Statistically Consistent k-mer Methods for Phylogenetic Tree Reconstruction

Frequencies of k-mers in sequences are sometimes used as a basis for inferring phylogenetic trees without first obtaining a multiple sequence alignment. We show that a standard approach of using the squared Euclidean distance between k-mer vectors to approximate a tree metric can be statistically in...

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Bibliographic Details

Published in:	Journal of computational biology Vol. 24; no. 2; p. 153
Main Authors:	Allman, Elizabeth S, Rhodes, John A, Sullivant, Seth
Format:	Journal Article
Language:	English
Published:	United States 01.02.2017
Subjects:	Algorithms Base Sequence Computer Simulation Evolution, Molecular Models, Genetic Phylogeny Sequence Alignment Sequence Analysis, DNA k-mer phylogenetic trees alignment-free methods
ISSN:	1557-8666, 1557-8666
Online Access:	Get more information
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