeau, Vincent, Shariat, Shahrokh F., Kim, Simon P., Perrotte, Paul, Montorsi, Francesco, Briganti, Alberto, Trinh, Quoc-Dien, Karakiewicz, Pierre I., Sun, Maxine
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Blackwell Publishing Ltd 01.02.2014
Wiley Subscription Services, Inc
Predmet:
Adrenal Gland Neoplasms - epidemiology
Adrenal Gland Neoplasms - secondary
Aged
Aged, 80 and over
bone metastases
Bone Neoplasms - epidemiology
Bone Neoplasms - secondary
Brain Neoplasms - epidemiology
Brain Neoplasms - secondary
Databases, Factual
Humans
Kidney Neoplasms - epidemiology
Kidney Neoplasms - secondary
Liver Neoplasms - epidemiology
Liver Neoplasms - secondary
Lung Neoplasms - epidemiology
Lung Neoplasms - secondary
Lymphatic Metastasis
Male
Medical research
metastatic disease
Middle Aged
Prevalence
Prostate cancer
Prostatic Neoplasms - pathology
Retrospective Studies
sites of metastases
Thoracic Neoplasms - epidemiology
Thoracic Neoplasms - secondary
United States
United States
bone metastases
prostate cancer
metastatic disease
sites of metastases
ISSN:0270-4137, 1097-0045, 1097-0045
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Shrnutí:BACKGROUND There is few data on what constitutes the distribution of metastatic sites in prostate cancer (PCa). The aim of our study was to systematically describe the most common sites of metastases in a contemporary cohort of PCa patients. METHODS Patients with metastatic PCa were ed from the Nationwide Inpatient Sample (1998–2010). Most common metastatic sites within the entire population were described. Stratification was performed according to the presence of single or multiple (≥2 sites) metastases. Additionally, we evaluated the distribution of metastatic sites amongst patients with and without bone metastases. RESULTS Overall, 74,826 patients with metastatic PCa were identified. The most common metastatic sites were bone (84%), distant lymph nodes (10.6%), liver (10.2%), and thorax (9.1%). Overall, 18.4% of patients had multiple metastatic sites involved. When stratifying patients according to the site of metastases, only 19.4% of men with bone metastases had multiple sites involved. Conversely, among patients with lymph nodes, liver, thorax, brain, digestive system, retroperitoneum, and kidney and adrenal gland metastases the proportion of men with multiple sites involved was 43.4%, 76.0%, 76.7%, 73.0%, 52.2%, 60.9%, and 76.4%, respectively. When focusing exclusively on patients with bone metastases, the most common sites of secondary metastases were liver (39.1%), thorax (35.2%), distant lymph nodes (24.6%), and brain (12.4%). CONCLUSIONS Although the majority of patients with metastatic PCa experience bone location, the proportion of patients with atypical metastases is not negligible. These findings might be helpful when planning diagnostic imaging procedures in patients with advanced PCa. Prostate 74:210–216, 2014. © 2013 Wiley Periodicals, Inc.
Bibliografia:University of Montreal Health Centre (CHUM) Foundation.
ArticleID:PROS22742
Fonds de la Recherche en Santé du Québec
Department of Surgery, University of Montreal
istex:925C80F7C68986A75EB6332E315777C6114D2CB9
University of Montreal Health Centre Urology Specialists
ark:/67375/WNG-ZTL0W8F3-P
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0270-4137
1097-0045
1097-0045
DOI:10.1002/pros.22742